Protein Alignment cnk and si:ch211-26b3.4

DIOPT Version :10

• Sequence 1: NP_725671.1
• Gene: cnk / 36952
• FlyBaseID: FBgn0286070
• Length: 1557
• Species: Drosophila melanogaster
• Sequence 2: XP_021327272.1
• Gene: si:ch211-26b3.4 / 568768
• ZFINID: ZDB-GENE-081104-60
• Length: 1031
• Species: Danio rerio
• Alignment Length: 1279
• Identity: 307/1279 - (24%)
• Similarity: 474/1279 - (37%)
• Gaps: 396/1279 - (30%)

  Fly     6 IAEWTPDQVTDWIKGLDESMKGYLYEFSKQEIGGRALLNIRPYELENLGMLRIGHQEIVLEAVEN 70
            |::|:|.||.||:||||:.:..|:..|.:::|.|..||:|...|||.||:.||||||::||||:.
Zfish     8 ISKWSPKQVLDWMKGLDDCLLQYMRTFEREQITGEQLLHITHQELEELGVTRIGHQELILEAVDL 72

  Fly    71 LRNFHYHLKNDNLQFMALHVATAAKNLHRELA---RNHAESTKIDTRILHDITRTIATL----KP 128
            |...:|.|:.:||:.::..:..:||||...:.   |......::..|:.:|...::..|    |.
Zfish    73 LCALNYGLETENLRTLSHKLNASAKNLQNFITGRRRGGHYDGRVSRRLPNDFLTSVVDLIGAAKN 137

  Fly   129 LVGSLERTPFRKQEMYREYCGNVLKCGLELATIAHRDRFALQPVPAIRQSAERLENLANFVIQDI 193
            |:..|:|:||.....|.....|:::..|||.||..:|....:....|....:.|..:...:|...
Zfish   138 LLAWLDRSPFVSVSEYSVLKNNIVQLCLELTTIVQQDCTVYETENKILHVCKTLSGICEHIISLS 202

  Fly   194 SDPMVLQPASLNLVTLKK-RESE-LGFNIESSYNGIHRVTDIKYNSPAHNSGKIEDGDEIVQINY 256
            ||.:|.|.|.|.:|.|.. ..|| ||..|:|:|:|:|.:|....||||....||..|||::|:|:
Zfish   203 SDSLVSQSAHLEVVHLTNVMPSEGLGMYIKSTYDGLHVITGTTENSPADQCKKIHAGDEVIQVNH 267

  Fly   257 QTVVGWQHRTVLEHLREALPDVVLTVKKRPKHTKMFGQIYMQPYRLPSKKRNMAARWAAQMPSPR 321
            |||||||.:.::..|||....|:||:||||::|  .|.       .|:..:|  |||
Zfish   268 QTVVGWQLKNLVNCLREDPSGVILTLKKRPQNT--LGS-------TPALLKN--ARW-------- 313

  Fly   322 AAFLTLDTEQLATGGTGSAVPDPSKSLSSEKREVLTKANPVSSASDSDSSCSDIPTPTDPKLAAR 386
                                                  .|::....|.|.||..|||
Zfish   314 --------------------------------------KPLALQPLSTSPCSGSPTP-------- 332

  Fly   387 EIRLYYPKPRALLQRRNTICGCEYLSLKNSDLVVPSWHERKPGIGSPTNCDPGSPSIRDKSISFG 451
                    |..|        |...||               ||:.:     ||...:...|..:|
Zfish   333 --------PSTL--------GSVGLS---------------PGVDT-----PGGHDVFILSPVYG 361

  Fly   452 YGLEMAARPTTCIGIAGDTSTDKARRMFHEARKLKQLTEDSQREFLVDRYKPGVSKVVRFDAKED 516
            :..|...|..  .|:.|..|                               ||
Zfish   362 HREEDLDRGG--FGVFGSDS-------------------------------PG------------ 381

  Fly   517 YVMKNEKFICNVENTILETFEPIPFADEGDEDALETLRNCKTENAEELLEAINLATKGQDLPLAE 581
            |.::.|        .:...:.|:...:.|....|.  |..:|....:|.: :::.|:.    |||
Zfish   382 YYVEQE--------VLGGQYFPLLEEESGRNTGLR--RRDRTPTHSDLRQ-VSMGTEW----LAE 431

  Fly   582 AINMPLLQQGRRGRLDKSHSTPAYDNSG------EESDTPPAIEPRKEFLLVTPPAPPPRPRKQR 640
            .....:.::|.|   |...|...:.:..      ||::.......|:.......|:.|..|
Zfish   432 PQESGVYKRGSR---DSDSSLLRFLSDDRILLIQEEAEFSQRDTSRRSRKKSRNPSSPSFP---- 489

  Fly   641 EMTPPAVPPP------PPKPASMQPASSITSISIPVPVPVPAAVDPSEISELHTPSKS------- 692
             ::|..:.||      ||:             .:|.|||     |.:.:...|..:.:
Zfish   490 -ISPSMLAPPVRLDTGPPE-------------GLPFPVP-----DSNTMPHYHRAADTLRADADR 535

  Fly   693 -----------------------RTLTLKK-KHSL-MAKRRNTNLKLLGTGDIQGHLYRRKKNHR 732
                                   ||...|| |.|| .|.||....|.||.||.:|.|: :||:..
Zfish   536 YASSGLDRQAGASMRKSVHYASLRTKPKKKSKGSLSSASRRRIACKDLGHGDCEGWLW-KKKDAT 599

  Fly   733 G--VTYWARIYFVMLDTILYGFRSKQSTSASLVIFLPGFTVSLAKEVHSKPHAFKVYH-TAKSFY 794
            |  ...|.:.:||:.|:.||.:.::....|...|.||.|.:..|.|...| ||||..| ..|||:
Zfish   600 GYFTQKWKKYWFVLKDSNLYWYTNQNDEKAEGFISLPEFRIDRAIECRRK-HAFKACHPKIKSFF 663

  Fly   795 FAAESLDALNQWVDFLRQASLKVPPSTGSKGGGDA-----KDLYSENDSSGEECDALVIQNLSTP 854
            ||.:.|:.:|:|::.|..|::...|.       |.     :|.:||:|.  :|.|.
Zfish   664 FATDHLEEMNRWMNRLGLAAIGYTPD-------DPVPRPDEDYWSESDQ--DEVDG--------- 710

  Fly   855 SPQGNKESMSMSMTLS-------GGTPPSSAPIKHERGYLDSFRKFT--NTFKSSAAKPS-SDIP 909
                       ||||.       ..|..|::|...        |.|:  :||..|:|:.| |...
Zfish   711 -----------SMTLKQEATYHHNPTATSTSPFPE--------RHFSSGSTFSHSSAEESHSSCR 756

  Fly   910 VPTEQYRSYRKVPGGSFGIQIGANTPGYHDPAMPPTQIPPLVGPKLSRSSSRSSVVSGTESAVSL 974
            ....:.||::.:      |:....:.|.|.......:.|.|:.|...|.:             :|
Zfish   757 SSHRERRSWQDL------IETPLTSTGLHYLQTAEEEEPGLLSPDQLRQA-------------TL 802

  Fly   975 SASILGPPASPAPTPTPTATPTSLQH----QSSEESPSQSQSQSPSSKSSLKKAPFNFLHASNPN 1035
            .|....|.....|.|...:..:..:|    |.|:..|....:....|..|.:.
Zfish   803 PAQRRRPLERDGPFPLTDSEESRPRHHTHKQRSQSLPRHRDTHGGHSHRSTRT------------ 855

  Fly  1036 LVEFDFHTSKTLLPKMSVGNTLDHGHNIQGFVTLKDLMLRKQEEEAQEMYNNRVHLGVEKHKHAR 1100
                ..||..||.|:       .|.|                ||:.:|          |:.||.|
Zfish   856 ----HMHTHGTLRPR-------THLH----------------EEDEEE----------EEEKHVR 883

  Fly  1101 TESTASQQS-AMSSSVTKPLEKLPK-IQSVSL-------PKT-PDYEISF--KPDD----ESIKR 1149
            ..|:...:| ..:|..|..|::|.| ::..||       |.| .::..||  :.:|    |.:.|
Zfish   884 KASSRRPESDEKASDGTDGLQELYKSLEQASLSAFGQQRPSTKQEFRRSFIKRSNDPATNERLHR 948

  Fly  1150 TR-------TKEGQKLRDFGYELICGDEPSTSSISRQEHHHHHH 1186
            .|       .|||    |........|:|..:|...:|....:|
Zfish   949 IRVLRSTLKAKEG----DLSIISQVLDDPCLTSRKFREWKQRNH 988

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cnk	NP_725671.1	SAM_CNK1,2,3-suppressor	6..74	CDD:188910	34/67 (51%)
		CRIC_ras_sig	82..165	CDD:463138	23/89 (26%)
		PDZ_CNK1_2_3-like	203..283	CDD:467230	37/81 (46%)
		PH_CNK_insect-like	720..810	CDD:270135	32/92 (35%)
si:ch211-26b3.4	XP_021327272.1	SAM_CNK1,2,3-suppressor	8..76	CDD:188910	34/67 (51%)
		CRIC_ras_sig	84..176	CDD:463138	24/91 (26%)
		PDZ_CNK1_2_3-like	214..294	CDD:467230	36/79 (46%)
		CNK2_3_dom	352..>479	CDD:461979	28/189 (15%)
		PH_CNK_mammalian-like	575..686	CDD:269962	41/112 (37%)