Protein Alignment POSH and Nost

DIOPT Version :10

• Sequence 1: NP_523776.1
• Gene: POSH / 36990
• FlyBaseID: FBgn0040294
• Length: 838
• Species: Drosophila melanogaster
• Sequence 2: NP_001285029.1
• Gene: Nost / 8673992
• FlyBaseID: FBgn0259734
• Length: 1330
• Species: Drosophila melanogaster
• Alignment Length: 1038
• Identity: 209/1038 - (20%)
• Similarity: 334/1038 - (32%)
• Gaps: 338/1038 - (32%)

  Fly    41 VASQHKLRCPECRILVSCKIDELPPNVLLMRILEGMKQ-NAAAGKGEEKGEETETQPERA----- 99
            ||....:..| .::.:...:.|||.       |.|..: :.||...:|.....:...||:
  Fly   390 VALDMNVTAP-AKLGLDLNLPELPE-------LYGASELSLAASDNKENLPAVKPSAERSPIPNG 446

  Fly   100 ---KPQPPAESVAPPDNQLLQLQSHQQSHQPARHKQRRFL-LPHAYALFDFASGEATDLKFKKGD 160
               ..||..:|:   |:..|..:||  |:|.::...|:.| ...:...:||             |
  Fly   447 GFMAQQPHFKSL---DSFHLNTRSH--SNQSSQQSSRQSLACSSSNGEYDF-------------D 493

  Fly   161 LILIKHRIDN--NWFVGQANGQEGTFPINYVK-VSVPLPMPQCIAMYDFKMGPNDEE-GCLEFKK 221
            |..:.::..|  |.||.....||.|..||..: ....:.:..| |..| ::.|::.. ..|:.|.
  Fly   494 LKSVSYQSLNAQNLFVSIDELQELTRQINETEDFGKEIDLEYC-AHRD-QLRPSERRITLLKNKN 556

  Fly   222 STVI------QVMRRVDH---NWAEGRIGQTIGIFPIAFVELNAAAKKLLDSGLHTHPFCHPPKQ 277
            .|:|      :.:|:..|   :|. |..|..|.    ..|......|:|..|..:.:.......:
  Fly   557 QTLINFNHNKEKLRKGWHGMKHWL-GEEGSKIK----EAVRQQTPLKRLAQSRSNLNQSTADASR 616

  Fly   278 QGQRALPPVPVIDPTVVTESSSGSSNSTPGSSNSSSTSSSNNCSPNHQISLPNTPQHVVASGSAS 342
            |...     |......||||....:..|...|:.|..:|..:.||:                  :
  Fly   617 QSMS-----PERTQRDVTESCEDVTERTEMESSMSHRNSEEDLSPH------------------A 658

  Fly   343 VRFRDKGA---KEKRHSLNALLGG--GAPLSLLQTNRHSAEIL------SLPHELSRL--EVSSS 394
            .||:|:|.   :|.|..:..  ||  ...|..:...|..:|::      .|.::|::.  |:..|
  Fly   659 KRFKDEGQNGFEELRRYVKQ--GGDFSKELIFVLQERADSELIYSKSLSKLANKLNKAGREIPGS 721

  Fly   395 TA----------------------------LKP----------------TSAPQTSRVL------ 409
            .|                            :||                ::..:.:|||
  Fly   722 VADAWRGVATEMESRSDIHRQLAASLTDELVKPLKIVVEGHHKARKAVESNVDKAARVLGEWRAS 786

  Fly   410 ---------------------KTTVQQQMQPNLPWGYLALFPYKP-RQTDELELK---KGCVYIV 449
                                 ...|:.|..|:     :||....| :|..|.|||   |.||.:.
  Fly   787 EAKAKKASHTAARENEKLQDAMLDVRIQKSPS-----IALLHQGPNKQAAEKELKSAEKDCVKLD 846

  Fly   450 TERCVDGWFKGKNWLDITGVFPGNYLTPLRARDQQQLMHQWKYVPQNADAQMAQVQQHPVAPDVR 514
            .:|     .|.:..:....|   .|.| |..|.::..: .|:.......||:...:|.      |
  Fly   847 NKR-----KKAEEAVKRADV---EYYT-LCVRSERARV-DWEMAVLRGSAQLQSSEQQ------R 895

  Fly   515 LNNM----------LSMQPPDLPPRQQQATATTTSCSVWSKPVEAL--FSRKSE-PK----PETA 562
            |.||          :|...|.|.....:......:|:| :|.::.:  ..|.|| |.    |:..
  Fly   896 LGNMHNFAQQYARLISDMNPILGGLSTRLQPQLDACNV-AKDMQVVRHIRRNSEGPSEQLLPDFY 959

  Fly   563 TASTTSS--------------------------SSSGAVGLMRRLTHMKTRS--------KSPGA 593
            ...||.:                          |..|..||.:.|.|.:.::        :|...
  Fly   960 CEHTTLAMNRERRKHALIKLLQLVKTDLERERRSRDGLRGLSQSLNHQEHQNITDKLYHIRSMLT 1024

  Fly   594 SLQQVPKEAISTNVEFTTNPSAKLHP----VHV---RSGSCPSQLQHSQPLNETPAAKTAAQQQQ 651
            .|:....:..|..:|....|.| .||    :|:   |:|...|.|:....|.....::| .|...
  Fly  1025 YLEGARLKLHSALLELDHKPRA-THPLAQHIHITRDRTGLQQSILKVPNWLKNNDKSQT-QQSTS 1087

  Fly   652 FLPKQLPSASTN--------------SVSYGSQRVKGSKERPHLICARQSLDAATF-RSMYN--- 698
            .|...:...:||              |.|:.:....||       |...|.....| ||..|
  Fly  1088 MLAHDITDITTNHEDELPDENCSHLHSSSHSNNNSNGS-------CTDVSSVVKPFNRSKSNIET 1145

  Fly   699 NAASPPP--PTTSVAPAVYAGGQQQV-IPGGGAQSQLHANMIIAPSHRKSHSLDASHVLSPSSN- 759
            |..|.|.  .||:.|.||....:... :..|...:|.|.:      |..:|..|.......|:.
  Fly  1146 NFTSQPKIISTTNAAIAVSVKSKTLANLQDGHHNNQQHHH------HHHNHHSDRGQADGGSNQQ 1204

  Fly   760 -----------------------------------MITEAAIKASATTKSPYCTRE--------- 780
                                               ::....|.....|:..|...:
  Fly  1205 DSDFDEFSSQDEDDEPQQPQQQPQPLQSQQQQQQPLLQNPTINGQVQTQHFYQNAQELQKGQKNG 1269

  Fly   781 -----SRFRCIVPYPPNSDIELELHLGDIIYVQRKQKNGWYKGTHARTHKTGLFPASFVEPDC 838
                 .|.:.:..|.|....||||..||||.|..||.:||:.|. .|.| .|:|||::|| :|
  Fly  1270 SVPILGRCKALYSYTPKLYDELELSPGDIIEVHAKQDDGWWLGA-LRNH-IGIFPATYVE-EC 1329

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
POSH	NP_523776.1	RAD18	6..>113	CDD:227719	16/80 (20%)
		RING-HC_SH3RF3	8..53	CDD:438408	3/11 (27%)
		SH3	139..191	CDD:473055	13/54 (24%)
		SH3_SH3RF_2	199..251	CDD:212721	14/61 (23%)
		SH3_SH3RF_3	424..477	CDD:212717	15/56 (27%)
		SH3_SH3RF_C	782..836	CDD:212719	24/53 (45%)
Nost	NP_001285029.1	F-BAR_NOSTRIN	663..908	CDD:153342	48/267 (18%)
		SH3_Nostrin	1276..1328	CDD:212757	25/54 (46%)