Protein Alignment CG4853 and AgaP_AGAP000614

DIOPT Version :9

• Sequence 1: NP_611222.2
• Gene: CG4853 / 36974
• FlyBaseID: FBgn0034230
• Length: 709
• Species: Drosophila melanogaster
• Sequence 2: XP_310467.4
• Gene: AgaP_AGAP000614 / 1271618
• VectorBaseID: AGAP000614
• Length: 839
• Species: Anopheles gambiae
• Alignment Length: 940
• Identity: 222/940 - (23%)
• Similarity: 326/940 - (34%)
• Gaps: 419/940 - (44%)

  Fly    21 DCETSSSLQQEEVLLVNGVPVKLDGLPAD------DASAIKAALLEGQMPSVEHLNQLLFR---- 75
            |...|.::.:||:||:||:||:|....||      ||::|:.||..|::||:..||:::.:
Mosquito    57 DITQSRTVHEEEILLINGIPVRLPAESADHGAVDEDAASIRDALRAGEIPSIVVLNRIIEKLHRS 121

  Fly    76 ---AGLAQQPIEVETSLTVKSSLTTTEEVLVSRNG---------------------QILDERTVE 116
               .||.   :.|||||||.:...|||..:|...|                     |:...||||
Mosquito   122 SPGPGLV---VAVETSLTVSNCRKTTETCVVQPIGSGRPGDPVLDPWEVTEERMEKQLYSSRTVE 183

  Fly   117 TKENF--NHQ----------------SHQKEIWHPVKQQSALARATPENALKYRTTSNSTFASQA 163
            ..|..  ::|                ::||..|                      .|.|..:.|.
Mosquito   184 MTEGIGGSYQRGVADGGGGGAGAGRLANQKRCW----------------------PSGSVDSGQW 226

  Fly   164 TDSDERPVDPLGRQLNQTFSNASLMSSSSAITGSDQVI-----GSVSSTTIGDKSSNISSCDSGH 223
            |::|..|      ::.||..:.:|.:.      :|.::     |::.|.|:
Mosquito   227 TETDAPP------EVRQTTVDPALYAK------ADDLLLHYTEGNLISGTL-------------- 265

  Fly   224 DGLFHSVSMSAPWSHPRDTLTDSLYCDIPSSADESDAVSILNTHLKITEPFDCQTAPVYAKDIPK 288
            :||.                                      ||...|..:           :|.
Mosquito   266 EGLL--------------------------------------THFTPTGSY-----------LPD 281

  Fly   289 KGNLDSVVNLLINNNTKDLRFAFLTTSRLFSPPHQLLSKII-AKIDN-EEENVLRLLNEWLDTCP 351
            :..:                |.||..:|.|..|.::|.:.: |.|.| ...|:..||..|::..|
Mosquito   282 RSFI----------------FTFLLAARQFLRPDEILERTLRAAISNGGTANLPHLLAAWMNDFP 330

  Fly   352 GDFSHELLLQELENKRNVKGLAAFLDGIPQALAQKDENGRSQLNNLLTKQSSASSLG-------- 408
            .||..|.::                                :|....|:|.||...|
Mosquito   331 YDFRDERMM--------------------------------RLVRSFTEQQSAGGGGPPPPTGRP 363

  Fly   409 -----------RQSSIKSLKRFAANV------------------------YKTDNVLNNCSSAFE 438
                       |.:..::|:|.|..:                        :||...|...:|...
Mosquito   364 HDPPDRGKARERSTLSRALRRLAHRLAKLERYEVEKGPLGPPAKGGGLDDWKTAPALVELASGSP 428

  Fly   439 --LAHQLYAIEYAYLSQIRLEEFVEILEKDELKTCISQTKAGTLGSNCISQVTIDSYVQWFNQLS 501
              :|:.|.|||....|.|.||||.....:....:|...|  |..|||.:      :||||:|:|:
Mosquito   429 VLMANTLTAIEAERFSFIGLEEFFPPSGQSAGASCYRGT--GPTGSNLL------AYVQWYNRLT 485

  Fly   502 YLTATEILKLGKKSQRAQMIDFWVETALECFNTGNFNSLMAILTALNLTAIARLKKTWAKVQTTK 566
            |:.||:||:..:|..||:.::||:||..||||.|||||||||:..|....|.||||||.||.::.
Mosquito   486 YVVATDILRSPRKRHRARAVEFWIETGRECFNRGNFNSLMAIIATLTGGPIGRLKKTWTKVTSSS 550

  Fly   567 ---FEG---------------------------------LEHQMDPSSNFLNYRSTMKAAVWRS- 594
               ..|                                 ||||.||::||..||:|:.||.|||
Mosquito   551 SSLLSGMTSSSMISSASGIGNSSSTCSSAAGGGRQQLAILEHQADPTNNFATYRATLHAAAWRSC 615

  Fly   595 ---------EREMANEIER----------------------AIIPFFSLFLKDLHAINE------ 622
                     ....:::..|                      |::|||||.|||||.:||
Mosquito   616 PASARSSSTSSSSSSKSSRHNSSCSSDDGQGPTSAKKGSAVAVLPFFSLLLKDLHFLNETSGNRF 680

  Fly   623 ----------------------SHETKLANGYINFEKCLHLGTQLRNFGKWQRLDCPYEQL---- 661
                                  |....|.||:|||:|...||.:|....:||| ...|::.
Mosquito   681 SDPYSKYHSFISLLILVTNCPFSCRCSLPNGHINFDKWRQLGERLSEVRRWQR-QSSYQRRCRVG 744

  Fly   662 ---PSVVSYLLKAEV---------------------------------------------LSED- 677
               .||.|    |||                                             .::|
Mosquito   745 RRHKSVTS----AEVAALRDAIERGPTIGDRETAAMHDASTKASTGRDQLDAGGGGGGGGANDDG 805

  Fly   678 -----LLMKASYESEPPETGEEKDHYKTLK 702
                 .|.|.|||.|.||...||.|:|:|:
Mosquito   806 ERGAAALAKVSYEREAPEGAVEKSHWKSLQ 835

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4853	NP_611222.2	RasGEF_N	288..365	CDD:279012	18/78 (23%)
		RasGEF	438..638	CDD:279011	96/297 (32%)
AgaP_AGAP000614	XP_310467.4	REM	264..348	CDD:100121	27/194 (14%)
		RasGEF	431..719	CDD:279011	97/295 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	171	1.000	Domainoid score	I7733
eggNOG	1	0.900	-	-		E1_KOG3541
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001827
OrthoInspector	1	1.000	-	-		otm50825
Panther	1	1.100	-	-	O	PTHR23113
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1189
TreeFam	1	0.960	-	-
	9	8.870