Protein Alignment Tes and PRICKLE3

DIOPT Version :10

• Sequence 1: NP_611215.1
• Gene: Tes / 36965
• FlyBaseID: FBgn0034223
• Length: 816
• Species: Drosophila melanogaster
• Sequence 2: NP_006141.2
• Gene: PRICKLE3 / 4007
• HGNCID: 6645
• Length: 615
• Species: Homo sapiens
• Alignment Length: 812
• Identity: 147/812 - (18%)
• Similarity: 207/812 - (25%)
• Gaps: 476/812 - (58%)

  Fly    24 SRREQLKRS-KLGHEAGAGAPCAECKDKCPGLDLHFWRKVCRNCKCPKIQ---HVCPDD------ 78
            |||.:..|: ....:...|.||..|:::|||..||.|||:|::||||:.:   |..|.|
Human     6 SRRRRSGRAPPEAEDPDRGQPCNSCREQCPGFLLHGWRKICQHCKCPREEHAVHAVPVDLERIMC 70

  Fly    79 ------------DDATGWAQFEILGQIRAKPAYIKIKALASQPVQLEWVPPNAAPDVVTDYMEKL 131
                        ||.:|.|..|                       ..||||...|:.|..:...|
Human    71 RLISDFQRHSISDDDSGCASEE-----------------------YAWVPPGLKPEQVYQFFSCL 112

  Fly   132 GTAQIPVAGSDAALKRKMQLELQVPPHDLDAALCDGLTETEAIQLQQYVQKLREQCVGQGVVVRL 196
            ...::|...|.....|..||..|:||||.:|..|..|.|.|..:|:.:.|:.:.:.:|:|:|
Human   113 PEDKVPYVNSPGEKYRIKQLLHQLPPHDSEAQYCTALEEEEKKELRAFSQQRKRENLGRGIV--- 174

  Fly   197 GDRLNHAQVEHVAPALMPTQEAQQTWQSLGLMPVADDTLNELLANPKVAQALASPASAHPKLLVA 261
                                                                             
Human   175 ----------------------------------------------------------------- 174

  Fly   262 FSEPLCESTAQFEENGALRAQTREKLLGISKPALLSLVTHGIVYDKVLGILQEKKLNISRDPKLG 326
                                                                             
Human   175 ----------------------------------------------------------------- 174

  Fly   327 PIAEFRKEYVNNPQFRAEINTICPQPPMTPIKSPPGTPFNSPLPLKNPVQIRMGAQMRQDTPMRR 391
                                                                             
Human   175 ----------------------------------------------------------------- 174

  Fly   392 VKFGGVSTIVYDCGLPANTDYDRDPVFAQILQAEPLKHAFQEARAGRAPSSVVISNIPAPVASLA 456
                                                                             
Human   175 ----------------------------------------------------------------- 174

  Fly   457 ELRGLNPATRAQLQSVGLDKNMLQSAVSNAPYYDRLFRSLHDKGISHDQCHLLQPMKQVHDWLLD 521
                                              |:|
Human   175 ----------------------------------RIF---------------------------- 177

  Fly   522 DDQLLDEIDKVFADMANGCKDISYPKPSLGELPTSQSSDSGFHSKPPTPGYGSEDLTAGQGRFAS 586
                                                         |.|
Human   178 ---------------------------------------------PVT----------------- 180

  Fly   587 IPGIEDMNMYPSCAGMPEQFQQLRLHGDEASGKNSTRTILCADCNQPIAMGEVAVKADRAGKEIA 651
            |.|                                   .:|.:|.:.|..|::||.|.|||....
Human   181 ITG-----------------------------------AICEECGKQIGGGDIAVFASRAGLGAC 210

  Fly   652 WHPGCFKCITCRELLADLVYFFHQGQVFCGRDLAIRLKIPRCRACDELIFTKEYTAAEEATFHIK 716
            |||.||.|.||:|||.||:||:|.|:|:|||..|..|: |||:||||:||:.|.|.||...:|:.
Human   211 WHPQCFVCTTCQELLVDLIYFYHVGKVYCGRHHAECLR-PRCQACDEIIFSPECTEAEGRHWHMD 274

  Fly   717 HFCCYQCDEPLAGQQYIADEKSNMPLCLLCYDRLFAVRCQRCKVAIGPADQG-VAWGDVHWHAS- 779
            ||||::|:..|.||:|:.  :.:.|.|..||:...|..|..|...|| .||| :|:...|||||
Human   275 HFCCFECEASLGGQRYVM--RQSRPHCCACYEARHAEYCDGCGEHIG-LDQGQMAYEGQHWHASD 336

  Fly   780 -CFVCAGVQCSKPLIGGRFCVKENMPFCSPTC 810
             ||.|:  :|.:.|:|..|..:..:.|||..|
Human   337 RCFCCS--RCGRALLGRPFLPRRGLIFCSRAC 366

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tes	NP_611215.1	PET_testin	110..197	CDD:193604	27/86 (31%)
		LIM1_Testin_like	627..684	CDD:188726	31/56 (55%)
		LIM2_Testin_like	691..748	CDD:188727	26/56 (46%)
		LIM	755..810	CDD:413332	23/57 (40%)
PRICKLE3	NP_006141.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..26		5/19 (26%)
		PET_Prickle	82..178	CDD:193602	34/488 (7%)
		LIM1_Prickle	186..244	CDD:188799	31/57 (54%)
		LIM2_Prickle	249..304	CDD:188802	26/56 (46%)
		LIM3_Prickle	309..367	CDD:188804	24/61 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	396..567
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	587..615