Protein Alignment Pcl and LOC1270508

DIOPT Version :10

• Sequence 1: NP_476672.1
• Gene: Pcl / 37069
• FlyBaseID: FBgn0003044
• Length: 1043
• Species: Drosophila melanogaster
• Sequence 2: XP_061518984.1
• Gene: LOC1270508 / 1270508
• VectorBaseID: AGAMI1_007067
• Length: 1112
• Species: Anopheles gambiae
• Alignment Length: 1206
• Identity: 258/1206 - (21%)
• Similarity: 385/1206 - (31%)
• Gaps: 453/1206 - (37%)

  Fly   150 SGGGQTAGQINLL----------------AASGTGKQLQPPPLVPVTNSTSPPS-----TVVLDR 193
            :|||.||.|.|..                :..|.|........|.|..|.||.|     .::.||
Mosquito    31 TGGGATANQPNASRSPGEERLARNGESGGSVGGAGGSGGGGGGVGVGASGSPGSGESRHIIIHDR 95

  Fly   194 ------------------INICIN--NHYTETPTSLSSSLTTAQQPSPIIPAIQHK-----AILP 233
                              :.|.||  ..|...|....|:      ...:...::||     .:|.
Mosquito    96 PRAAGGGGSITILTPTNNLKISINKKRRYPGRPHEYQSA------KRALTHNLRHKLGELDKLLK 154

  Fly   234 LIDSSTADSSSCSSSSVSSSSYSGTATTSAAVVIVDEPDSTTTTPQTPPTTPEAMSSPGKSSPSP 298
            ..|:...|...........              ::.|.|.....|        |.:..||.||:
Mosquito   155 ACDNEDEDEDEDDDEDEDD--------------VMQEGDVQVRAP--------AANGTGKRSPA- 196

  Fly   299 PLLATQSLLKGVNSMKPSFKTVEAAPPTPPTPPSPPPPP------------PAPPVAAPSPAVT- 350
                                   ||..:|..||||.|||            |.|.|....|:.|
Mosquito   197 -----------------------AANTSPVVPPSPSPPPAFSLLARKDAVQPLPSVKPCHPSTTA 238

  Fly   351 ----YALQ----------------------------------EDVFIK-CNDGRFYLGTIID-QT 375
                .|.|                                  |||.:: .|:.::||||:|: :.
Mosquito   239 EKVEQACQIVSATSTSNGADSGDGSSDAREEESVEIDHLRPCEDVLVRISNNDQYYLGTVIEFEP 303

  Fly   376 SDQYLIRFDDQSEQWCEPDKLRKLGGGSSITAGGGGASTTESTNTSPSGPMCVACKRS------- 433
            ....|:||:||:....|..::.::        .|.|.....:.|.....|    |.||
Mosquito   304 KRSCLVRFEDQTTVRVELSRITRM--------AGNGVRNPHTANPRQPSP----CPRSVDQAVQV 356

  Fly   434 -----------DIEDVVEICERCGR-----------------GYHRGCTVEIVTGSGIWSCKRCA 470
                       ..::.||..||..|                 .|......|....:|..|.:|..
Mosquito   357 DREERHDKAEQQRQEHVEQVERTKREKQLEHVNQKPQEEFLEEYLEQEEPERPAANGKCSGERDQ 421

  Fly   471 KPMKM----------------------------QQPVSHKITK-----------PAGICRQLPYH 496
            :.|.:                            |.|.:....|           |.....||||.
Mosquito   422 QEMLVDHVEEKEPEEECVSLTNDNAPNSLSAASQAPSAQPAPKFRSIVIPDEFSPLTSASQLPYS 486

  Fly   497 ADKLSWDEKHRVNEEQIYCYCGKPGKFDHNMLQCCKCRNWFHTQCMQNFKKKLLRGDMFFVFCCT 561
            ...|.||.:||||.|:.|||||..|::...|:||.:|..|||.:|:::.:..:|.||.|::|.|:
Mosquito   487 LHALHWDSEHRVNAERHYCYCGADGEWTREMIQCRRCEQWFHGRCVRSLQFPILLGDTFYLFICS 551

  Fly   562 VCNNGIEFVRRMQIEWVDVLHIALYNLRKHQHQKYHHLLNDIWPFILEQRHQLPICEKWRTLPET 626
            :||:|.|||||.::..|:::|:|||||......:.:.|...|.|:|.:....|       .||.:
Mosquito   552 ICNHGHEFVRRFELGTVNLVHLALYNLIMRNGCRLYDLRLAIVPYIEDNLRAL-------QLPSS 609

  Fly   627 AL-------MERLKQTLKDYSDRFVCGREFKRAPAFYALRHSGPP-----HIPKVFLEPHEELSD 679
            ||       ::.|:.||:..:|||:.|||..:....:.||.:.||     .||   |...|.:::
Mosquito   610 ALKLTTSERIDLLQLTLRYNTDRFLNGREVSQPANLWTLRKALPPPMKATTIP---LGAEETVTE 671

  Fly   680 ELLEKRFKLMLMPEEPDEGANELPKRVPKDVYEFN------TDE--------DDPVETSEDEIPI 730
            .||.     ||.|      ..::|..:|:..:|.|      |.|        :.|...::..|..
Mosquito   672 HLLR-----MLPP------CLQVPCFLPRTNHEKNFFMDAATRERMLGLNYAERPTSFADPRINF 725

  Fly   731 KQIIEKAKKQAAQKADKHDELPLKPDLADDNANDGDPGKLPAPIPPLLDANSSRKRKAFRLSKRY 795
            ..:|       |..|..|  ....||:.|        ||....:.....|.:...:.......|.
Mosquito   726 ADLI-------APPAVLH--ASASPDVTD--------GKSTGTVASTAVAATGASQPLSTAGARV 773

  Fly   796 DNSRNHCDLSSDENSSSSRGT---------------------------------SSLDLIIPPPV 827
            .      |.|...|||.:.||                                 ..|:.:.||..
Mosquito   774 P------DASLASNSSPTSGTVPFNATNGARLIGARKRKQRGIRFIAPVLLPMRDRLESLFPPRA 832

  Fly   828 NFLGRNNPFLMATP------------KKAS----------QG----RSISVG------TGVGVNG 860
            ||.|.||||....|            :|.|          ||    |.::.|      .|.....
Mosquito   833 NFDGANNPFYRLEPPVPYGLGRIRGGRKGSVKRRTVDGHRQGPAMKRQLTSGEFLHKRAGAAPAA 897

  Fly   861 IINSIFKLKGTSKEQPRM----------VRTIKRRLSAKDITIGPN--QEVRRRRTRRLTT---- 909
            ..:.:.:...|..:..::          |:.::|..||.. |.||:  ..|..||.|...|
Mosquito   898 AASHLSRRASTGGQLQKIDENSVLSELSVQNVQRHNSAHS-TSGPSSGSAVSGRRARSSHTYSTS 961

  Fly   910 --------AI-----EVISTTTINPIPSHYLPIYAKDLQPPAPPMGKPTHGRLLRQRPQKQSPS- 960
                    |:     .|.|.|:.           .:|.:|.|  .|:.:.|||:....:..|.:
Mosquito   962 STSSEQVGAVGGGSGSVASDTSA-----------TEDHKPMA--SGRRSSGRLVALASKNYSDTK 1013

  Fly   961 --QSRRNSTS---------STATSSSSNGIGAPGHSMLDLKQSVNKYFGGAMN------------ 1002
              :.||||.:         |..|:...|    ||.:..........|:....|
Mosquito  1014 RHKRRRNSDTAILAGELNVSNGTAEEQN----PGRTRAAGGGGSGGYYSSTSNSSCMVSGVYWDP 1074

  Fly  1003 ---------RIDAGEP-FAIRAKRRMGNGQVQYLVE 1028
                     |.....| ||:..||.:.||:.:.|.|
Mosquito  1075 TAVREPVQTRNRTSRPMFAVVGKRVLPNGKQELLWE 1110

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pcl	NP_476672.1	PRK12323	<13..107	CDD:481241
		Tudor_dPCL-like	350..401	CDD:410523	18/91 (20%)
		PHD_SF	426..469	CDD:473978	12/77 (16%)
		PHD2_MTF2_PHF19_like	514..565	CDD:276978	21/50 (42%)
		Mtf2_C	985..1033	CDD:464077	12/66 (18%)
LOC1270508	XP_061518984.1	None