Protein Alignment cnk and Cnksr1

DIOPT Version :10

• Sequence 1: NP_725671.1
• Gene: cnk / 36952
• FlyBaseID: FBgn0286070
• Length: 1557
• Species: Drosophila melanogaster
• Sequence 2: XP_063143520.1
• Gene: Cnksr1 / 298545
• RGDID: 1311879
• Length: 821
• Species: Rattus norvegicus
• Alignment Length: 1211
• Identity: 225/1211 - (18%)
• Similarity: 348/1211 - (28%)
• Gaps: 530/1211 - (43%)

  Fly     6 IAEWTPDQVTDWIKGLDESMKGYLYEFSKQEIGGRALLNIRPYELENLGMLRIGHQEIVLEAVEN 70
            :..|||.:|..|::|||:.::.  |.|...|:.|:.||.:.|..||.|.:..:||||::|..||.
  Rat    68 VETWTPGKVAAWLRGLDDVLQD--YPFEDWELPGKYLLQLCPQNLEALTVWPLGHQELILHGVEQ 130

  Fly    71 LRNFHYHLKNDNLQFMA---LHVATAAKNLHRELARNHAESTKIDTRILHDITRTIATLKPLVGS 132
            ||.....|:.:||:.:|   |....|.::|.:...|:.|| |..|  :|:.....:.....|:..
  Rat   131 LRALGSKLQTENLKSLAQGLLDRTQAFQSLVQGRLRDCAE-TPAD--VLNAAVELVREAHALLSW 192

  Fly   133 LERTPFRKQEMYREYCGNV-LKCGLELATIAHRDRFALQPVPAIRQSAERLENLANFVIQDISDP 196
            |.|..|.....: ..|..: :.|| ||..:...|....:......:...|:..:.:.::....:.
  Rat   193 LNRYLFTHLNDF-SACQEIGVLCG-ELGQVLQEDCLEAEKESNTLRICGRVAGICHNILGCSPEE 255

  Fly   197 MVLQPASLNLVTL---------------KKRESEL---------GFNIESSYNGIHRVTDIKYNS 237
            ::.|.|.|.||.|               ...|::|         |..|.::.|.:|.|:  :...
  Rat   256 LLEQRAVLELVQLDDPSSPGIHVGALPTASTEAKLYLTWPLSLQGLEIHTTSNCLHFVS--RVGV 318

  Fly   238 PAHNSGKIEDGDEIVQINYQTVVGWQHRTVLEHLREALPDVVLTVKKRPKHTKMFGQIYMQPYRL 302
            .|....:|..||||:|||.|.||||.|:.:|..|......|.|.:||.|
  Rat   319 QAATGSQILPGDEIIQINEQVVVGWPHKNMLRELLREPARVSLVLKKIP---------------- 367

  Fly   303 PSKKRNMAARWAAQMPSPRAAFLTLDTEQLATGGTGSAVPD-PSKSLSSEKREVLTKANPVSSAS 366
                                                  ||: |||
  Rat   368 --------------------------------------VPETPSK-------------------- 374

  Fly   367 DSDSSCSDIPTPTD-PKLAAREIRLYYPKPRALLQRRNTICGCEYLSLKNSDLVVPSWHERKPGI 430
                      ||.| |:..::.:.|..|.||                       ||
  Rat   375 ----------TPPDSPQRLSQSLPLNPPSPR-----------------------VP--------- 397

  Fly   431 GSPTNCDPGSPSIRDKSISFGYGLEMAARPTTCIGIAGDTSTDKARRMFHEARKLKQLTEDSQRE 495
                                                                           ||
  Rat   398 ---------------------------------------------------------------RE 399

  Fly   496 FLVDRYKPGVSKVVRFDAKEDYVMKNEKFICNVENTILETFEPIPFADEGDEDALETLRNCKTEN 560
            .|.|
  Rat   400 GLFD------------------------------------------------------------- 403

  Fly   561 AEELLEAINLATKGQDLPLAEAINMPLLQQGRRGRLDKSHSTPAY-DNSGEESDTPPAIEPRKEF 624
                   .||:|.|...|                       :||: |::..::...|
  Rat   404 -------FNLSTDGNPSP-----------------------SPAWTDSTSLDAQPTP-------- 430

  Fly   625 LLVTPPAPP-PRPRKQREMTPPAVPPPPPKPASMQPASSITSISIPVPVPVPAAVDPSEISELHT 688
               |||.|| ..|.:..|                             |:.....:|
  Rat   431 ---TPPGPPGTLPEETAE-----------------------------PLEASGHLD--------- 454

  Fly   689 PSKSRTLTLKKKHSLMAK--RRNTNLKLLGTGDIQGHLYRRK--KNHRGVTYWARIYFVMLDTIL 749
              ||.|:..|....:..:  ||..:.:.||..|..|.|..||  ....|.. |.|.:||:....|
  Rat   455 --KSPTVGRKNSKGIATRLSRRRVSCRELGLPDCDGWLLLRKVPGGFMGAR-WRRCWFVLKGHTL 516

  Fly   750 YGFRSKQST--------------------------SASLVIFLPGFTVSLAKEVHSKPHAFKVYH 788
            |.:|..|.:                          .|..:|.:..:::....: ..|.:.|::.|
  Rat   517 YWYRQPQRSRLVPAPTLQFQGTQCPLLTSVGTQDEKAEGLINISNYSLECGHD-QKKKYVFQLTH 580

  Fly   789 TA-KSFYFAAESLDALNQWVDFLRQASLKVPPSTGSKGGGDAKDLYSENDSSGEECDALVIQNLS 852
            .. |.|.||||:|..|:.||..|.....|. .:.|.......:|.|||.::  |:.|.......:
  Rat   581 DVYKPFIFAAETLSDLSMWVRHLVTCISKY-QTLGRAPSAREEDCYSETEA--EDPDEEAGSRSA 642

  Fly   853 TPSPQGNKESMSMSMTLSGGTPPSSAPIKHERGYLDSFRKFTNTFKSSAAKPSSDIPVPTEQYRS 917
            :|.|          ......|.||::|::..|          .:|.||.  .|||
  Rat   643 SPGP----------AQAWNDTSPSASPLQSPR----------TSFGSSL--DSSD---------- 675

  Fly   918 YRKVPGGSFGIQIGANTPGYHDPAMPPTQIPPLVGPKLSRSSSRSSVVSGTESAVSLSASILGPP 982
             |.:.|...|::.|                                           ..|:||
  Rat   676 -RALEGMVQGLRQG-------------------------------------------GVSLLG-- 694

  Fly   983 ASPAPTPTPTATPTSLQHQSSEESPSQSQSQSPSSKSSLKKAPFNFLHAS-NPNLVEFDFHTSK- 1045
                       .|..|.|:....|                     |:..: :|:|.|   |..:
  Rat   695 -----------QPQPLTHEQWRSS---------------------FMRRNRDPHLNE---HVHRV 724

  Fly  1046 -----TLLPKMSVGNTLDHGHNIQGFVTLKDLMLRKQEEEAQEMYNN--RVHLGVEKHKHARTES 1103
                 ||..|:.....|:   .:.|...|.....|:.:|:..|:|:.  |...|:    .|:|.|
  Rat   725 RALQSTLKAKLQELQVLE---EVLGDPELTGAKFRQWKEQNHELYSEGLRTWGGM----WAQTSS 782

  Fly  1104 TASQQSAMSSSVTKPLEKLPKIQSVSLPKTPDYEISFKPDD 1144
            ......:...| .:||...|:..|...|.||  |.|.:|.|
  Rat   783 PDPNTDSRGQS-PQPLPSDPEEPSQLFPSTP--ENSLQPPD 820

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cnk	NP_725671.1	SAM_CNK1,2,3-suppressor	6..74	CDD:188910	27/67 (40%)
		CRIC_ras_sig	82..165	CDD:463138	21/86 (24%)
		PDZ_CNK1_2_3-like	203..283	CDD:467230	30/103 (29%)
		PH_CNK_insect-like	720..810	CDD:270135	28/118 (24%)
Cnksr1	XP_063143520.1	None