DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4853 and LTE1

DIOPT Version :9

Sequence 1:	NP_611222.2	Gene:	CG4853 / 36974	FlyBaseID:	FBgn0034230	Length:	709	Species:	Drosophila melanogaster
Sequence 2:	NP_009378.1	Gene:	LTE1 / 851209	SGDID:	S000000022	Length:	1435	Species:	Saccharomyces cerevisiae

Alignment Length:	746	Identity:	145/746 - (19%)
Similarity:	259/746 - (34%)	Gaps:	240/746 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 SLTTTEEVLV-----SRNGQILDERTVETKENFNHQSHQKEIWHPVKQQSALARATPENALKYRT 153
            ::|.|:|:.:     :::..:::|  :...|..|.:.::|         |||...|....:   :
Yeast   791 AITPTKELSIVDPEQNKSNSVIEE--ISEIEPLNLEYNKK---------SALYSDTSSTVI---S 841

  Fly   154 TSNSTFASQATDSDERPVDPLGRQLN--QTFSNASLMSSSSAITGS-----DQVIGSVSSTTIGD 211
            .|.|.....|.:|      ||.:..|  :.|.|.:.:|.::.|..|     :.|:..::|.|.|
Yeast   842 ISTSKLFESAQNS------PLKQTQNPQREFPNGTSVSETNRIRLSIAPTIESVVSDLNSITTG- 899

  Fly   212 KSSNISSCDSGHDGLFHSVSMSAPWSHPR-------------DTL--TDSLY----CDIPSSADE 257
              |.:.:.::..|         .|..|.|             |.:  |.||:    .|:..|.::
Yeast   900 --STVETFETSRD---------LPVPHQRIINLREEYQRGNQDIISNTSSLHELKTIDLSDSNND 953

  Fly   258 SDAVSILNTHLKITEPFDCQTAPVYAKDIPKKGNLDSVVNLLINNNTKDLRFAFLTTSRLFSPPH 322
            .::.|   ||.|..:.|..          |..|::|....:   .|.::|:..||...   |..:
Yeast   954 LESPS---THAKNNKYFFS----------PDDGSIDVASPM---KNVEELKSKFLKNE---SETN 999

  Fly   323 QLLSKIIAKID-------NEEENVLRLLNEWLDTCPGDFSHELLLQELENKRNVKGLAAFLD--- 377
            ..:|..:..:|       :...|..|..:|      ..|:..|      ||:|:..:|..||
Yeast  1000 SNISGSVLTMDDIDINDTSSARNTRRANSE------SAFTGSL------NKKNLNEIANMLDDSI 1052

  Fly   378 -------------GIPQALAQKDENGRS------------------QLNNLLTKQSSASSLGRQS 411
                         |..:.:.:|.||.:|                  .||||.:.|:|.:...:..
Yeast  1053 NDDPITVALMKLEGTYEKIPEKPENTKSSDAIGIKTSKLADEVEMLNLNNLPSFQNSPAEKRKSL 1117

  Fly   412 SIKSLKRFAANVYKTDN---------------------------------------------VLN 431
            .|:..::...|:..|.:                                             :.|
Yeast  1118 LIERRRQTIMNIPFTPDQSEKEGFTSSSPEKIDVSANVDVAVQAAQIQELIGQYRIHDSRLMISN 1182

  Fly   432 NCS--------SAFELAHQLYAIEYAYLSQIRLEEFVEILEKDELKTCIS--------QTKAGTL 480
            |.|        .:..:|.|:..||...|.:|..::.:::..|.|....||        :|.:|
Yeast  1183 NESHVPFILMYDSLSVAQQMTLIEKEILGEIDWKDLLDLKMKHEGPQVISWLQLLVRNETLSG-- 1245

  Fly   481 GSNCISQVTIDSYVQWFNQLSYLTATEILKLGKKSQRAQMIDFWVETALECFNTGNFNSLMAILT 545
                     ||..:..||.......:|||.......:..:|..::..|..|....|||:||.|:.
Yeast  1246 ---------IDLAISRFNLTVDWIISEILLTKSSKMKRNVIQRFIHVADHCRTFQNFNTLMEIIL 1301

  Fly   546 ALNLTAIARLKKTWAKVQTTKFEGLEHQMDPSSNFLNYRSTMKAAVWRSEREMANEIERAI--IP 608
            ||:.:.:.:....|..::.......|......|...|| ||:        |.:.|.:...:  :|
Yeast  1302 ALSSSVVQKFTDAWRLIEPGDLLTWEELKKIPSLDRNY-STI--------RNLLNSVNPLVGCVP 1357

  Fly   609 FFSLFLKDLHAINESHETKLANGYINFEKCLHLGTQL-RNF---GKWQRLDCPYEQLPSVVSYLL 669
            |..::|.||.|..|..:..|.:..:|:.| .....|: :||   .:|.:.            |..
Yeast  1358 FIVVYLSDLSANAEKKDWILEDKVVNYNK-FDTNVQIVKNFIQRVQWSKF------------YTF 1409

  Fly   670 KAEVLSEDLLMKASYESEPPETGEEKDHYKT 700
            |   ::.:||.|..|.|  ..|.||.:...|
Yeast  1410 K---VNHELLSKCVYIS--TLTQEEINELST 1435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4853	NP_611222.2	RasGEF_N	288..365	CDD:279012	14/83 (17%)
CG4853	NP_611222.2	RasGEF	438..638	CDD:279011	48/209 (23%)
LTE1	NP_009378.1	RasGEFN	28..156	CDD:214571
LTE1	NP_009378.1	RasGEF	1190..1434	CDD:238087	63/281 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910