DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4853 and pxf-1

DIOPT Version :9

Sequence 1:	NP_611222.2	Gene:	CG4853 / 36974	FlyBaseID:	FBgn0034230	Length:	709	Species:	Drosophila melanogaster
Sequence 2:	NP_001023389.1	Gene:	pxf-1 / 177894	WormBaseID:	WBGene00004254	Length:	1470	Species:	Caenorhabditis elegans

Alignment Length:	759	Identity:	159/759 - (20%)
Similarity:	270/759 - (35%)	Gaps:	216/759 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 DGLPADDASAIK---------AALLEGQMPSVEHLNQLLFRAGLAQQPIEVETSLT-----VKSS 94
            |||..:..|.::         ..|::|:...:.|  .|:........|..|:..|.     ::..
Worm   459 DGLTGEVVSEVERRTVGTHCGQVLIKGKPDKLIH--HLVDERDHNVDPHYVDDFLLTYRVFIRDP 521

  Fly    95 LTTTEEVLVSRNGQILDERTVE-----TKENFNHQSHQKEIWHPVKQ-QSALAR----------- 142
            .|..|::::.....|..::...     ...:||......|:|:.::: :.||.|
Worm   522 TTIFEKLMLWFADSIYRDKVARLVLLWVNNHFNDFETNDEMWNLLERFEGALERDGMHSQLSLLN 586

  Fly   143 ------ATPENALKYR--------------TTSNSTFASQA---TDSDERPVDPLGRQLNQTFSN 184
                  |.|...:..|              .:.||.:.::.   |.:....|......|.....:
Worm   587 IACSVKAKPRQVILTRRKDDKMMMRLVGGQESGNSVYVAEVFPDTSAAREGVKRADEMLEVNQQS 651

  Fly   185 ASLMSSSSAITGSDQVIGSVSST------------TIGDKSSNISSCDSGHDGL-------FHSV 230
            |..:|:..|   .|.:.||:|.|            |||....|.....:...|.       .|..
Worm   652 AKYLSAKKA---EDLLTGSLSLTLMLKNNVLGYKETIGKIEHNKPKNGTSRSGAGIPMVIPVHKT 713

  Fly   231 SMSAPWS---HPRDTLTDSLYCDIPSSADES----DAVSILNTHLKITEPFDCQTAPVYAKDIPK 288
            |::...|   ..:..:.:.|...:.||.::|    |...|.:..|:                 |.
Worm   714 SITGKKSSTTSSKSGMMEKLMTILKSSKEDSMDFTDEAKISSADLR-----------------PS 761

  Fly   289 KGNLDSVVNLLINNNTKDLRFAFLTTSRLFSPPHQLLSKIIAKI--------------DNEEENV 339
            :.|.|                 ..:.|:.:.|......:.:.||              :...:||
Worm   762 RSNPD-----------------ITSISQYYGPVRSECPEHVLKIYRNDQTFKYLPVYKETSAQNV 809

  Fly   340 LRL-LNEWLDTCPGDFSHELLLQELENKRNVKGLAAFLDGI-------PQA--LAQKDE-NGRSQ 393
            ::| |.|:..|..|  |.|..|.|         ....:||:       ||.  ||::.. |.|..
Worm   810 VQLALQEFNMTAEG--SPEWSLCE---------CTVTIDGVIKQRRLPPQMENLAERIALNSRYY 863

  Fly   394 LNN-----LLTKQSSASSLGRQSSIKSLKRFAANVYKTDNVLNNCSSAFELAHQLYAIEYAYLSQ 453
            |.|     .|.....|..|.:::..:.|.            ||    |..:|.||...:::..|.
Worm   864 LKNNSRSEPLVPDELAPELLKEAQTQLLS------------LN----AQVVAAQLTLQDFSVFSA 912

  Fly   454 IRLEEFVEILEKDELKTCISQTKAGTLGSNCISQVTIDSYVQWFNQLSYLTATEILKLGKKSQRA 518
            |...||::.|.|.:.|          .||     ..::.:.|.||:..:..||||.......:||
Worm   913 IEPTEFLDNLFKLDSK----------YGS-----PKLEEFEQLFNREMWWVATEICTERHVQKRA 962

  Fly   519 QMIDFWVETALECFNTGNFNSLMAILTALNLTAIARLKKTWAKVQTTKFEGLE--HQM-DPSSNF 580
            ::|..:::.|..|.:..||||:.||::.|:..|:.||..:|.:|.:.....|:  ||: |||.|.
Worm   963 KLIKKFIKVARYCRDLRNFNSMFAIMSGLDKPAVRRLHSSWERVSSKYIRMLDEIHQLVDPSRNM 1027

  Fly   581 LNYRSTMKAAVWRSEREMANEIERAIIPFFSLFLKDL---HAINESHETKLANGYINFEKCLHLG 642
            ..||..:        .|:|.  |..::|.:.:..|||   |..|.::..||    |||||...:.
Worm  1028 SKYRQHL--------AEVAQ--EPPVVPIYPVIKKDLTFAHDGNATYSEKL----INFEKLRLIA 1078

  Fly   643 TQLRNFGKWQRLDCPYEQLPSVVSYLLKAEVLSEDLLMKASYES 686
            ..:|  |..:....||| :.|:..  ....|:.:.||...|:|:
Worm  1079 KSIR--GVMKLSSAPYE-IASMAE--RSGGVVMDALLHMNSFEN 1117

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4853	NP_611222.2	RasGEF_N	288..365	CDD:279012	17/91 (19%)
CG4853	NP_611222.2	RasGEF	438..638	CDD:279011	60/205 (29%)
pxf-1	NP_001023389.1	CAP_ED	45..131	CDD:237999
		cNMP	348..458	CDD:197516
		RasGEFN	479..592	CDD:214571	17/114 (15%)
		PDZ_signaling	595..662	CDD:238492	10/69 (14%)
		PDZ_GEF_RA	782..867	CDD:176380	22/95 (23%)
		RasGEF	890..1118	CDD:238087	76/278 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910