Protein Alignment POSH and SH3RF1

DIOPT Version :10

• Sequence 1: NP_523776.1
• Gene: POSH / 36990
• FlyBaseID: FBgn0040294
• Length: 838
• Species: Drosophila melanogaster
• Sequence 2: NP_065921.2
• Gene: SH3RF1 / 57630
• HGNCID: 17650
• Length: 888
• Species: Homo sapiens
• Alignment Length: 1014
• Identity: 294/1014 - (28%)
• Similarity: 428/1014 - (42%)
• Gaps: 307/1014 - (30%)

  Fly     1 MDEHTLNDLLECSVCLERLDTTSKVLPCQHTFCRKCLQDIVASQHKLRCPECRILVSCKIDELPP 65
            |||..|.|||||.|||||||.::||||||||||::||..||.|:::|||||||.||...::|||.
Human     1 MDESALLDLLECPVCLERLDASAKVLPCQHTFCKRCLLGIVGSRNELRCPECRTLVGSGVEELPS 65

  Fly    66 NVLLMRILEGMKQNA-AAGKGEEKG-----------------EETETQPERAKPQPPAESVAPPD 112
            |:||:|:|:|:||.. ..|.|...|                 ...:.|..:...||..:|.:||.
Human    66 NILLVRLLDGIKQRPWKPGPGGGSGTNCTNALRSQSSTVANCSSKDLQSSQGGQQPRVQSWSPPV 130

  Fly   113 NQLLQLQSHQQSHQPARHKQRRFLLPHAYALFDFASGEATDLKFKKGDLILIKHRIDNNWFVGQA 177
            ..:.|                   ||.|.||:::...|..||||.|||:|:::.::|.||:.|:.
Human   131 RGIPQ-------------------LPCAKALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEV 176

  Fly   178 NGQEGTFPINYVKVSVPLPM--PQCIAMYDFKMGPND-EEGCLEFKKSTVIQVMRRVDHNWAEGR 239
            ||..|.||.|:|::..|||.  |||.|:|||::...: ::.||.|.|..|:.|:||||.|||||.
Human   177 NGIHGFFPTNFVQIIKPLPQPPPQCKALYDFEVKDKEADKDCLPFAKDDVLTVIRRVDENWAEGM 241

  Fly   240 IGQTIGIFPIAFVELNAAAKKLLDSGLHTHPFCHPPKQQGQRALPPVPVIDPTVVTESSSGSSNS 304
            :...||||||::||.|:|||:|::..                 .||||.:|
Human   242 LADKIGIFPISYVEFNSAAKQLIEWD-----------------KPPVPGVD-------------- 275

  Fly   305 TPGSSNSSSTSSSNNCSPNHQISLPNTPQHVVASGSASVRFRDKGAKEKRHSLNALLGGGAPLSL 369
               :...||.::.::.:|.|..:..||                    :||||..:|...... |.
Human   276 ---AGECSSAAAQSSTAPKHSDTKKNT--------------------KKRHSFTSLTMANKS-SQ 316

  Fly   370 LQTNRHSAEILSLP--------------HELSRLEVS-------SSTAL---KPTSAPQT----- 405
            ...||||.|| |.|              .|||.|..|       |:|.|   .|.|:|.|
Human   317 ASQNRHSMEI-SPPVLISSSNPTAAARISELSGLSCSAPSQVHISTTGLIVTPPPSSPVTTGPSF 380

  Fly   406 --------------------------SRVLKTT---------------------------VQQQM 417
                                      :.||.:|                           ::.|.
Human   381 TFPSDVPYQAALGTLNPPLPPPPLLAATVLASTPPGATAAAAAAGMGPRPMAGSTDQIAHLRPQT 445

  Fly   418 QPNLPWGYLALFPYKPRQTDELELKKGCVYIVTERCVDGWFKGKNW-LDITGVFPGNYLTPL--- 478
            :|::   |:|::||.||:.|||||:||.:::|.|||.||||||.:. ....|||||||:.|:
Human   446 RPSV---YVAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPVTRA 507

  Fly   479 -----RARDQQQLMHQWK-----YVPQNADAQMAQVQQHPVA--PDVRLNNMLSMQPPDLPPR-- 529
                 :|:.......|..     ..|..|.....::|.:.||  |.|....::|.......|:
Human   508 VTNASQAKVPMSTAGQTSRGVTMVSPSTAGGPAQKLQGNGVAGSPSVVPAAVVSAAHIQTSPQAK 572

  Fly   530 -------------------------QQQATATTTSCSVWS----KPVEALFSRKSEPKPETATAS 565
                                     |::.||..|...|.:    .|.....|..|...|:.|...
Human   573 VLLHMTGQMTVNQARNAVRTVAAHNQERPTAAVTPIQVQNAAGLSPASVGLSHHSLASPQPAPLM 637

  Fly   566 TTSSSSSGAVGLMRRLTHMKTRSKSP-------GASLQQVPKEAISTNVE-FTTNPSAKLHPVHV 622
            ..|::.:.|:.:.|....:...:.:|       .|||:..|...|.|.:. ..|:|.:
Human   638 PGSATHTAAISISRASAPLACAAAAPLTSPSITSASLEAEPSGRIVTVLPGLPTSPDS------- 695

  Fly   623 RSGSCPSQLQHSQPLNETPAAKTAAQQQQFLPKQLPSASTNSVSYGSQRVKGSKERPHLICARQS 687
            .|.:|.:.       :.|...|.:.::::.|.|.|..|||             |.:|.:
Human   696 ASSACGNS-------SATKPDKDSKKEKKGLLKLLSGAST-------------KRKPRV------ 734

  Fly   688 LDAATFRSMYNNAASPPPPTT--------------SVAPAVYAGGQQQ-----VIPGGGAQSQLH 733
                          |||...|              :|.|.:..||...     .:.|.|..:...
Human   735 --------------SPPASPTLEVELGSAELPLQGAVGPELPPGGGHGRAGSCPVDGDGPVTTAV 785

  Fly   734 ANMIIAPS--HRKSHSLDASHVLSPSSNMITEAAIKASATTKSPYCTRESRFRCIVPYPPNSDIE 796
            |...:|..  |||:.|||::..::|.......:.......::...|   .|.|.:|.|||.|:.|
Human   786 AGAALAQDAFHRKASSLDSAVPIAPPPRQACSSLGPVLNESRPVVC---ERHRVVVSYPPQSEAE 847

  Fly   797 LELHLGDIIYVQRKQKNGWYKGTHARTHKTGLFPASFVE 835
            |||..|||::|.:|:::||:|||..|..||||||.||||
Human   848 LELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVE 886

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
POSH	NP_523776.1	RAD18	6..>113	CDD:227719	57/124 (46%)
		RING-HC_SH3RF3	8..53	CDD:438408	32/44 (73%)
		SH3	139..191	CDD:473055	23/51 (45%)
		SH3_SH3RF_2	199..251	CDD:212721	27/52 (52%)
		SH3_SH3RF_3	424..477	CDD:212717	30/53 (57%)
		SH3_SH3RF_C	782..836	CDD:212719	32/54 (59%)
SH3RF1	NP_065921.2	RING-HC_SH3RF1	8..55	CDD:438406	34/46 (74%)
		SH3	137..190	CDD:473055	24/52 (46%)
		SH3_SH3RF1_2	200..254	CDD:212863	27/53 (51%)
		SH3_SH3RF1_3	449..503	CDD:212859	30/56 (54%)
		PHA03247	<595..845	CDD:223021	60/299 (20%)
		SH3_SH3RF_C	833..887	CDD:212719	32/54 (59%)