Protein Alignment POSH and sorb-1

DIOPT Version :10

• Sequence 1: NP_523776.1
• Gene: POSH / 36990
• FlyBaseID: FBgn0040294
• Length: 838
• Species: Drosophila melanogaster
• Sequence 2: NP_001360603.1
• Gene: sorb-1 / 3565590
• WormBaseID: WBGene00012891
• Length: 1007
• Species: Caenorhabditis elegans
• Alignment Length: 449
• Identity: 109/449 - (24%)
• Similarity: 181/449 - (40%)
• Gaps: 103/449 - (22%)

  Fly    71 RILEGMKQNAAAGKGEEKGEETETQPERAKPQPPAESVAPP-DNQLLQLQS-----HQQSHQPAR 129
            |:.:..::.....|.|:..||...:.||.....|  |.||. .|.:.:|.|     .....:||.
 Worm   615 RVKQSNEEELLRLKAEKLAEELRKEKERKHSFIP--SSAPSLQNNMDRLNSLLYDFSSDIQEPAH 677

  Fly   130 HKQRRFLLPHAYALFDFASGEATDLKFKKGDLILIKHRIDNNWFVGQANGQEGTFPINYVKVSV- 193
            .......:..|.|::.|....|.:|...:||:|.|...:|..|..|:.||:.|.||.:||:::.
 Worm   678 RDYTPQPVMTATAVYKFEPRSARELPLNRGDIIRIIREVDGYWMEGERNGRSGIFPTSYVQINTG 742

  Fly   194 -PLPMPQCIAMYDFKMGPNDEEGCLEFKKSTVIQVMRRVDHNWAEG--RIGQTIGIFPIAFVELN 255
             .....:..|:|.|....:.|   |..|:..:|...|::|.||.||  :|| .:||||.::||
 Worm   743 NQGDSQKMRAIYPFTARSDTE---LSLKRGEIITRRRQIDSNWLEGSNQIG-IVGIFPASYVE-- 801

  Fly   256 AAAKKLLDSGLHTHPFCHPPKQQGQRALPPV-------PVID-----------PTVVTESSSG-- 300
                               |.:|.::.:|.:       |.|:           .||:.:|:.|
 Worm   802 -------------------PIEQVEQHIPTIVPNRPKTPKIEDQVYNQVYKPNETVIMQSNQGYY 847

  Fly   301 -SSNSTPG--------SSNSSSTSSSNNCSPNHQISLPNTPQHVVASGSASVRFRDKGAKEKRHS 356
             .:...|.        |.:.|:...|.:.:| ||...|  |.|...|......:   |.|:..:.
 Worm   848 DKAAVVPNNKVRFDLPSGSDSNLQISRSLNP-HQNQFP--PTHTQTSTQQPSNY---GMKKIEYE 906

  Fly   357 LNALLGGGAPLSLLQTNRHSAEILSLPHELSRLEVSSSTALKPTSAPQTSRVLKTTVQQQMQPNL 421
            ...::....|:.:.|..:.:.|                    |.:..:.:.:|......     :
 Worm   907 REKVVEEVPPMHMDQYRKLNDE--------------------PKNPKKDTNILMNAASL-----I 946

  Fly   422 PWG---YLALFPYKPRQTDELELKKGCVYIVTERCVDGWFKGKNWL--DITGVFPGNYL 475
            |.|   |.|::||:|::.|||:|....:..|.|:|.||||.|.:..  |. |:|||||:
 Worm   947 PKGSEMYRAVYPYQPQKEDELQLYTNDIIFVVEKCDDGWFIGTSLRTGDF-GIFPGNYV 1004

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
POSH	NP_523776.1	RAD18	6..>113	CDD:227719	11/42 (26%)
		RING-HC_SH3RF3	8..53	CDD:438408
		SH3	139..191	CDD:473055	19/51 (37%)
		SH3_SH3RF_2	199..251	CDD:212721	19/53 (36%)
		SH3_SH3RF_3	424..477	CDD:212717	25/57 (44%)
		SH3_SH3RF_C	782..836	CDD:212719
sorb-1	NP_001360603.1	Sorb	505..553	CDD:470634
		SH3_Sorbs_1	687..739	CDD:212715	19/51 (37%)
		SH3_Sorbs_1	749..802	CDD:212715	21/77 (27%)
		SH3_Sorbs_3	952..1006	CDD:212714	24/54 (44%)