Protein Alignment mthl4 and LOC1280992

DIOPT Version :10

• Sequence 1: NP_788394.1
• Gene: mthl4 / 36960
• FlyBaseID: FBgn0034219
• Length: 517
• Species: Drosophila melanogaster
• Sequence 2: XP_320866.3
• Gene: LOC1280992 / 1280992
• VectorBaseID: AGAMI1_010236
• Length: 682
• Species: Anopheles gambiae
• Alignment Length: 553
• Identity: 105/553 - (18%)
• Similarity: 183/553 - (33%)
• Gaps: 197/553 - (35%)

  Fly    11 LLMPKSNAEIPGCDFFDTVDISKAPRFSNGSYLYEGLLIPAHLTAEYDYKLLADDSKEKVASHVR 75
            |.||:...:..|....|.:..|             |...|...|.|       |||
Mosquito   154 LAMPEKEDDGLGTPLLDGLGAS-------------GSTAPPPTTVE-------DDS--------- 189

  Fly    76 GCACHLR------------PCIRFCCPQYQKM--QKSK------------------------CYG 102
             |..|.:            ..:|.|||..:.:  :.||                        |..
Mosquito   190 -CRGHEKLPTQPEYVSRDASIMRKCCPPGESLVSEHSKHVSCQKDAPSSYLPQPIVAQFYRDCIE 253

  Fly   103 DMSEDELNKHDPFVNVTLSDGSVVR--RHFKEDLIVQSDLAKPGCPRMYFLNHELPGNEFTLFEN 165
            |: |:||.....:.|...|:|.:|.  .|..:.|.|                          .:|
Mosquito   254 DL-EEELRLDVRYGNPCPSEGGMVSFGAHTNDTLYV--------------------------IQN 291

  Fly   166 GSLL-----RHWDKVELSKREYCVQHLSFKDDSIRIAPHFCPLSSE---------HSRTWKTVAI 216
            ||||     :.:|..:    .||:.:  .:.|...:| :.||  ||         ......|:.:
Mosquito   292 GSLLVIYGGKDYDVYD----TYCLDY--DRTDGALLA-YVCP--SEVRVMVDVVKGQLFLLTICL 347

  Fly   217 VISLICIILTISVYLYVEKLRNLHGKCF----ICYLASLFLGYFFLVLNVWK-YSSGFCVTAGFL 276
            ::::..:::|..:|:.|.||.:|||:..    :.:..:|.|..||...|..| ......|...:.
Mosquito   348 IVAIPALLVTALLYIIVPKLHDLHGRALAMNCVNFAIALLLECFFQYRNRGKRMLMDDMVLENYA 412

  Fly   277 GYFSVMAAFFWLSVIGIHLRIKFSLASNCLH-----------RLLPENP-FRAYNLYAWGIPLIM 329
            .|| ::|.||||.|         :..:||.|           ..|.:|. |..|..:|..|||
Mosquito   413 EYF-ILATFFWLLV---------NCGNNCFHAWYYVPRGKKANTLEDNQRFALYAAFAQLIPL-- 465

  Fly   330 TAITYTADQVVKNEKLRPRVGVGKNCWIYTGDMTVMIYFYGPMLLLIAFNIIMFVLSAIYIYNIK 394
                    .::.:..:.|           .|...:..|.:.|:.:.:....:..:::.:.:..:
Mosquito   466 --------WIILSYSMTP-----------AGTPAIKHYLFIPIGVTLGLGSLCLLVTLLGLTRL- 510

  Fly   395 KNVKGLVHKQQTNQQINDQQMF----------------AIFLR-----LFILMGLSWSFEILSFL 438
            ||.....|  |..|::.....:                .|::.     ||::||..|:...:::.
Mosquito   511 KNCYYTCH--QIRQRLVQSGQYEELCKYVPVCGRKVNKVIYMNKYTVPLFVVMGTIWTVMAVTYY 573

  Fly   439 LTKQQAWARALMVADYFNWSQGTIIFVLFILKP 471
            .|....     :..|.....||.::||:|:..|
Mosquito   574 ATYDLP-----IFYDILFGFQGILMFVIFVCMP 601

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl4	NP_788394.1	Methuselah_N	23..201	CDD:429053	39/222 (18%)
		7tmB3_Methuselah-like	205..477	CDD:410632	60/314 (19%)
		TM helix 1	207..232	CDD:410632	3/24 (13%)
		TM helix 2	241..263	CDD:410632	6/25 (24%)
		TM helix 3	271..298	CDD:410632	9/26 (35%)
		TM helix 4	315..335	CDD:410632	6/19 (32%)
		TM helix 5	361..390	CDD:410632	2/28 (7%)
		TM helix 6	411..438	CDD:410632	6/47 (13%)
		TM helix 7	446..471	CDD:410632	6/24 (25%)
LOC1280992	XP_320866.3	None