Protein Alignment CG4853 and LTE1

DIOPT Version :10

• Sequence 1: NP_611222.2
• Gene: CG4853 / 36974
• FlyBaseID: FBgn0034230
• Length: 709
• Species: Drosophila melanogaster
• Sequence 2: NP_009378.1
• Gene: LTE1 / 851209
• SGDID: S000000022
• Length: 1435
• Species: Saccharomyces cerevisiae
• Alignment Length: 746
• Identity: 145/746 - (19%)
• Similarity: 259/746 - (34%)
• Gaps: 240/746 - (32%)

  Fly    94 SLTTTEEVLV-----SRNGQILDERTVETKENFNHQSHQKEIWHPVKQQSALARATPENALKYRT 153
            ::|.|:|:.:     :::..:::|  :...|..|.:.::|         |||...|....:   :
Yeast   791 AITPTKELSIVDPEQNKSNSVIEE--ISEIEPLNLEYNKK---------SALYSDTSSTVI---S 841

  Fly   154 TSNSTFASQATDSDERPVDPLGRQLN--QTFSNASLMSSSSAITGS-----DQVIGSVSSTTIGD 211
            .|.|.....|.:|      ||.:..|  :.|.|.:.:|.::.|..|     :.|:..::|.|.|
Yeast   842 ISTSKLFESAQNS------PLKQTQNPQREFPNGTSVSETNRIRLSIAPTIESVVSDLNSITTG- 899

  Fly   212 KSSNISSCDSGHDGLFHSVSMSAPWSHPR-------------DTL--TDSLY----CDIPSSADE 257
              |.:.:.::..|         .|..|.|             |.:  |.||:    .|:..|.::
Yeast   900 --STVETFETSRD---------LPVPHQRIINLREEYQRGNQDIISNTSSLHELKTIDLSDSNND 953

  Fly   258 SDAVSILNTHLKITEPFDCQTAPVYAKDIPKKGNLDSVVNLLINNNTKDLRFAFLTTSRLFSPPH 322
            .::.|   ||.|..:.|..          |..|::|....:   .|.::|:..||...   |..:
Yeast   954 LESPS---THAKNNKYFFS----------PDDGSIDVASPM---KNVEELKSKFLKNE---SETN 999

  Fly   323 QLLSKIIAKID-------NEEENVLRLLNEWLDTCPGDFSHELLLQELENKRNVKGLAAFLD--- 377
            ..:|..:..:|       :...|..|..:|      ..|:..|      ||:|:..:|..||
Yeast  1000 SNISGSVLTMDDIDINDTSSARNTRRANSE------SAFTGSL------NKKNLNEIANMLDDSI 1052

  Fly   378 -------------GIPQALAQKDENGRS------------------QLNNLLTKQSSASSLGRQS 411
                         |..:.:.:|.||.:|                  .||||.:.|:|.:...:..
Yeast  1053 NDDPITVALMKLEGTYEKIPEKPENTKSSDAIGIKTSKLADEVEMLNLNNLPSFQNSPAEKRKSL 1117

  Fly   412 SIKSLKRFAANVYKTDN---------------------------------------------VLN 431
            .|:..::...|:..|.:                                             :.|
Yeast  1118 LIERRRQTIMNIPFTPDQSEKEGFTSSSPEKIDVSANVDVAVQAAQIQELIGQYRIHDSRLMISN 1182

  Fly   432 NCS--------SAFELAHQLYAIEYAYLSQIRLEEFVEILEKDELKTCIS--------QTKAGTL 480
            |.|        .:..:|.|:..||...|.:|..::.:::..|.|....||        :|.:|
Yeast  1183 NESHVPFILMYDSLSVAQQMTLIEKEILGEIDWKDLLDLKMKHEGPQVISWLQLLVRNETLSG-- 1245

  Fly   481 GSNCISQVTIDSYVQWFNQLSYLTATEILKLGKKSQRAQMIDFWVETALECFNTGNFNSLMAILT 545
                     ||..:..||.......:|||.......:..:|..::..|..|....|||:||.|:.
Yeast  1246 ---------IDLAISRFNLTVDWIISEILLTKSSKMKRNVIQRFIHVADHCRTFQNFNTLMEIIL 1301

  Fly   546 ALNLTAIARLKKTWAKVQTTKFEGLEHQMDPSSNFLNYRSTMKAAVWRSEREMANEIERAI--IP 608
            ||:.:.:.:....|..::.......|......|...|| ||:        |.:.|.:...:  :|
Yeast  1302 ALSSSVVQKFTDAWRLIEPGDLLTWEELKKIPSLDRNY-STI--------RNLLNSVNPLVGCVP 1357

  Fly   609 FFSLFLKDLHAINESHETKLANGYINFEKCLHLGTQL-RNF---GKWQRLDCPYEQLPSVVSYLL 669
            |..::|.||.|..|..:..|.:..:|:.| .....|: :||   .:|.:.            |..
Yeast  1358 FIVVYLSDLSANAEKKDWILEDKVVNYNK-FDTNVQIVKNFIQRVQWSKF------------YTF 1409

  Fly   670 KAEVLSEDLLMKASYESEPPETGEEKDHYKT 700
            |   ::.:||.|..|.|  ..|.||.:...|
Yeast  1410 K---VNHELLSKCVYIS--TLTQEEINELST 1435

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4853	NP_611222.2	REM	292..>365	CDD:470601	13/79 (16%)
		RasGEF	438..638	CDD:459872	48/209 (23%)
LTE1	NP_009378.1	RasGEFN	28..156	CDD:214571
		RasGEF	1190..1434	CDD:238087	63/281 (22%)