DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4853 and rapgef2b

DIOPT Version :9

Sequence 1:	NP_611222.2	Gene:	CG4853 / 36974	FlyBaseID:	FBgn0034230	Length:	709	Species:	Drosophila melanogaster
Sequence 2:	XP_017214661.1	Gene:	rapgef2b / 557693	ZFINID:	ZDB-GENE-030131-6959	Length:	1634	Species:	Danio rerio

Alignment Length:	747	Identity:	155/747 - (20%)
Similarity:	272/747 - (36%)	Gaps:	223/747 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 EEVLLVNGVPVKLDGLPADDASAIKAALLEGQMPSVEHLNQLLFRAGLAQQPIEVETSLTVKSSL 95
            :::|.|||  ...:.:|...|:.|        :.:..||                  |:|||::|
Zfish   592 DQILEVNG--QNFENVPLSKANEI--------LKNNTHL------------------SITVKTNL 628

  Fly    96 TTTEEVLVSRNGQILDERTVETKENFNHQSHQKEIWHPVKQQSALARATPENALKYRTTSNSTFA 160
            ...:| |::|..|..::...|..:..|...|..:| ..:|:.|           :|.....:...
Zfish   629 LVFKE-LLARPDQDQEQEQEEEPDRKNGAPHIPKI-GDIKKAS-----------RYSIPDLAVDV 680

  Fly   161 SQATDSDERPVDPLGRQLNQTFSNASLMSSSSAITGSDQVIGSVSSTTIGDKSSNISSCDSGHDG 225
            .|..|.::                ||..:.:::..|.:::      ..|.||
Zfish   681 EQVMDLEK----------------ASKKAKANSAGGRNKL------KKIFDK------------- 710

  Fly   226 LFHSVSMSAPWSHPRDTLTDSL----YCDIPSSADESDAVSILNTHLKITEPFDCQTAPVYAKDI 286
                            |||..|    |.|:.....:.|::    ..||.::    |..|.    :
Zfish   711 ----------------TLTSILPPKPYNDVGVGQSQDDSI----VGLKQSK----QIPPA----L 747

  Fly   287 PKKGNLDSVVNLLINNNTKDLRFAFLTTS----------RLFSPPHQLLSKIIAKIDNEEENVLR 341
            |..|||.|....|:.::.:.|.|.....:          |:|....|....:|.|....:|.|.:
Zfish   748 PVSGNLSSSNPDLLQSHHRILDFNNQPEAVPINMSDQVLRVFKADQQSRYIMIGKDTTAKEVVAQ 812

  Fly   342 LLNEWLDT--------CPGDFSHELLLQELENKRNVKGLAAFLDGIPQALAQKDENGRSQLNN-- 396
            .:.|:..|        |....:.|.::::   :|..:.|:...|.|       ..:||..|.:
Zfish   813 AIREFALTAAAEAYSLCEVSVTPEGVIKQ---RRLPEQLSKLADRI-------QLSGRYYLKSNM 867

  Fly   397 ---LLTKQSSASSLGRQSSIKSLKRFAANVYKTDNVLNNCSSAFELAHQLYAIEYAYLSQIRLEE 458
               .|.....|..|.|:|.|..|:                .|..|:|.||....:.....|...|
Zfish   868 ETETLCSDEDAQELLRESHISLLQ----------------LSTVEVATQLSMRAFELFCAIEPTE 916

  Fly   459 FVEILEKDELKTCISQTKAGTLGSNCISQVTIDSYVQWFNQLSYLTATEILKLGKKSQRAQMIDF 523
            :::.|.|  |||.::...:..|....|::.|.     |       .|||:::...:.:|.:::..
Zfish   917 YIDDLFK--LKTRLTGPPSLKLFEEAINRETF-----W-------VATEVVREANQLKRMKIVKH 967

  Fly   524 WVETALECFNTGNFNSLMAILTALNLTAIARLKKTWAKVQT---TKFEGLEHQMDPSSNFLNYRS 585
            :::.||.|....||||:.||::.|||..::||:.||.|:.:   ..|..|:...|||.|...||:
Zfish   968 FIKIALHCRECKNFNSMFAIISGLNLAPVSRLRGTWEKLPSKYEKLFSDLQDLFDPSRNMAKYRN 1032

  Fly   586 TMKAAVWRSEREMANEIERAIIPFFSLFLKDLHAINESHETKLANGYINFEKCLHLGTQLRNFG- 649
            .:.          :..::..|||.|.:..|||..::|.:::|: :|.:||||...:..::|:.|
Zfish  1033 LLN----------SQNLQPPIIPLFPVIKKDLTFLHEGNDSKV-DGLVNFEKLRMIAKEIRHVGR 1086

  Fly   650 -----------------KWQRLDCPYEQLPSVV----------------SYLLKAEVLSEDLLM- 680
                             ||:.|....:...:..                |..|.|:.|.||..|
Zfish  1087 MAAVNMDPALMFRTRKKKWRSLGSLSQGSANAAVLDVTQTGGHKKRVRRSSFLNAKKLYEDAQMA 1151

  Fly   681 ---KASYESEPPETGEEKDHYKTLKAARKSNT 709
               |....:...||.||.....:::.....||
Zfish  1152 RKVKQYLSNLTLETNEESLQTLSMQCEPSINT 1183

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4853	NP_611222.2	RasGEF_N	288..365	CDD:279012	18/94 (19%)
CG4853	NP_611222.2	RasGEF	438..638	CDD:279011	57/202 (28%)
rapgef2b	XP_017214661.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910