Protein Alignment mthl4 and mthl9

DIOPT Version :10

• Sequence 1: NP_788394.1
• Gene: mthl4 / 36960
• FlyBaseID: FBgn0034219
• Length: 517
• Species: Drosophila melanogaster
• Sequence 2: NP_612029.1
• Gene: mthl9 / 38056
• FlyBaseID: FBgn0035131
• Length: 513
• Species: Drosophila melanogaster
• Alignment Length: 497
• Identity: 130/497 - (26%)
• Similarity: 236/497 - (47%)
• Gaps: 63/497 - (12%)

  Fly     3 ILLIAVLFLLMPKSNAEIPG----CDFFDTVDISKAPRFSNGSYLYEGLLIPAHLTAEYDYKLLA 63
            ::::.:::|.:...:.||..    |.:..||:|:...|..:|||.|.|:::|.||.|||.:|::
  Fly     5 LIILLIIWLSVGAKSVEIASINHPCAYAHTVNITDGLRMKDGSYSYAGVVVPPHLMAEYSFKVI- 68

  Fly    64 DDSKEKVASHVRGCACHLRPCIRFCCPQYQKMQKSKCYGDMSEDELNKHDPFVNVTLSDGSVVRR 128
            |..:.:...|:|||.|.|:|||.||||: ..:..:|.:......:: :....|.:|.::.:|.:.
  Fly    69 DGVEYRAKKHLRGCVCLLKPCISFCCPE-NLVFDAKHWNCTMPHQV-RESTHVELTYANRTVDQV 131

  Fly   129 HFKEDLIVQSDLAKPGCPRMYFLN--HELPGN--EFTLFENGSLLRHWDKVELSKREYCVQHLSF 189
            ..::..:|:::|   || |..|::  |:   |  ::.|||||:|.|  |....|..|||...|..
  Fly   132 RIRDRFVVRTEL---GC-RNKFVDKKHD---NFWQWDLFENGTLRR--DNRLWSTDEYCFSPLEH 187

  Fly   190 KDDSIRIAPHFCPLSSEHSRTWKTVAIVISLICIILTISVYLYVEKLRNL----HGKCFICYLAS 250
            ..:...:.|..|.......|.|  :..:.|:|.||:.|.:...:..:|:.    :|:..|.||.|
  Fly   188 NPEQWELTPLNCERFQTGYRVW--IYAICSIIAIIINIFILSLLGSVRDARKSHYGQLIIYYLLS 250

  Fly   251 LFLGYFFLVL----NVWKYSSGFCVTAGFLGYFSVMAAFFWLSVIGIHLRIKFSLASNCLHRLLP 311
            :.:||..||.    |..|.|...|...|||.||.:|.:|.:|::..:...:||.       :...
  Fly   251 MIVGYSLLVYLALKNPMKLSHVACRNIGFLAYFCIMLSFVFLAICSLDFLLKFK-------QKAV 308

  Fly   312 ENPFRAYNLYAWGIPLIMTAITYTADQVVKNEK-LRPRVGVGKN-CWIYTGDMTVMIYFYGPMLL 374
            .:..|..:|....:.:|......:..|..|..| .:|  |:|:: ||.......::||:|||:.|
  Fly   309 RSSVRRLSLALAVLAVIGLRFLVSLAQDSKLPKHFKP--GMGEDYCWFDVRTWGILIYYYGPIAL 371

  Fly   375 LIAFNIIMFVLSAIYIYNIKKNVKGLVHKQQTNQQINDQQMFAIFLRLFILMGLSWSFEILSFLL 439
            |:.|:|:..:.:...||.:..:.:.::..|....:.:.....|..:.:|.:    |..||:.:::
  Fly   372 LLIFSIVCCLKAYFSIYELPPDTQYILGTQLKIVKTHFYAFSAYIVGVFAV----WIREIVVYIM 432

  Fly   440 TKQQAWARALMVADYFNWSQGTIIFVL-FILKPSILKLIIAG 480
            .:         |.::|        |:: |.....||.|.|||
  Fly   433 AR---------VREHF--------FIIDFWSGICILGLAIAG 457

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl4	NP_788394.1	Methuselah_N	23..201	CDD:429053	57/181 (31%)
		7tmB3_Methuselah-like	205..477	CDD:410632	65/282 (23%)
		TM helix 1	207..232	CDD:410632	7/24 (29%)
		TM helix 2	241..263	CDD:410632	10/25 (40%)
		TM helix 3	271..298	CDD:410632	8/26 (31%)
		TM helix 4	315..335	CDD:410632	3/19 (16%)
		TM helix 5	361..390	CDD:410632	9/28 (32%)
		TM helix 6	411..438	CDD:410632	5/26 (19%)
		TM helix 7	446..471	CDD:410632	4/25 (16%)
mthl9	NP_612029.1	Methuselah_N	29..199	CDD:429053	57/181 (31%)
		7tmB3_Methuselah-like	232..473	CDD:410632	62/256 (24%)
		TM helix 2	241..263	CDD:410632	9/21 (43%)
		TM helix 3	275..302	CDD:410632	8/26 (31%)
		TM helix 4	314..334	CDD:410632	2/19 (11%)
		TM helix 5	358..387	CDD:410632	9/28 (32%)
		TM helix 6	404..431	CDD:410632	5/30 (17%)
		TM helix 7	440..465	CDD:410632	8/18 (44%)