Protein Alignment cnk and cnksr2b

DIOPT Version :10

• Sequence 1: NP_725671.1
• Gene: cnk / 36952
• FlyBaseID: FBgn0286070
• Length: 1557
• Species: Drosophila melanogaster
• Sequence 2: XP_009293705.1
• Gene: cnksr2b / 558834
• ZFINID: ZDB-GENE-030131-8048
• Length: 969
• Species: Danio rerio
• Alignment Length: 1175
• Identity: 279/1175 - (23%)
• Similarity: 434/1175 - (36%)
• Gaps: 325/1175 - (27%)

  Fly     6 IAEWTPDQVTDWIKGLDESMKGYLYEFSKQEIGGRALLNIRPYELENLGMLRIGHQEIVLEAVEN 70
            ::.|:..||.||:||||:.::.|:..|.::::||..||.|...|||:||:.||||||::||||:.
Zfish     8 VSRWSTSQVVDWMKGLDDCLQQYIKNFEQEKVGGEQLLRITHQELEDLGVSRIGHQELILEAVDL 72

  Fly    71 LRNFHYHLKNDNLQFMALHVATAAKNLHRELA----RNHAE---STKIDTRILHDITRTIATLKP 128
            |...:|.|:.:||:.:...:..:||||...:.    ..|.:   :.|:....|..:...||..|.
Zfish    73 LCALNYGLETENLKTLTHKLNASAKNLQNFITGRRRGGHYDGRATRKLPNDFLTSVVDLIAAAKS 137

  Fly   129 LVGSLE------RTPFRKQEMYREYCGNVLKCGLELATIAHRDRFALQPVPAIRQSAERLENLAN 187
            |:..|:      |:||.....|.....||::..|||.||..:|....:....|....:.|..:.:
Zfish   138 LLAWLDRCYFFIRSPFAAVADYSMTRNNVIQLCLELTTIVQQDGTVYETENKILHVCKTLSGVCD 202

  Fly   188 FVIQDISDPMVLQPASLNLVTLKK-RESE-LGFNIESSYNGIHRVTDIKYNSPAHNSGKIEDGDE 250
            .:|...|||||.|.|.|.:|.|.. |.:| ||..|:|:|:|:|.:|.....|.|....||..|||
Zfish   203 HIIALSSDPMVSQAAHLEVVQLDNIRSTEGLGMYIKSTYDGLHVITGTTEGSLADRCKKIHAGDE 267

  Fly   251 IVQINYQTVVGWQHRTVLEHLREALPDVVLTVKKRPKHTKMFGQIYMQPYRLPSKKRNMAARW-- 313
            ::|:|:|||||||.:.::..||.....|.||:||||:.|..         ..|:..:||  ||
Zfish   268 VIQVNHQTVVGWQLKNLVNSLRSNPAGVTLTLKKRPQSTLT---------SAPALLKNM--RWKP 321

  Fly   314 -AAQ---MPSPRAAFLTLDTEQLATGGTGSAVPDPSKSLSSEKREVLTKANPVSSASDSDSSCS- 373
             |.|   .|||                 .|:|..||.:||:..|.               .||:
Zfish   322 LALQPIIPPSP-----------------SSSVATPSSTLSTPSRR---------------DSCAL 354

  Fly   374 -DI---PTPTDPKLAAREIRLYYPKPRALLQRRNTICGCEYLSLKNSDLVVPSWHERKPGIGSPT 434
             |:   |.|.:|         |.|:...    .|....|:. :.|.||         .|......
Zfish   355 QDLYIPPPPDEP---------YTPRDDV----GNLTSNCQQ-AAKGSD---------SPNSFLDQ 396

  Fly   435 NCDPGSPSIRDKSISFGYGLEMAARPTTCIGIAGDTSTDKARRMFHEARKLKQLTEDSQREFLVD 499
            .|....|.:.:.::.:.|..:....|            ...||             ||...:  .
Zfish   397 ECRRRFPLLDEDAVLYCYEYDQTQGP------------PPVRR-------------DSTPTY--G 434

  Fly   500 RYKPGVSKVVRFDAKEDYVMKNEKFICNVENTILETFEPIPFADEGDEDALETLRNCKTENAEEL 564
            |.:| :|..|.::...||                             ||..:..:..:.||:
Zfish   435 RLRP-ISMPVEYNWVGDY-----------------------------EDPAKLKKEIRRENS--- 466

  Fly   565 LEAINLATKGQDLPLAEAINMPLLQQGRRGRLDKSHSTPAYDNSGEESDTPPAIEPRKEFLLVTP 629
                          |...::....::...||.....|....:..|.     ||     .:.||
Zfish   467 --------------LLRYVSEDKTEEFHTGRRSSRRSRRKSEKGGS-----PA-----HYALV-- 505

  Fly   630 PAPPPRPRKQREMTPPAVPPPPPKPASMQPASSITSISIPVPVPVPAAVDPSEISELH-TPSKSR 693
                  |..|.:|.||                  .|::.|.          ||.|.:: |..:|.
Zfish   506 ------PTLQMDMLPP------------------DSLATPT----------SETSSVYLTFDRSS 536

  Fly   694 TLTLKKKHSLMA------KRRNTNLKLLGTGDIQGHLYRRKKNHRGVTY----WARIYFVMLDTI 748
            .|:..||:.|.|      .:|..:.:.||.||.:|.|:::|.   ..:|    |.:.:.|:.|..
Zfish   537 VLSRSKKNKLRAGSLPSISKRRISCRDLGQGDCEGWLWKKKD---AKSYFSQKWKKYWVVLKDAC 598

  Fly   749 LYGFRSKQSTSASLVIFLPGFTVSLAKEVHSKPHAFKVYH-TAKSFYFAAESLDALNQWVDFLRQ 812
            ||.:.:::...|...:.||.|.:..|.|...| .|||..| ..|||||||::::.:|:|:..:..
Zfish   599 LYWYTNEEDEKAEGFVSLPEFNIDQASECRKK-FAFKACHPKIKSFYFAADNIEDMNRWLSLMNM 662

  Fly   813 ASLKVPPSTGSKGGGDAKDLYSENDSSGEECDALVIQNLSTPSPQG---NKESMSMSMTLSGGTP 874
            |:   ...:..|......|.:||:|....:..:...:..|.|.|..   :..|:|.........|
Zfish   663 AA---AAHSEQKRIRQDHDYWSESDHEDADHISSTTKQDSPPPPYDTYPHPTSVSPFQDSQHIRP 724

  Fly   875 PSSAPIKHERGYLDSFRKFTNTFKSSAAKPSSDIPVPTEQYRSYRKVPGGSFGIQIGANTPGYHD 939
            ||:..::       |....:.|...|.:..||.......|.||::.:      |:....:.|.|.
Zfish   725 PSTETVQ-------SRSPLSETQGGSVSSASSPGRKSASQRRSWQDL------IETPLTSSGLHF 776

  Fly   940 PAMPPTQIPPLVGPKLSRSSSRSSVVSGTESAVSLSASILGPPASPAPTP--TPTATPTSLQHQS 1002
                 .|..||        .....|.|.....|.|......|.....||.  .|..|||
Zfish   777 -----LQTLPL--------DDSVFVDSNRTVPVELRRQSTLPAQHGLPTEHFIPPTTPT------ 822

  Fly  1003 SEESPSQSQSQSPSSKSSLKKAPFNFLHASNPNLVEFDFHTSKTLLPKMSVGNTLDHG-----HN 1062
                       .||.|.                            :|.:..|.|:|.|     |
Zfish   823 -----------QPSPKP----------------------------IPALGRGETMDGGGIGSKH- 847

  Fly  1063 IQGFVTLKDLMLR--------KQEEEAQEMYNNRVH---LGVEKHKHARTESTASQQSAMSSSVT 1116
             :.|...:|..|.        .:..:||..:...||   .|.|:.:..:.:|......|:..|..
Zfish   848 -RSFTLPRDSGLHAILAASSAAEHGDAQRYHLGHVHSRDTGGERERRHQADSLVDLYRALERSSL 911

  Fly  1117 KPLEK 1121
            .|:.:
Zfish   912 SPVNE 916

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cnk	NP_725671.1	SAM_CNK1,2,3-suppressor	6..74	CDD:188910	32/67 (48%)
		CRIC_ras_sig	82..165	CDD:463138	25/95 (26%)
		PDZ_CNK1_2_3-like	203..283	CDD:467230	34/81 (42%)
		PH_CNK_insect-like	720..810	CDD:270135	29/94 (31%)
cnksr2b	XP_009293705.1	SAM_CNK1,2,3-suppressor	8..76	CDD:188910	32/67 (48%)
		CRIC_ras_sig	84..182	CDD:463138	26/97 (27%)
		PDZ_CNK1_2_3-like	220..300	CDD:467230	33/79 (42%)
		CNK2_3_dom	345..>475	CDD:461979	34/241 (14%)
		PH_CNK_mammalian-like	555..667	CDD:269962	35/118 (30%)