Protein Alignment Tes and LIMCH1

DIOPT Version :10

• Sequence 1: NP_611215.1
• Gene: Tes / 36965
• FlyBaseID: FBgn0034223
• Length: 816
• Species: Drosophila melanogaster
• Sequence 2: XP_011511944.1
• Gene: LIMCH1 / 22998
• HGNCID: 29191
• Length: 1655
• Species: Homo sapiens
• Alignment Length: 788
• Identity: 151/788 - (19%)
• Similarity: 242/788 - (30%)
• Gaps: 280/788 - (35%)

  Fly     5 SPNSCVETPKA-----PEWLSKLESRREQLKRSKLGHEAGAGAPCAECKDKCPGLDLHFWRKVCR 64
            ||:..| ||||     |:..|:.::.::.||..|:           :.|....|..:|  |:..:
Human  1067 SPSKTV-TPKAVPMLTPKPYSQPKNSQDVLKTFKV-----------DGKVSVNGETVH--REEEK 1117

  Fly    65 NCKCPKIQHVCPDDDDATGWAQFEILGQIRAKPAYIK---------IKALASQPVQL----EWVP 116
            ..:||.:...    ...|....||.:.::...|..:|         ||...|.|.:|    |...
Human  1118 ERECPTVAPA----HSLTKSQMFEGVARVHGSPLELKQDNGSIEINIKKPNSVPQELAATTEKTE 1178

  Fly   117 PNAAPDVVTDYMEKLGTAQIPVAGSDAALKRKMQLEL--QVPPH-DLDAALCDGLTETEAI---- 174
            ||:..|                 .:|....||..:||  ..|.| ......|   :.|.|.
Human  1179 PNSQED-----------------KNDGGKSRKGNIELASSEPQHFTTTVTRC---SPTVAFVEFP 1223

  Fly   175 ---QLQQYVQKLREQCVGQGVVVRLGDRLNHAQVEHVAPALMPTQEAQQTWQSLGLMPVADDTLN 236
               ||:..|.:.::|...:.   .:..::.....:.|.....|..||..|:..|..||.|    |
Human  1224 SSPQLKNDVSEEKDQKKPEN---EMSGKVELVLSQKVVKPKSPEPEATLTFPFLDKMPEA----N 1281

  Fly   237 EL-LANPKVAQALASPASAHPKLLVA--------FSE----PLCES----TAQF-------EENG 277
            :| |.|   ..:..||.:|...|.|.        ||:    |..|.    |.||       ||..
Human  1282 QLHLPN---LNSQESPGTASVPLRVQNSWRRSQFFSQSVDSPSSEKSPVMTPQFKFWAWDPEEER 1343

  Fly   278 ALR---AQTREKLLGISKPALLSLVTHGIVYDKVLGILQEKKLNISRDPKLGPIAEFRKEYVNNP 339
            ..:   .|.:|:||...             |.|     ::.||....:.....:.|..:.|....
Human  1344 RRQEKWQQEQERLLQER-------------YQK-----EQDKLKEEWEKAQKEVEEEERRYYEEE 1390

  Fly   340 QFRAEINTICPQPPMTPIKSPPGTPFNSPLPLKNPVQIRMGAQMRQDT-PMRRVKFGGVSTIVYD 403
            :...|...:    |.|...|             :..|:...:.|.:.: .|.::..|       :
Human  1391 RKIIEDTVV----PFTVSSS-------------SADQLSTSSSMTEGSGTMNKIDLG-------N 1431

  Fly   404 CGLPANTDYDRDPVFAQILQAEPLKHAFQEARAGRAPSSVVISNIPAPVASLAELRGLNPATRAQ 468
            |     .|..:|         ...|.:||
Human  1432 C-----QDEKQD---------RRWKKSFQ------------------------------------ 1446

  Fly   469 LQSVGLDKNMLQSAVSNAPYYDRLFR--SLHDKGISHDQCHLLQPM-KQVHDWLLDDDQLLDEID 530
                |.|.::|.....:    |||..  ||.:..::|..    .|: |.||    :|.||
Human  1447 ----GDDSDLLLKTRES----DRLEEKGSLTEGALAHSG----NPVSKGVH----EDHQL----- 1490

  Fly   531 KVFADMANGCKDISYPKPSLGELPTSQSSDSGFHSKPPTPGYGSEDLTAGQGRFASIPGIEDMN- 594
                       |.....|..|..| ..:.|...:.:...|.:.|||:     :..::|..:.:|
Human  1491 -----------DTEAGAPHCGTNP-QLAQDPSQNQQTSNPTHSSEDV-----KPKTLPLDKSINH 1538

  Fly   595 --------------------MYPSCAGMPEQFQQLRLHGDEASGKNSTRTILCADCNQPIAMGEV 639
                                .:..|:..|.. |....:....|||.     ||:.|..|:..|..
Human  1539 QIESPSERRKKSPREHFQAGPFSPCSPTPPG-QSPNRYKRSISGKK-----LCSSCGLPLGKGAA 1597

  Fly   640 AVKADRAGKEIAWHPGCFKCITCRELLADLVYFFHQGQVFCGRDLAIRLKIPRCRACDELIFTKE 704
            .:...   ..:.:|..||:|..|:..|.|.|         .|.|:.||..:..|..|    :.:.
Human  1598 MIIET---LNLYFHIQCFRCGICKGQLGDAV---------SGTDVRIRNGLLNCNDC----YMRS 1646

  Fly   705 YTAAEEAT 712
            .:|.:..|
Human  1647 RSAGQPTT 1654

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tes	NP_611215.1	PET_testin	110..197	CDD:193604	19/100 (19%)
		LIM1_Testin_like	627..684	CDD:188726	13/56 (23%)
		LIM2_Testin_like	691..748	CDD:188727	4/22 (18%)
		LIM	755..810	CDD:413332
LIMCH1	XP_011511944.1	CH_LIMCH1	23..140	CDD:409127
		DUF4757	250..>311	CDD:464950
		DUF4757	813..962	CDD:464950
		GBP_C	<1340..1377	CDD:293879	10/54 (19%)
		LIM	1585..1642	CDD:214528	17/68 (25%)