Protein Alignment cnk and BOI1

DIOPT Version :10

• Sequence 1: NP_725671.1
• Gene: cnk / 36952
• FlyBaseID: FBgn0286070
• Length: 1557
• Species: Drosophila melanogaster
• Sequence 2: NP_009468.1
• Gene: BOI1 / 852193
• SGDID: S000000181
• Length: 980
• Species: Saccharomyces cerevisiae
• Alignment Length: 877
• Identity: 170/877 - (19%)
• Similarity: 260/877 - (29%)
• Gaps: 306/877 - (34%)

  Fly   776 EVHSKPHAFKVYHTAKSFYFAAES----LDALNQWVDFLRQASLKVPPSTGSKGGGDAKDLYSEN 836
            |::|....|:::...::...|.:|    |||......|..||:..:|.:|.:      :|...:.
Yeast   272 EINSFGIRFQIFKEIRNIKSAIDSSSNKLDADYSTFAFENQAAQLMPAATVN------RDEIQQQ 330

  Fly   837 DSSGEECDALVIQNLSTPSPQGNKESMSMSMTLSGGTPPSSAPIKHERGYLDSFRKFTNTFKSSA 901
            .||  :|:.|       .|...:::|.|::..|.   .|||..:
Yeast   331 ISS--KCNKL-------SSESSDRKSSSVTTELQ---RPSSVVV--------------------- 362

  Fly   902 AKPSSDIPVPTEQYRSYRKVPGGSFGIQI------GANTPGYHDPAMPPTQIPPLVGPKLSRSSS 960
             .|:..:..|.||.....:||.......|      ....|.|..|..||..  |....:.:.:::
Yeast   363 -NPNFKLHDPAEQILDMTEVPNLFADKDIFESPGRAPKPPSYPSPVQPPQS--PSFNNRYTNNNA 424

  Fly   961 RSSVVSGTESAVSLSASILGPPAS--PAPTPTPTATPTSLQHQSSEES---------PSQSQSQS 1014
            |.                  ||.:  |.....||.....|...||..|         |:.:...|
Yeast   425 RF------------------PPQTTYPPKNKNPTVYSNGLIPNSSTSSDNSTGKFKFPAMNGHDS 471

  Fly  1015 PSSKSSLKKAPFNFLHASNPNLVEFDFHTSKTLLPKMS--VGNTLDHGHNIQGFVTLKDLMLRKQ 1077
            .|.|::|..|....::..|         |.:: ||.:|  ..|...|..|....|
Yeast   472 NSRKTTLTSATIPSINTVN---------TDES-LPAISNISSNATSHHPNRNSVV---------- 516

  Fly  1078 EEEAQEMYNNRVHLGVEKHKHARTESTAS-------------QQSAMSSSVTKPLEKLPKIQSVS 1129
                   |||          |.||||.:|             .:|:.....||...|..:....|
Yeast   517 -------YNN----------HKRTESGSSFVDLFNRISMLSPVKSSFDEEETKQPSKASRAVFDS 564

  Fly  1130 LPKTPDYEIS--------------------FKPDDESIKRTRTKEGQKLRDFGYELICGDEPSTS 1174
            ..:...|..|                    |....:|...:.||:...:          |....:
Yeast   565 ARRKSSYGHSRDASLSEMKKHRRNSSILSFFSSKSQSNPTSPTKQTFTI----------DPAKMT 619

  Fly  1175 SISRQEHHHHHHHHQHHLQHVQQQQ-------------------QLQHQQT-------------- 1206
            |.||.:.:.:.|.......|.::..                   .|.|.:|
Yeast   620 SHSRSQSNSYSHARSQSYSHSRKHSLVTSPLKTSLSPINSKSNIALAHSETPTSSNNKEAVSQPS 684

  Fly  1207 QQQHSSKAKHFLRSQQLQLSSFLHKNSSGGSGKSSGSGADQKKSKGK--SSGDRRFPFSKHSTGS 1269
            :.:|..|.||        .|...||||      ||..|:.::|||.|  ||....|..||....|
Yeast   685 EGKHKHKHKH--------KSKHKHKNS------SSKDGSSEEKSKKKLFSSTKESFVGSKEFKRS 735

  Fly  1270 AGSGCGPGHAMTMTLPLNKKSKSNHALDGAVGNGVTIIGSGSSIKKSQT--YNQDLRDKIVGTKY 1332
            ...             |.:||..:             |...|:.||.||  :.:.:|
Yeast   736 PSE-------------LTQKSTKS-------------ILPRSNAKKQQTSAFTEGIR-------- 766

  Fly  1333 DAHRKNSAPIPIFSKLSISGGTPAKPSKENRFLGSPLLHRT---LFGHHHHQQQ---------AV 1385
            ....|.|......|......||.|..:.:.||.   .||.|   .|.:.:.:::         .|
Yeast   767 SITAKESMQTADCSGWMSKKGTGAMGTWKQRFF---TLHGTRLSYFTNTNDEKERGLIDITAHRV 828

  Fly  1386 TPPSSADPDCDQEIFSQITLPTHNQAGYRSYRGPGILTTSTTNLCSSEGLQPPLPPA------PP 1444
            .|.|..|        ..|:|       |.:..|.|       ..|..  |.||.|.:      ..
Yeast   829 LPASDDD--------RLISL-------YAASLGKG-------KYCFK--LVPPQPGSKKGLTFTE 869

  Fly  1445 PPVNTSRQREEEQAEATISE-CAATPKVSSSGSVDSKAATPDYPNMECPPVFEPEIYSLSDTSLS 1508
            |.|:......:.:.:|.:|. ..||..:.:|..|.|..|||..|            .|.:.|.|.
Yeast   870 PRVHYFAVENKSEMKAWLSAIIKATIDIDTSVPVISSYATPTIP------------LSKAQTLLE 922

  Fly  1509 RIVMRTPSSSGATSATASTTTTNNNNNNNNTN 1540
            ...::|................::..|..|:|
Yeast   923 EARLQTQLRDAEEEEGRDQFGWDDTQNKRNSN 954

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cnk	NP_725671.1	SAM_CNK1,2,3-suppressor	6..74	CDD:188910
		CRIC_ras_sig	82..165	CDD:463138
		PDZ_CNK1_2_3-like	203..283	CDD:467230
		PH_CNK_insect-like	720..810	CDD:270135	8/37 (22%)
BOI1	NP_009468.1	SH3_BOI	17..71	CDD:212819
		SAM_superfamily	226..290	CDD:472832	3/17 (18%)
		PH_Boi	778..894	CDD:270126	28/142 (20%)