Protein Alignment CG4853 and CDC25

DIOPT Version :9

• Sequence 1: NP_611222.2
• Gene: CG4853 / 36974
• FlyBaseID: FBgn0034230
• Length: 709
• Species: Drosophila melanogaster
• Sequence 2: NP_013413.1
• Gene: CDC25 / 851019
• SGDID: S000004301
• Length: 1589
• Species: Saccharomyces cerevisiae
• Alignment Length: 655
• Identity: 135/655 - (20%)
• Similarity: 250/655 - (38%)
• Gaps: 170/655 - (25%)

  Fly   101 VLVSRNGQILDERTVETKEN-FNHQSHQKEIWHPVKQQSALARATPENALKYRTTSNSTFASQAT 164
            |.:|....|:.::.:|.:|| .|:.:.       :.:.:..|........|:....:..::...:
Yeast  1016 VEISNLACIIVDQLIEERENLLNYAAR-------MMKNNLTAELLKGEQEKWFDIYSEDYSDDDS 1073

  Fly   165 DSDERPV-DPLGRQ-----------------LNQTFSNASLMSSSSAITG--SDQVIGSVSSTTI 209
            ::||..: |.||.:                 |...:..:.:..|...|.|  .:.:|..::|..:
Yeast  1074 ENDEAIIDDELGSEDYIERKAANIEKNLPWFLTSDYETSLVYDSRGKIRGGTKEALIEHLTSHEL 1138

  Fly   210 GDKSSNISSCDSGHDGLFHSVSMSAPW---------SHPRDTLT---DSLYCDIPSSADESDAVS 262
            .|.:.|::...:     |.|:..:..:         .:|.:.|:   .:::.:..|:..:...|:
Yeast  1139 VDAAFNVTMLIT-----FRSILTTREFFYALIYRYNLYPPEGLSYDDYNIWIEKKSNPIKCRVVN 1198

  Fly   263 ILNTHLKITEPFDCQTAPVYAKDIPKKGNLDSVVNLLINNNTKDLRFAFLTTSRLFSPPHQLLSK 327
            |:.|.|  |:.:   |...|...||          |::|       ||.:..|........||.|
Yeast  1199 IMRTFL--TQYW---TRNYYEPGIP----------LILN-------FAKMVVSEKIPGAEDLLQK 1241

  Fly   328 IIAKIDNEEENVLRLLNEWLDTCPGDFSHELLLQELENKRNVKGLAAFLDGIPQALAQKDENGRS 392
            |..|:.||.|.                      :.::.|:.        |.: .|:.|
Yeast  1242 INEKLINENEK----------------------EPVDPKQQ--------DSV-SAVVQ------- 1268

  Fly   393 QLNNLLTKQSSASSLGRQSSIKSLKRFAANVYKTDNVLNNCSSAFELAHQLYAIE---YAYLSQI 454
                 .||:.:.|.:...||               ::.::.||||....:|..::   |.|.:|:
Yeast  1269 -----TTKRDNKSPIHMSSS---------------SLPSSASSAFFRLKKLKLLDIDPYTYATQL 1313

  Fly   455 RLEEFVEILEKD-----ELKTCISQTKAGTLGSNCISQVTIDSYVQWFNQLSYLTATEILKLGKK 514
                  .:||.|     .:..|:.:. .||...|......|..::...|.|:...:..|:|....
Yeast  1314 ------TVLEHDLYLRITMFECLDRA-WGTKYCNMGGSPNITKFIANANTLTNFVSHTIVKQADV 1371

  Fly   515 SQRAQMIDFWVETALECFNTGNFNSLMAILTALNLTAIARLKKTWAKVQTTK---FEGLEHQMDP 576
            ..|:::..::|..|..|....||:|:.||::||..:.|.||||||..|.|..   .:.|.:.||.
Yeast  1372 KTRSKLTQYFVTVAQHCKELNNFSSMTAIVSALYSSPIYRLKKTWDLVSTESKDLLKNLNNLMDS 1436

  Fly   577 SSNFLNYRSTMKAAVWRSEREMANEIERAIIPFFSLFLKDLHAINESHETKLANGYINFEKCLHL 641
            ..||:.||..:::..           :.|.:|||.::|.||        |....|..:|   ||.
Yeast  1437 KRNFVKYRELLRSVT-----------DVACVPFFGVYLSDL--------TFTFVGNPDF---LHN 1479

  Fly   642 GTQLRNFGKWQRLDCPYEQLPSVVSYLLKAEVLSE-DLLMKASYESEPPETGEEKDHYKTLKA-A 704
            .|.:.||.|..::....|::.|...:..|.:.|.: ..:::||.|:.|   ..||.:..:|:. .
Yeast  1480 STNIINFSKRTKIANIVEEIISFKRFHYKLKRLDDIQTVIEASLENVP---HIEKQYQLSLQVEP 1541

  Fly   705 RKSNT 709
            |..||
Yeast  1542 RSGNT 1546

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4853	NP_611222.2	RasGEF_N	288..365	CDD:279012	13/76 (17%)
		RasGEF	438..638	CDD:279011	53/210 (25%)
CDC25	NP_013413.1	SH3_Sdc25	62..122	CDD:212816
		RasGEFN	1117..1246	CDD:214571	30/155 (19%)
		RasGEF	1301..1543	CDD:214539	69/273 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910