DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pcl and PHF19

DIOPT Version :10

Sequence 1:NP_476672.1 Gene:Pcl / 37069 FlyBaseID:FBgn0003044 Length:1043 Species:Drosophila melanogaster
Sequence 2:XP_005251963.2 Gene:PHF19 / 26147 HGNCID:24566 Length:639 Species:Homo sapiens


Alignment Length:724 Identity:187/724 - (25%)
Similarity:271/724 - (37%) Gaps:228/724 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   353 LQEDVFIKC--NDGRFYLGTI--IDQTSDQYLIRFDDQSEQWCEPDKLRKLGGGSSITAGGGGAS 413
            |.|..::.|  .||.:|||.|  :..:....|:.|:|.|:.|.....::.        ||..|..
Human    99 LTEGQYVLCRWTDGLYYLGKIKRVSSSKQSCLVTFEDNSKYWVLWKDIQH--------AGVPGEE 155

  Fly   414 TTESTNTSPSGPMCVAC--KRSDIEDVVEICERCGRGYHRGCTVEIVTGSG------IWSCKRCA 470
                       |.|..|  |.|...:.:.||.:||.|||:.|.:.| .||.      .|.|:||.
Human   156 -----------PKCNICLGKTSGPLNEILICGKCGLGYHQQCHIPI-AGSADQPLLTPWFCRRCI 208

  Fly   471 KPMKMQQPVSHKITKPAGICRQ-------LPYHADKLSWDEKHRVNEEQIYCYCGKPGKFDHNML 528
            ..:.:::..:   .|...|.|.       |.|..::|.||..||.|::|.|||||.||::...||
Human   209 FALAVRKGGA---LKKGAIARTLQAVKMVLSYQPEELEWDSPHRTNQQQCYCYCGGPGEWYLRML 270

  Fly   529 QCCKCRNWFHTQCMQNFKKKLLRGDMFFVFCCTVCNNGIEFVRRMQIEWVDVLHIALYNLRKHQH 593
            ||.:||.|||..|.|...:.::.||.|::|.|:|||.|.|::.|:.:.||||:|:|||||.....
Human   271 QCYRCRQWFHEACTQCLNEPMMFGDRFYLFFCSVCNQGPEYIERLPLRWVDVVHLALYNLGVQSK 335

  Fly   594 QKYHHLLNDIWPFILEQRHQLPICE--KWRTLPETALMERLKQTLKDYSDRFVCGREFKRAPAFY 656
            :||.. ..:|..|:   .|...:.:  |..:.|.|.....|...|..|..||:||:|.|:....:
Human   336 KKYFD-FEEILAFV---NHHWELLQLGKLTSTPVTDRGPHLLNALNSYKSRFLCGKEIKKKKCIF 396

  Fly   657 ALRHSGPPHIPKVFLEPHEELSDELLEKRFKLMLMPEEPDEGANELPKRVPKDVYEFNTDEDDPV 721
            .||...||:.|           .:||..:   .|:|.| :..::||.||                
Human   397 RLRIRVPPNPP-----------GKLLPDK---GLLPNE-NSASSELRKR---------------- 430

  Fly   722 ETSEDEIPIKQIIEKAKKQAAQKADKHDELPLKPDLADDNANDGDPGKLPAPIPPLLDANSSRKR 786
                         .|:|                            ||.||............|||
Human   431 -------------GKSK----------------------------PGLLPHEFQQQKRRVYRRKR 454

  Fly   787 KAFRLSKRYDN-------SRNH-----CDLSSDE----NSSSSRGT--SSLDLIIPPPVNFLGRN 833
            ..|.|.....:       |.||     .|.:.||    .|:||..|  |.:|             
Human   455 SKFLLEDAIPSSDFTSAWSTNHHLASIFDFTLDEIQSLKSASSGQTFFSDVD------------- 506

  Fly   834 NPFLMATPKKASQGRSISVGTGVGVNGIINSIFKLKGTSKEQPRMVRTIKRRLSAKDITIGPNQE 898
                 :|...::.|   |..|.:               |.:....|.:.||:|:||         
Human   507 -----STDAASTSG---SASTSL---------------SYDSRWTVGSRKRKLAAK--------- 539

  Fly   899 VRRRRTRRLTTAIEVISTTTINPIPSHYLPIYAK----DLQPPAPPMGKPTHGRLLRQRPQKQSP 959
                                      .|:|:.||    :|.... |......|..:.:||.:   
Human   540 --------------------------AYMPLRAKRWAAELDGRC-PSDSSAEGASVPERPDE--- 574

  Fly   960 SQSRRNSTSSTATSSSSNGIGAPGHSMLDLKQSVNKYFGGAMNRIDAGEPFAIRAKRRMGNGQVQ 1024
                      ...|.:...|.....|:..||.|:..|||.| .|:..||.:.:.|:|....|:||
Human   575 ----------GIDSHTFESISEDDSSLSHLKSSITNYFGAA-GRLACGEKYQVLARRVTPEGKVQ 628

  Fly  1025 YLVEWGGDT 1033
            |||||.|.|
Human   629 YLVEWEGTT 637

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PclNP_476672.1 PRK12323 <13..107 CDD:481241
Tudor_dPCL-like 350..401 CDD:410523 14/51 (27%)
PHD_SF 426..469 CDD:473978 17/50 (34%)
PHD2_MTF2_PHF19_like 514..565 CDD:276978 25/50 (50%)
Mtf2_C 985..1033 CDD:464077 22/47 (47%)
PHF19XP_005251963.2 Tudor_PHF19 98..154 CDD:410522 16/62 (26%)
PHD1_PHF19 157..209 CDD:277054 19/52 (37%)
PHD2_PHF19 256..307 CDD:277056 25/50 (50%)
Mtf2_C 590..637 CDD:464077 22/47 (47%)
Blue background indicates that the domain is not in the aligned region.

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