DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4853 and rgef-1

DIOPT Version :9

Sequence 1:	NP_611222.2	Gene:	CG4853 / 36974	FlyBaseID:	FBgn0034230	Length:	709	Species:	Drosophila melanogaster
Sequence 2:	NP_505469.3	Gene:	rgef-1 / 179344	WormBaseID:	WBGene00009100	Length:	654	Species:	Caenorhabditis elegans

Alignment Length:	447	Identity:	100/447 - (22%)
Similarity:	168/447 - (37%)	Gaps:	134/447 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   314 TSRLFSPPHQLL---SKIIAK------IDNEEE-------NVLRLLNEWLDTCPGDFSHELLLQE 362
            :|::....||.|   .:::|:      :|.|:|       :.|.|.::||.......:|  .:..
Worm     2 SSKVEEDQHQELLTEDQLVARCVECFDVDEEDEVEDIEFVDALFLSHQWLSDSLSLITH--FVNF 64

  Fly   363 LENKRNVKGLAA--------------FLDGIPQALAQK----------DENGRSQLN-------- 395
            .:..|||:...|              ..|..||..||.          :||.|:.|:
Worm    65 YQETRNVEQREAVCRAVSFWIEKFPMHFDAQPQVCAQVVRLKTIAEDINENIRNGLDVSALPSFA 129

  Fly   396 --------NLLTKQSSASSLGRQSSIKSLKRFAANVYKTDNVLNNCSSAFELAHQLYAIEYAYLS 452
                    |.|.||::.|....|:|...:                   :..|:|    |:|..||
Worm   130 WLRAVSVRNPLAKQTAFSLSFVQASPSDI-------------------STSLSH----IDYRVLS 171

  Fly   453 QIRLEEFVEILEKDELKTCISQTKAGTLGSNCISQVTIDSYVQWFNQLSYLTATEILKLGKKSQR 517
            :|.:.|..:.::...|::|                ..::..:..||.||......||......:|
Worm   172 RISITELKQYVKDGHLRSC----------------PMLERSISVFNNLSNWVQCMILNKTTPKER 220

  Fly   518 AQMIDFWVETALECFNTGNFNSLMAILTALNLTAIARLKKTWA------KVQTTKFEGLEHQMDP 576
            |:::..:|..|.......|||:||:::..:..:::|||.||:|      |.:.|:...|   :..
Worm   221 AEILVKFVHVAKHLRKINNFNTLMSVVGGITHSSVARLAKTYAVLSNDIKKELTQLTNL---LSA 282

  Fly   577 SSNFLNYRSTMKAAVWRSEREMANEIERAIIPFFSLFLKDLHAINES----HETKLANGYINFEK 637
            ..||..||..:.|         .|:..|  ||...:.||||.|||.|    .:||.    |:.:|
Worm   283 QHNFCEYRKALGA---------CNKKFR--IPIIGVHLKDLVAINCSGANFEKTKC----ISSDK 332

  Fly   638 CLHLGTQLRNFGKWQRLDCPYEQLPSVVSYLLKAEVLSEDL------LMKASYESEP 688
            .:.|...|.||..:.:..   ..||.:...|:....:|.|:      :.:.|...||
Worm   333 LVKLSKLLSNFLVFNQKG---HNLPEMNMDLINTLKVSLDIRYNDDDIYELSLRREP 386

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4853	NP_611222.2	RasGEF_N	288..365	CDD:279012	13/66 (20%)
CG4853	NP_611222.2	RasGEF	438..638	CDD:279011	54/209 (26%)
rgef-1	NP_505469.3	RasGEF	150..388	CDD:214539	69/297 (23%)
		EFh	423..473	CDD:238008
		EF-hand_7	427..477	CDD:290234
		C1	493..542	CDD:237996
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910