DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cnk and cnksr2a

DIOPT Version :9

Sequence 1:	NP_001286524.1	Gene:	cnk / 36952	FlyBaseID:	FBgn0286070	Length:	1557	Species:	Drosophila melanogaster
Sequence 2:	XP_021326010.1	Gene:	cnksr2a / 561623	ZFINID:	ZDB-GENE-060228-5	Length:	1034	Species:	Danio rerio

Alignment Length:	1210	Identity:	289/1210 - (23%)
Similarity:	445/1210 - (36%)	Gaps:	394/1210 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IAEWTPDQVTDWIKGLDESMKGYLYEFSKQEIGGRALLNIRPYELENLGMLRIGHQEIVLEAVEN 70
            :::|:|.||.||:||||:.::.|:..|.::::||..||.|...|||:||:.||||||::||||:.
Zfish     8 VSKWSPSQVVDWMKGLDDCLQQYIKNFEREKVGGDQLLRITHQELEDLGVSRIGHQELILEAVDL 72

  Fly    71 LRNFHYHLKNDNLQFMALHVATAAKNLHRELA----RNHAE---STKIDTRILHDITRTIATLKP 128
            |...:|.|:.:||:.::..:..:||||...:.    ..|.:   :.|:....|..:...||..|.
Zfish    73 LCALNYGLETENLKTLSHKLNASAKNLQNFITGRRRSGHYDGRTTRKLPNDFLTSVVDLIAAAKS 137

  Fly   129 LVGSLERTPFRKQEMYREYCGNVLKCGLELATIAHRDRFALQPVPAIRQSAERLENLANFVIQDI 193
            |:..|:|:||.....|.....||::..|||.||..:|....:....|....:.|..:.:.:|...
Zfish   138 LLAWLDRSPFAAVTDYSVTRNNVIQLCLELTTIVQQDCTVYETENKILHVCKTLSGVCDHIISLS 202

  Fly   194 SDPMVLQPASLNLVTLK--KRESELGFNIESSYNGIHRVTDIKYNSPAHNSGKIEDGDEIVQINY 256
            |||:|.|.|.|.:|.|.  |....||..|:|:|:|:|.:|.....|||....||..|||::|:|:
Zfish   203 SDPLVSQSAHLEVVQLANIKPTEGLGMYIKSTYDGLHVITGTTEGSPADRCKKIHAGDEVIQVNH 267

  Fly   257 QTVVGWQHRTVLEHLREALPDVVLTVKKRPKHTKMFGQIYMQPYRLPSKKRNMAARW---AAQMP 318
            |||||||.:.::..||.....|.||:||||:.|..         ..|:..:||  ||   |.|.|
Zfish   268 QTVVGWQLKNLVSSLRGDPAGVTLTLKKRPQSTLT---------SAPALLKNM--RWKPLALQQP 321

  Fly   319 SPRAAFLTLDTEQLATGGTGSAVPDPSKSLSSEKREVLTKANPVSSASDSDSSC-SDI---PTPT 379
                                 .||....|.|:      |..:.:|:.|..|||. .|:   |.|:
Zfish   322 ---------------------VVPRSPTSSSA------TPTSTISTPSKRDSSALQDLYIPPPPS 359

  Fly   380 DPKLAAREIRLYYPKPRALLQRRNTICGCEYLSLKNSDLVVPSWHERKPGIGSPTNC-------D 437
            :|         |.|.......||                      :.|.||.|.:..       .
Zfish   360 EP---------YTPSGIHTNVRR----------------------DEKGGIQSESGVPVAKGSES 393

  Fly   438 PGS----------PSIRDKSISFGYGLEMAARPTTCIGIAGDTSTDKARRMFHEARKLKQLTEDS 492
            |.|          |.:.::::.:.|..:.:..|||            :||             ||
Zfish   394 PNSFLDQEYRRRFPLVEEEAVLYCYEYDPSHGPTT------------SRR-------------DS 433

  Fly   493 QREFLVDRYKPGVSKVVRFDAKEDYVMKNEKFICNVENTILETFEPIPFADEGDEDALETLRNCK 557
            ...:  .|.:| :|..|.::...||                             ||.....|:.:
Zfish   434 TPTY--GRLRP-ISMPVEYNWVPDY-----------------------------EDPARVKRDGR 466

  Fly   558 TENAEELLEAINLATKGQDLPLAEAINMPLLQQGRRGRLDKSHSTPAYDNSGEESDTP------P 616
            .||:  ||..:: ..|..||    |........|:||:           ...|:|.:|      |
Zfish   467 RENS--LLRYVS-DEKAADL----AGRSMKRDTGKRGK-----------KKSEKSGSPTHYSLLP 513

  Fly   617 AIEPRKEFLLVTPPAPPPRPRKQREMTPPAVPPPPPKPASMQPASSITSISIPVPVPVPAAVDPS 681
            .::  .|.|            :|..|..|                                 :|.
Zfish   514 TLQ--MEVL------------RQESMNTP---------------------------------NPD 531

  Fly   682 EISELHTPSKSRTLTLKKKHSLMA-----KRRNTNLKLLGTGDIQGHLYRRKKNHRGVTY----W 737
            ..|..||...|..|:..||.|..|     .:|..:.|.||.||.:|.|:::|.   ..:|    |
Zfish   532 STSLYHTFQGSSLLSKTKKKSKAAPLSSISKRRISCKDLGRGDCEGWLWKKKD---AKSYFSQKW 593

  Fly   738 ARIYFVMLDTILYGFRSKQSTSASLVIFLPGFTVSLAKEVHSKPHAFKVYH-TAKSFYFAAESLD 801
            .:.:||:.|..||.:.:::...|...:.||.|.:..|.|...| :|||..| ..|||||||:.:|
Zfish   594 KKYWFVLKDACLYWYMNEEDEKAEGFVSLPEFKIDRASECRKK-YAFKACHPKIKSFYFAADGVD 657

  Fly   802 ALNQWVDFLRQASLKVPPSTGSKGGGDAK---------DLYSENDSSGEECDALVIQNLSTPSPQ 857
            .:|:|:..|..|:           .|.|:         |.:||:|....|          |||
Zfish   658 DMNRWLSRLNMAA-----------AGYAERERIRQEHADYWSESDHEDNE----------TPS-- 699

  Fly   858 GNKESMSMSMTLSGGTPPSSAPIKHERGYLDSFRKFTNTFKSSAAKPSSDIPVPTEQYRSYRKVP 922
                           ||...:|                             |.|.:.|
Zfish   700 ---------------TPKQDSP-----------------------------PPPYDTY------- 713

  Fly   923 GGSFGIQIGANTPGYHDPAMPPTQI---PPLVGPKLSR------SSSRSSVVSGTESAVSLSASI 978
                             |..|..|:   .|.:.||..|      |.||||...........|:|.
Zfish   714 -----------------PRPPSNQVSCASPYLEPKHGRLSSTETSQSRSSHEEYRSEPQGGSSSG 761

  Fly   979 LGPPASPA-----------PTPTPTATPTSLQHQSSEE----------SPS-QSQSQSPSSKSSL 1021
            .|.||..:           .||..::....||....|:          ||. :.||..|:.::.:
Zfish   762 GGSPARKSASQRRSWQDLIETPLTSSGLHYLQTLPLEDAVFCEPGAGLSPEYRRQSTLPAQRTLM 826

  Fly  1022 KK--APFNFLHASNPNLVEFDFHTSKTLLPKMSVGN----TLDHGHNIQGFVTLKDLMLRKQEEE 1080
            :.  .||..|..            .:...|..:||.    ||.....:...:|....|..:::..
Zfish   827 QDHYGPFPMLQG------------ERLRDPVNAVGKPRSFTLPRDSGLHALLTPSASMADQRDPN 879

  Fly  1081 AQEM-YNNRVHLGVEKHKHARTESTASQQSAMSSSVTKPL 1119
            .:|: .:.|::.|.|:....:|:|......|:..:...|:
Zfish   880 RRELSRSQRINNGGEQDYQGQTDSLGDLYRALERARLTPI 919

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cnk	NP_001286524.1	SAM_CNK1,2,3-suppressor	6..74	CDD:188910	33/67 (49%)
		SAM	7..74	CDD:197735	33/66 (50%)
		CRIC_ras_sig	82..165	CDD:287501	25/89 (28%)
		PDZ_signaling	206..283	CDD:238492	33/78 (42%)
		PH	720..814	CDD:278594	32/98 (33%)
		PH_CNK_insect-like	720..810	CDD:270135	31/94 (33%)
cnksr2a	XP_021326010.1	SAM_CNK1,2,3-suppressor	8..76	CDD:188910	33/67 (49%)
		CRIC_ras_sig	84..176	CDD:313706	26/91 (29%)
		PDZ	225..295	CDD:320768	30/69 (43%)
		DUF1170	342..515	CDD:310926	51/278 (18%)
		PH_CNK_mammalian-like	561..674	CDD:269962	40/127 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594407
Domainoid	1	1.000	77	1.000	Domainoid score	I8761
eggNOG	1	0.900	-	-		E1_KOG1738
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	266	1.000	Inparanoid score	I3025
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1121556at2759
OrthoFinder	1	1.000	-	-		FOG0001221
OrthoInspector	1	1.000	-	-		otm25178
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12844
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3250
SonicParanoid	1	1.000	-	-		X1572
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.890