DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4853 and rapgef4b

DIOPT Version :9

Sequence 1:	NP_611222.2	Gene:	CG4853 / 36974	FlyBaseID:	FBgn0034230	Length:	709	Species:	Drosophila melanogaster
Sequence 2:	NP_001108368.1	Gene:	rapgef4b / 100141331	ZFINID:	ZDB-GENE-080219-4	Length:	427	Species:	Danio rerio

Alignment Length:	300	Identity:	57/300 - (19%)
Similarity:	96/300 - (32%)	Gaps:	108/300 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   407 LGRQSSIKSLKRFAANVYKTDNVLNNCSSAFELAHQLYAIEYAYLSQIRLEEFVEILEKDELKTC 471
            |.|...:|:.::|..|:                           |.||.:..|.|.|||.
Zfish    36 LARLKGVKAFEKFHPNL---------------------------LQQICMCGFYEYLEKG----- 68

  Fly   472 ISQTKAGTLGSNCISQVTIDSYVQWFNQLSYLTATEILKLGKKSQRAQMIDFWVETALECFNTGN 536
            |:..:.|.:|::            |:..||.....::.:.........:....|.||
Zfish    69 ITLYRQGDIGTS------------WYAVLSGSLDVKVSETANHQDAVTICTLGVGTA-------- 113

  Fly   537 FNSLMAILTALNLTAIARLKKTWAKVQTTKFEGLEHQMDPSSNFLNYRSTMKAAVWRSERE-MAN 600
            |...:...|..:.|.::|......:::..:|:.|                     |...|: ||.
Zfish   114 FGESILDNTPRHATIVSRENSELLRIEQREFKTL---------------------WEKYRQCMAG 157

  Fly   601 EIERAIIPFFSLFLKDLHAINESHETK--LANGYINFEKCLHLGTQLRNFGKWQRLDCPYEQLPS 663
                .:.|.:.:.  |..|.|.....|  |:|..:||        ..:|..|          :||
Zfish   158 ----LLAPPYGVM--DSGATNGRMPDKDNLSNDPLNF--------MSKNLNK----------VPS 198

  Fly   664 VVSYLLKAE-VLSEDLLMKASYESEPPETGEEKDHYKTLK 702
              ..:|:|| ||...:|.:|     |....:.|.|.||.:
Zfish   199 --EKILRAEKVLRNAILARA-----PHMIRDRKYHLKTYR 231

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4853	NP_611222.2	RasGEF_N	288..365	CDD:279012
CG4853	NP_611222.2	RasGEF	438..638	CDD:279011	36/202 (18%)
rapgef4b	NP_001108368.1	CAP_ED	44..153	CDD:237999	26/181 (14%)
		Crp	65..>153	CDD:223736	19/133 (14%)
		DEP_Epac	204..332	CDD:239884	11/32 (34%)
		CAP_ED	356..>406	CDD:237999
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910