DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cnk and Ipcef1

DIOPT Version :9

Sequence 1:	NP_001286524.1	Gene:	cnk / 36952	FlyBaseID:	FBgn0286070	Length:	1557	Species:	Drosophila melanogaster
Sequence 2:	XP_011241382.1	Gene:	Ipcef1 / 320495	MGIID:	2444159	Length:	433	Species:	Mus musculus

Alignment Length:	461	Identity:	107/461 - (23%)
Similarity:	174/461 - (37%)	Gaps:	91/461 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   707 RRNTNLKLLGTGDIQGHLYRRKKNHRGV---TYWARIYFVMLDTILYGFRSKQSTSASLVIFLPG 768
            ||..:.|.||..|.||.||  ||..:|.   ..|.:.:.|:..:.||.:.::.:..|...:.|..
Mouse    26 RRRISCKDLGHADCQGWLY--KKKEKGTFLSNKWKKFWVVLKGSSLYWYSNQMAEKADGFVNLSD 88

  Fly   769 FTVSLAKEVHSKPHAFKVYH-TAKSFYFAAESLDALNQWVDFLRQASLKVPPSTGSKGGGDAKDL 832
            |||..|.|. .|.:|||:.| ..|:||||||:|..:|.|::.|..|      .|..:.....::.
Mouse    89 FTVERASEC-KKKNAFKINHPQIKAFYFAAENLQEMNVWLNKLGFA------VTHQESITKDEEC 146

  Fly   833 YSENDSSGEECDALVIQNLSTPSPQGNKESMSMSMTLSGGTPPSSAPIKHERGYLDSFRKFTNTF 897
            |||::....|   :.::  :.|.|..:..|..:....:.....||:|.:.|...  ||....||.
Mouse   147 YSESEQEDPE---VAVE--APPPPYASTTSSPVVRVDAAQWASSSSPKRRETSC--SFSSLENTV 204

  Fly   898 KSSAAKPSSDIPVPTEQYRSYRKVPGGSFGIQIGANTPGYHDPAMPPT---QIPPLVGPKLSRSS 959
            |:.:...||.    :::.:|:..:...|         |...|..:|.|   |:..|...:.|...
Mouse   205 KAPSQFSSSG----SKERQSWHNIVNSS---------PATEDAGLPLTFAEQVHTLAFSEASNCQ 256

  Fly   960 SRSSVVSGTESAV-----SLSASILGPPASPAPTPTPTATPTSLQHQ---SSEESPSQSQSQS-- 1014
            :..:....:|..:     |...|.|.........|...|.......:   |||:...:...:|
Mouse   257 APENNCITSEGGLLNLLSSDDTSSLNNNKDHLTVPDRAAGSRMADREEIKSSEDDEMEKLYKSLE 321

  Fly  1015 -----------PSSKSSLKKAPFNFL-HASNPNLVEFDFHTSKTLLPKMSVGNTLDHGHNIQGFV 1067
                       ||:|..|:|   :|: ...||::.| ..|..:||      .:||
Mouse   322 QASLSPLGDRRPSTKKELRK---SFVKRCKNPSINE-KLHKIRTL------NSTL---------- 366

  Fly  1068 TLKDLMLRKQEEEAQEMYNNRV---HLGVEKHKHARTESTASQQSAMSSSVTKPLEKLPKIQSVS 1129
                    |.:|....|.|..:   .|...|::..:..:|...|........:..|..|  |.|.
Mouse   367 --------KCKEHDLAMINQLLDDPKLTARKYREWKVMNTLLIQDIYQQQAPQDPEVTP--QEVM 421

  Fly  1130 LPKTPD 1135
            .|.:.|
Mouse   422 NPTSSD 427

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cnk	NP_001286524.1	SAM_CNK1,2,3-suppressor	6..74	CDD:188910
		SAM	7..74	CDD:197735
		CRIC_ras_sig	82..165	CDD:287501
		PDZ_signaling	206..283	CDD:238492
		PH	720..814	CDD:278594	34/97 (35%)
		PH_CNK_insect-like	720..810	CDD:270135	33/93 (35%)
Ipcef1	XP_011241382.1	PH_CNK_mammalian-like	25..138	CDD:269962	42/120 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848868
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1738
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1121556at2759
OrthoFinder	1	1.000	-	-		FOG0001221
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	7	6.710