DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cnk and Samd3

DIOPT Version :9

Sequence 1:	NP_001286524.1	Gene:	cnk / 36952	FlyBaseID:	FBgn0286070	Length:	1557	Species:	Drosophila melanogaster
Sequence 2:	XP_006512805.1	Gene:	Samd3 / 268288	MGIID:	2685469	Length:	527	Species:	Mus musculus

Alignment Length:	296	Identity:	55/296 - (18%)
Similarity:	105/296 - (35%)	Gaps:	101/296 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 WTPDQVTDWIKGLDESMKGYLYEFSKQEIGGRALLNIRPYELENLGMLRIGHQEIVLEAVENLRN 73
            |:.|||..|:  :::::...:..|.::|:.|..||.:....::.| :.:||||.::::.::..:.
Mouse    17 WSVDQVCKWL--VEKNLGELVPRFQEEEVSGATLLALNDRMVQQL-VKKIGHQAVLMDFIKKYKQ 78

  Fly    74 FHYHLKN---------------------------------------DNLQFMALHVATAAKNLHR 99
            .:..||.                                       || :.:...|....:|:..
Mouse    79 GNQELKPTGGPADTSTLTPAQAAPEHEQNPSPTSHGDQTSLYPAVLDN-RLIDQRVLKQRRNVKH 142

  Fly   100 ELARNHA---------------------ESTKID----TRILH----DITRTIATLKPLVGSLER 135
            .|||:.|                     |..:.|    .||:.    |:|      |.|.|||..
Mouse   143 VLARHKALQWTKSYILPEFPYDVKCMLVEQKRPDHSMRIRIIEFLQADMT------KYLEGSLYP 201

  Fly   136 TPFRKQEMYREYCGNVLK---------CGLELATIAHRDRFALQPVPAIRQSAERLENLANF--- 188
            |    .:.|.:....:|:         ||..|...|.:|||.....| |....:.:.|...|
Mouse   202 T----TQQYNDVVNALLQAHPFLDEDGCGFFLWKRALKDRFKYIRRP-IEDDEQVMRNKCKFGHR 261

  Fly   189 ---VIQDISDPMVLQPASLNLVTLKKRESELGFNIE 221
               ..:.::|   :|...:.:|.:|:..:.|...::
Mouse   262 RGQTRKSLAD---IQSNEIKIVQIKEESAHLDSEVD 294

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cnk	NP_001286524.1	SAM_CNK1,2,3-suppressor	6..74	CDD:188910	15/64 (23%)
		SAM	7..74	CDD:197735	15/64 (23%)
		CRIC_ras_sig	82..165	CDD:287501	25/120 (21%)
		PDZ_signaling	206..283	CDD:238492	3/16 (19%)
		PH	720..814	CDD:278594
		PH_CNK_insect-like	720..810	CDD:270135
Samd3	XP_006512805.1	SAM_Samd3	14..79	CDD:188925	15/64 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848869
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930