Protein Alignment cnk and cnksr2a

DIOPT Version :10

• Sequence 1: NP_725671.1
• Gene: cnk / 36952
• FlyBaseID: FBgn0286070
• Length: 1557
• Species: Drosophila melanogaster
• Sequence 2: XP_068073311.1
• Gene: cnksr2a / 561623
• ZFINID: ZDB-GENE-060228-5
• Length: 1040
• Species: Danio rerio
• Alignment Length: 1216
• Identity: 289/1216 - (23%)
• Similarity: 445/1216 - (36%)
• Gaps: 400/1216 - (32%)

  Fly     6 IAEWTPDQVTDWIKGLDESMKGYLYEFSKQEIGGRALLNIRPYELENLGMLRIGHQEIVLEAVEN 70
            :::|:|.||.||:||||:.::.|:..|.::::||..||.|...|||:||:.||||||::||||:.
Zfish     8 VSKWSPSQVVDWMKGLDDCLQQYIKNFEREKVGGDQLLRITHQELEDLGVSRIGHQELILEAVDL 72

  Fly    71 LRNFHYHLKNDNLQFMALHVATAAKNLHRELA----RNHAE---STKIDTRILHDITRTIATLKP 128
            |...:|.|:.:||:.::..:..:||||...:.    ..|.:   :.|:....|..:...||..|.
Zfish    73 LCALNYGLETENLKTLSHKLNASAKNLQNFITGRRRSGHYDGRTTRKLPNDFLTSVVDLIAAAKS 137

  Fly   129 LVGSLE------RTPFRKQEMYREYCGNVLKCGLELATIAHRDRFALQPVPAIRQSAERLENLAN 187
            |:..|:      |:||.....|.....||::..|||.||..:|....:....|....:.|..:.:
Zfish   138 LLAWLDRCYFFCRSPFAAVTDYSVTRNNVIQLCLELTTIVQQDCTVYETENKILHVCKTLSGVCD 202

  Fly   188 FVIQDISDPMVLQPASLNLVTLK--KRESELGFNIESSYNGIHRVTDIKYNSPAHNSGKIEDGDE 250
            .:|...|||:|.|.|.|.:|.|.  |....||..|:|:|:|:|.:|.....|||....||..|||
Zfish   203 HIISLSSDPLVSQSAHLEVVQLANIKPTEGLGMYIKSTYDGLHVITGTTEGSPADRCKKIHAGDE 267

  Fly   251 IVQINYQTVVGWQHRTVLEHLREALPDVVLTVKKRPKHTKMFGQIYMQPYRLPSKKRNMAARW-- 313
            ::|:|:|||||||.:.::..||.....|.||:||||:.|..         ..|:..:||  ||
Zfish   268 VIQVNHQTVVGWQLKNLVSSLRGDPAGVTLTLKKRPQSTLT---------SAPALLKNM--RWKP 321

  Fly   314 -AAQMPSPRAAFLTLDTEQLATGGTGSAVPDPSKSLSSEKREVLTKANPVSSASDSDSSC-SDI- 375
             |.|.|                     .||....|.|:      |..:.:|:.|..|||. .|:
Zfish   322 LALQQP---------------------VVPRSPTSSSA------TPTSTISTPSKRDSSALQDLY 359

  Fly   376 --PTPTDPKLAAREIRLYYPKPRALLQRRNTICGCEYLSLKNSDLVVPSWHERKPGIGSPTNC-- 436
              |.|::|         |.|.......||                      :.|.||.|.:..
Zfish   360 IPPPPSEP---------YTPSGIHTNVRR----------------------DEKGGIQSESGVPV 393

  Fly   437 -----DPGS----------PSIRDKSISFGYGLEMAARPTTCIGIAGDTSTDKARRMFHEARKLK 486
                 .|.|          |.:.::::.:.|..:.:..|||            :||
Zfish   394 AKGSESPNSFLDQEYRRRFPLVEEEAVLYCYEYDPSHGPTT------------SRR--------- 437

  Fly   487 QLTEDSQREFLVDRYKPGVSKVVRFDAKEDYVMKNEKFICNVENTILETFEPIPFADEGDEDALE 551
                ||...:  .|.:| :|..|.::...||                             ||...
Zfish   438 ----DSTPTY--GRLRP-ISMPVEYNWVPDY-----------------------------EDPAR 466

  Fly   552 TLRNCKTENAEELLEAINLATKGQDLPLAEAINMPLLQQGRRGRLDKSHSTPAYDNSGEESDTP- 615
            ..|:.:.||:  ||..:: ..|..||    |........|:||:           ...|:|.:|
Zfish   467 VKRDGRRENS--LLRYVS-DEKAADL----AGRSMKRDTGKRGK-----------KKSEKSGSPT 513

  Fly   616 -----PAIEPRKEFLLVTPPAPPPRPRKQREMTPPAVPPPPPKPASMQPASSITSISIPVPVPVP 675
                 |.::  .|.|            :|..|..|
Zfish   514 HYSLLPTLQ--MEVL------------RQESMNTP------------------------------ 534

  Fly   676 AAVDPSEISELHTPSKSRTLTLKKKHSLMA-----KRRNTNLKLLGTGDIQGHLYRRKKNHRGVT 735
               :|...|..||...|..|:..||.|..|     .:|..:.|.||.||.:|.|:::|.   ..:
Zfish   535 ---NPDSTSLYHTFQGSSLLSKTKKKSKAAPLSSISKRRISCKDLGRGDCEGWLWKKKD---AKS 593

  Fly   736 Y----WARIYFVMLDTILYGFRSKQSTSASLVIFLPGFTVSLAKEVHSKPHAFKVYH-TAKSFYF 795
            |    |.:.:||:.|..||.:.:::...|...:.||.|.:..|.|...| :|||..| ..|||||
Zfish   594 YFSQKWKKYWFVLKDACLYWYMNEEDEKAEGFVSLPEFKIDRASECRKK-YAFKACHPKIKSFYF 657

  Fly   796 AAESLDALNQWVDFLRQASLKVPPSTGSKGGGDAK---------DLYSENDSSGEECDALVIQNL 851
            ||:.:|.:|:|:..|..|:           .|.|:         |.:||:|....|
Zfish   658 AADGVDDMNRWLSRLNMAA-----------AGYAERERIRQEHADYWSESDHEDNE--------- 702

  Fly   852 STPSPQGNKESMSMSMTLSGGTPPSSAPIKHERGYLDSFRKFTNTFKSSAAKPSSDIPVPTEQYR 916
             |||                 ||...:|                             |.|.:.|
Zfish   703 -TPS-----------------TPKQDSP-----------------------------PPPYDTY- 719

  Fly   917 SYRKVPGGSFGIQIGANTPGYHDPAMPPTQI---PPLVGPKLSR------SSSRSSVVSGTESAV 972
                                   |..|..|:   .|.:.||..|      |.||||.........
Zfish   720 -----------------------PRPPSNQVSCASPYLEPKHGRLSSTETSQSRSSHEEYRSEPQ 761

  Fly   973 SLSASILGPPASPA-----------PTPTPTATPTSLQHQSSEE----------SPS-QSQSQSP 1015
            ..|:|..|.||..:           .||..::....||....|:          ||. :.||..|
Zfish   762 GGSSSGGGSPARKSASQRRSWQDLIETPLTSSGLHYLQTLPLEDAVFCEPGAGLSPEYRRQSTLP 826

  Fly  1016 SSKSSLKK--APFNFLHASNPNLVEFDFHTSKTLLPKMSVGN----TLDHGHNIQGFVTLKDLML 1074
            :.::.::.  .||..|..            .:...|..:||.    ||.....:...:|....|.
Zfish   827 AQRTLMQDHYGPFPMLQG------------ERLRDPVNAVGKPRSFTLPRDSGLHALLTPSASMA 879

  Fly  1075 RKQEEEAQEM-YNNRVHLGVEKHKHARTESTASQQSAMSSSVTKPL 1119
            .:::...:|: .:.|::.|.|:....:|:|......|:..:...|:
Zfish   880 DQRDPNRRELSRSQRINNGGEQDYQGQTDSLGDLYRALERARLTPI 925

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cnk	NP_725671.1	SAM_CNK1,2,3-suppressor	6..74	CDD:188910	33/67 (49%)
		CRIC_ras_sig	82..165	CDD:463138	25/95 (26%)
		PDZ_CNK1_2_3-like	203..283	CDD:467230	34/81 (42%)
		PH_CNK_insect-like	720..810	CDD:270135	31/94 (33%)
cnksr2a	XP_068073311.1	SAM_CNK1,2,3-suppressor	8..76	CDD:188910	33/67 (49%)
		CRIC_ras_sig	84..182	CDD:463138	26/97 (27%)
		PDZ_CNK1_2_3-like	220..300	CDD:467230	33/79 (42%)
		CNK2_3_dom	347..524	CDD:461979	51/284 (18%)
		PH_CNK_mammalian-like	567..680	CDD:269962	40/127 (31%)