DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pcl and phf1

DIOPT Version :10

Sequence 1:NP_476672.1 Gene:Pcl / 37069 FlyBaseID:FBgn0003044 Length:1043 Species:Drosophila melanogaster
Sequence 2:XP_012824941.1 Gene:phf1 / 100038119 XenbaseID:XB-GENE-491884 Length:552 Species:Xenopus tropicalis


Alignment Length:765 Identity:167/765 - (21%)
Similarity:247/765 - (32%) Gaps:282/765 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   327 PPTPPSPPPPPPAPPVAAPSPAVTYAL--------------QEDVFIKCNDGRFYLGTI--IDQT 375
            |.|.||...|        .||.||.||              .:||..:..||..|||.|  :|..
 Frog     6 PSTRPSRTTP--------ASPRVTPALVKRPRFQTLARFWEGQDVLARWTDGLLYLGIIKKVDSA 62

  Fly   376 SDQYLIRFDDQSEQWCEPDKLRKLGGGSSITAGGGGASTTESTNTSPSGP----MCVACKRSDI- 435
            .:..|:||:|.|:                       .|........|:.|    :|..|..... 
 Frog    63 QETCLVRFEDNSQ-----------------------FSVLWKDIFPPAVPGKEQLCCVCNSQTCT 104

  Fly   436 -EDVVEICERCGRGYHRGCTVEIV------TGSGIWSCKRCAKPMKMQQPVSHKITKPAGICRQ- 492
             ::.:..|.:|...||:.|.|..|      .||. |.|::|         |....||..|..:: 
 Frog   105 PDNKLVHCGKCKHAYHQECHVPSVPCDTDCPGSS-WMCRQC---------VFAVATKRGGALKKG 159

  Fly   493 ------------LPYHADKLSWDEKHRVNEEQIYCYCGKPG--------KFDHNMLQCCKCRNWF 537
                        |||....|.||:.|..|::|.|||||.||        :::..|||||:|..||
 Frog   160 PYARAMLHMKLSLPYQLKSLEWDQLHLTNKQQCYCYCGGPGEHTYMCPLRWNMKMLQCCRCLQWF 224

  Fly   538 HTQCMQNFKKKLLRGDMFFVFCCTVCNNGIEFVRRMQIEWVDVLHIALYNLRKHQHQKYHHLLND 602
            |..|.|...|.||.||.|:||.|:||..|.|...|:.:.||||.|:.||:|.....:||.....:
 Frog   225 HEACTQCLSKPLLYGDRFYVFECSVCTRGPENAWRLPLAWVDVSHLVLYHLSICCKKKYFDFERE 289

  Fly   603 IWPFILEQRHQLPICEKWRTLPETALMER---LKQTLKDYSDRFVCGREFKRAPAFYALRHSGPP 664
            |..|:.|....|.:.|    |.:|...||   |...|....|||:.|:|.|:....:.|:...||
 Frog   290 ILSFVNENWDSLLLGE----LTDTPRSERYSHLLHALTAQKDRFISGKEIKKKKCLFGLQTRVPP 350

  Fly   665 HIPKVFLEPHEELSDELLEKRFKLMLMPEEPDEGANELPKRVPKDVYEFNTDEDDPVETSEDEIP 729
            ..|:                                             :|:.....:.|:|...
 Frog   351 PAPQ---------------------------------------------STESQLRQQESKDRTS 370

  Fly   730 IKQIIEKAKKQAAQKADKHDELPLKPDLADDNANDGDPGKLPAPIPPLLDANSSRKRKAFRLSKR 794
            ...:.....:....:...|.:....                       ::..:.|:|:....:..
 Frog   371 TPCVSSLVGRMGITRRPTHRKRTQS-----------------------IEKQTGRERQKLCKALT 412

  Fly   795 YDNSRNHCDLSSDENSSSSRGTSSLDLIIPPPVNFLG------RNNPFLMATPKKASQGRSISVG 853
            .|..:|  ..||::.....||::         .||..      :|.|..|......|...|.||.
 Frog   413 QDVVQN--PFSSNQEYQGYRGSA---------YNFRRTGARCLQNPPIRMFASFHPSANTSGSVA 466

  Fly   854 TGVGVNGIINSIFKLKGTSKEQPRMVRTIKRRLSAKDITIGPNQEVRRRRTRRLTTAIEVISTTT 918
            ..:..:|:.:.:        :.|.:              :|...|                   |
 Frog   467 ASLQSSGMSSEV--------QDPPL--------------LGEMME-------------------T 490

  Fly   919 INPIPSHYLPIYAKDLQPPAPPMGKPTHGRLLRQRPQKQSPSQSRRNSTSSTATSSSSNGIGA-- 981
            ..|.|:   .:.:..:.|..|                            ||:.:|.....:|:  
 Frog   491 AGPAPA---SLSSPQVTPSLP----------------------------SSSVSSEGCAWLGSTE 524

  Fly   982 PGHSMLDLKQSVNKYFGGAMNRIDAGEPFAIRAKRRMGNGQVQYLVEWGG 1031
            ||..:|                          |:|....|.|||||||||
 Frog   525 PGMRVL--------------------------ARRVTAQGAVQYLVEWGG 548

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PclNP_476672.1 PRK12323 <13..107 CDD:481241
Tudor_dPCL-like 350..401 CDD:410523 17/66 (26%)
PHD_SF 426..469 CDD:473978 13/50 (26%)
PHD2_MTF2_PHF19_like 514..565 CDD:276978 29/58 (50%)
Mtf2_C 985..1033 CDD:464077 13/47 (28%)
phf1XP_012824941.1 Tudor_PHF1 35..88 CDD:410520 16/75 (21%)
PHD1_PHF1 94..144 CDD:276975 13/50 (26%)
PHD_SF 193..252 CDD:473978 29/58 (50%)
Mtf2_C <528..549 CDD:464077 13/47 (28%)
Blue background indicates that the domain is not in the aligned region.

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