Protein Alignment CG4853 and Rgl3

DIOPT Version :9

• Sequence 1: NP_611222.2
• Gene: CG4853 / 36974
• FlyBaseID: FBgn0034230
• Length: 709
• Species: Drosophila melanogaster
• Sequence 2: NP_076111.2
• Gene: Rgl3 / 71746
• MGIID: 1918996
• Length: 709
• Species: Mus musculus
• Alignment Length: 548
• Identity: 126/548 - (22%)
• Similarity: 204/548 - (37%)
• Gaps: 149/548 - (27%)

  Fly   224 DGLFHSVSMSAPWSHPRDTLTDSLYCDIPSSADESDAVSILNTHLKITEPF-DCQTAPVYAKDIP 287
            ||..:|||:....|. |.|         |..:.|.      .|.:..|:.| ..:|:.|.|.
Mouse    23 DGAVYSVSLRRQRSQ-RST---------PERSGEG------QTPIPATDTFLHYRTSKVRAL--- 68

  Fly   288 KKGNLDSVVNLLIN-NNTKDLRF--AFLTTSRLFSPPHQLLSKII----------AKIDNEEEN- 338
            :...|:.:|:.|:: :..:|..|  |||.|.|.|.|..::|..::          |.:|::...
Mouse    69 RAARLERLVHELVSGDREQDPGFVPAFLATHRAFVPTARVLGFLLPPPPPPPPPPAGVDSKRTEG 133

  Fly   339 -----------VLRLLNEWLDTCPGDFSHELLLQELENKRNVKGLAA------------FLDGIP 380
                       |:.:|..||...|.||......|.|.|.|...|.||            ..|.:.
Mouse   134 QDLNFSKNLRAVVSVLGSWLRNHPQDFRDPPDHQNLGNVRIFLGWAAPGGAEAREAEKLLEDFLK 198

  Fly   381 QALAQKDENGR---------------SQLNNLLTKQSSASSLGRQSSIKSLKRFAANVYKTDNVL 430
            :|..::.|..:               |:......::...||.|.:     |..|:.:
Mouse   199 EAKGEQTEEEKRLAWSGPPRIAQTPGSEFAEDCVEEEGPSSEGPE-----LLDFSVD-------- 250

  Fly   431 NNCSSAFELAHQLYAIEYAYLSQIRLEEFVEILEKDELKTCISQ-TKAGTLGSNCISQVTIDSYV 494
                   ::|.||..::        :|.|:.:...:.|.:..|| .:.|..|   ||. |:.:.|
Mouse   251 -------DVAEQLTLMD--------VELFLRVRSCECLGSMWSQRDRPGAAG---ISP-TVRATV 296

  Fly   495 QWFNQLSYLTATEILKLG--KKSQRAQMIDFWVETALECFNTGNFNSLMAILTALNLTAIARLKK 557
            ..||.::......:|...  ..|||||.|:.|:..|..|....||:||.|||:||....|.|||:
Mouse   297 AQFNTVTGCVLGSVLAAPGLAASQRAQRIEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKR 361

  Fly   558 TWAKVQ---TTKFEGLEHQMDPSSNFLNYRSTMKAAVWRSERE-----------MANEIERAIIP 608
            :|..|.   .:.|..|........|.|:.|:.:      |:.|           :.:::....:|
Mouse   362 SWGAVSREPLSVFRKLSQIFSDEDNHLSSRAIL------SQEETTEDDDCPSGSLPSKLPPGPVP 420

  Fly   609 FFSLFLKDLHAINESHETKLANGYINFEKCLHLGTQLRNFGKWQRLDCPYEQL------------ 661
            :...||.||..::.:....|....|||||         ...:|:.| ...:||
Mouse   421 YLGTFLTDLVMLDTALPDTLKGNLINFEK---------RRKEWEIL-ARIQQLQQRCQRYSLSPR 475

  Fly   662 PSVVSYLLKAEVLSEDLLMKASYESEPP 689
            |.:::.|.....|||:...:.|...|||
Mouse   476 PPILAALRAQRQLSEEQSYRVSRVIEPP 503

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4853	NP_611222.2	RasGEF_N	288..365	CDD:279012	24/101 (24%)
		RasGEF	438..638	CDD:279011	58/216 (27%)
Rgl3	NP_076111.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	26..55		9/44 (20%)
		REM	73..199	CDD:100121	30/125 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	203..225		1/21 (5%)
		RasGEF	244..503	CDD:214539	72/301 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	395..416		2/20 (10%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	502..604		2/2 (100%)
		Interaction with HRAS, MRAS and RIT1. /evidence=ECO:0000269|PubMed:10869344, ECO:0000269|PubMed:11313946	611..706
		RalGDS_RA	612..697	CDD:176351

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910