Protein Alignment CG4853 and Rasgrf1

DIOPT Version :9

• Sequence 1: NP_611222.2
• Gene: CG4853 / 36974
• FlyBaseID: FBgn0034230
• Length: 709
• Species: Drosophila melanogaster
• Sequence 2: NP_035375.1
• Gene: Rasgrf1 / 19417
• MGIID: 99694
• Length: 1262
• Species: Mus musculus
• Alignment Length: 583
• Identity: 131/583 - (22%)
• Similarity: 218/583 - (37%)
• Gaps: 138/583 - (23%)

  Fly   160 ASQATDSD-----ERPVDPLGRQLNQTFSNASLMSSSSAITGSDQVIGSVSSTTIGDKSSNISSC 219
            ||....||     ..|:.|.|:   .|.....|..:||.....:::  .|.: ||.:|..
Mouse   760 ASLGCSSDSYANIHSPISPFGK---TTLDTGKLCMASSLPKTPEEI--DVPA-TIPEKPG----- 813

  Fly   220 DSGHDGLFHSVSMSAPWSHPRDTLTDSLYCDIPSSADESDAVSILNTHLKITEPFDCQTAPVYAK 284
                       .:||...|..|.|.:....|...|.:::..||                 ||.:.
Mouse   814 -----------ELSASRKHSSDVLKEESEDDQNHSDEDNTEVS-----------------PVKSP 850

  Fly   285 DIPK----------------KGNLDSVVNLLINNNTKDL----RFAFLTTSRLFSPPHQLLSKII 329
            ..||                .|.|.:....|::||...|    .||..|......|.::.:.:.:
Mouse   851 PTPKSFLNRTITEFPFFNYNNGILMTTCRDLVDNNRSTLSATSAFAIATAGANEGPSNKEVFRRM 915

  Fly   330 A-----------KIDNE-------EENVLRLLNEWLDTCPGDFSHELLLQELENKRNVKGLAAFL 376
            :           .||.|       ...||.:|..|:.....||..:..|:        ..:..||
Mouse   916 SLANTGFSSDQRNIDKEFVIRRAATNRVLNVLRHWVTKHTQDFDTDDTLK--------YRVICFL 972

  Fly   377 DGI---PQALAQKDENGRSQLNNLLTKQSSASSLGRQSSIKSLKRFAANVYKTDNVLNNCSSAFE 438
            :.:   |..|.|:    |....|::...:...:..:.|.::.:......| ||:...|:  .|.|
Mouse   973 EEVMHDPDLLTQE----RKAAANIIRTLTLEETTEQHSMLEEVILMTEGV-KTEPFENH--PALE 1030

  Fly   439 LAHQLYAIEYAYLSQIRLEEFV----EILEKDELKTCISQTKAGTLGSNCISQVTIDSYVQWFNQ 499
            :|.||..:::.....|..|||.    ...||.|....|.:|                  .:.||.
Mouse  1031 IAEQLTLLDHLVFKSIPYEEFFGQGWMKAEKYERTPYIMKT------------------TKHFNH 1077

  Fly   500 LSYLTATEILKLGKKSQRAQMIDFWVETALECFNTGNFNSLMAILTALNLTAIARLKKTWAKV-Q 563
            :|...|:||::....|.||..|:.||..|..|....|:|:::.|.:::|.:||.||||||.|| :
Mouse  1078 VSNFIASEIIRNEDISARASAIEKWVAVADICRCLHNYNAVLEITSSINRSAIFRLKKTWLKVSK 1142

  Fly   564 TTK--FEGLEHQMDPSSNFLNYRSTMKAAVWRSEREMANEIERAIIPFFSLFLKDLHAINESHET 626
            .||  .:.|:..:.....|.|.|.:::            ..:...:|:..::|.||..|.|....
Mouse  1143 QTKSLLDKLQKLVSSDGRFKNLRESLR------------NCDPPCVPYLGMYLTDLVFIEEGTPN 1195

  Fly   627 KLANGYINFEKCLHLGTQLRNFGKWQRLDCPYEQLPSVVSYLL-KAEVLSEDLLMKASYESEP 688
            ...:|.:||.|...:...:|...::|:.....:..|.|:.||| ::.:|.|:.|.::|...||
Mouse  1196 YTEDGLVNFSKMRMISHIIREIRQFQQTTYKIDPQPKVIQYLLDESFMLDEESLYESSLLIEP 1258

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4853	NP_611222.2	RasGEF_N	288..365	CDD:279012	21/114 (18%)
		RasGEF	438..638	CDD:279011	56/206 (27%)
Rasgrf1	NP_035375.1	PH-like	19..155	CDD:302622
		PH	24..130	CDD:278594
		RhoGEF	248..429	CDD:214619
		PH-like	435..586	CDD:302622
		PH	482..587	CDD:278594
		RasGEF_N	638..>687	CDD:279012
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	714..738
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	800..854		15/89 (17%)
		REM	<927..996	CDD:295342	17/80 (21%)
		RasGEF	1023..1259	CDD:214539	72/268 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910