Protein Alignment: cnk and Cnksr2

• Sequence 1: NP_001286524.1
• Gene: cnk
• FlyBaseID: FBgn0286070
• Length: 1557
• Species: Drosophila melanogaster
• Sequence 2: NP_808419.1
• Gene: Cnksr2
• MGIID: 2661175
• Length: 1032
• Species: Mus musculus
• Alignment Length: 1233
• Identity: 289/1234 (23%)
• Similarity: 470/1234 (38%)
• Gaps: 340/1234 (28%)

  Fly     6 IAEWTPDQVTDWIKGLDESMKGYLYEFSKQEIGGRALLNIRPYELENLGMLRIGHQEIVLEAVEN 70
            :::|:|.||.||:||||:.::.|:..|.:::|.|..||.|...|||:||:.||||||::||||:.
Mouse     8 VSKWSPSQVVDWMKGLDDCLQQYIKNFEREKISGDQLLRITHQELEDLGVSRIGHQELILEAVDL 72

  Fly    71 LRNFHYHLKNDNLQFMALHVATAAKNLHRELA----RNHAE---STKIDTRILHDITRTIATLKP 128
            |...:|.|:.:||:.::..:..:||||...:.    ..|.:   |.|:....|..:...|...|.
Mouse    73 LCALNYGLETENLKTLSHKLNASAKNLQNFITGRRRSGHYDGRTSRKLPNDFLTSVVDLIGAAKS 137

  Fly   129 LVGSLERTPFRKQEMYREYCGNVLKCGLELATIAHRDRFALQPVPAIRQSAERLENLANFVIQDI 193
            |:..|:|:||.....|.....||::..|||.||..:|....:....|....:.|..:.:.:|...
Mouse   138 LLAWLDRSPFAAVTDYSVTRNNVIQLCLELTTIVQQDCTVYETENKILHVCKTLSGVCDHIISLS 202

  Fly   194 SDPMVLQPASLNLVTLK--KRESELGFNIESSYNGIHRVTDIKYNSPAHNSGKIEDGDEIVQINY 256
            |||:|.|.|.|.::.|.  |....||..|:|:|:|:|.:|....||||....||..|||::|:|:
Mouse   203 SDPLVSQSAHLEVIQLANIKPSEGLGMYIKSTYDGLHVITGTTENSPADRCKKIHAGDEVIQVNH 267

  Fly   257 QTVVGWQHRTVLEHLREALPDVVLTVKKRPKHTKMFGQIYMQPYRLPSKKRNMAARW---AAQMP 318
            |||||||.:.::..|||....|:||:||||:....         ..|:..:||  ||   |.|..
Mouse   268 QTVVGWQLKNLVNALREDPSGVILTLKKRPQSMLT---------SAPALLKNM--RWKPLALQPL 321

  Fly   319 SPRAAFLTLDTEQLATGGTGSAVPDPSKSLSSEKREVLTKANPVSSASDSDSSC-SDI---PTPT 379
            .||:                     |:.|       |.|.::.:|:.:..|||. .|:   |.|.
Mouse   322 IPRS---------------------PTSS-------VATPSSTISTPTKRDSSALQDLYIPPPPA 358

  Fly   380 DPKLAAREIRLYYPKPRALLQRRNTICGCEYLSLKNSDLVVPSWHERKPGIGSPTNCDPGSPS-- 442
            :|         |.|:.    ::.|..|         .||       |...:|.|.:....||:
Mouse   359 EP---------YIPRD----EKGNLPC---------EDL-------RGHMVGKPVHKGSESPNSF 394

  Fly   443 -----------IRDKSISFGYGLEMAARPTTCIGIAGDTSTDKARRMFHEARKLKQLTEDSQREF 496
                       :.:.::.:.|..|           .|.:|:...|.......||:.::...:..:
Mouse   395 LDQEYRKRFNIVEEDTVLYCYEYE-----------KGRSSSQGRRESTPTYGKLRPISMPVEYNW 448

  Fly   497 LVDRYKPGVSKVVRFDAKEDYV---MKNEKFICNVENTILETFEPIPFADEGDEDALETLRNCKT 558
            :.|...|  :|:.|...:|:.:   |.|||..                     ::.....||.|.
Mouse   449 VGDYEDP--NKMKRDSRRENSLLRYMSNEKIA---------------------QEEYMFQRNSKK 490

  Fly   559 ENAEELLEAINLATKGQDLPLAEAINMPLLQQGRRGRLDKSHSTPAYDNSGEESDTPPAIEPRKE 623
            :..:                          :..::|  |||:|...|
Mouse   491 DTGK--------------------------KSKKKG--DKSNSPAHY------------------ 509

  Fly   624 FLLVTPPAPPPRPRKQREMTPPAVPPPPPKPASMQPASSITSIS---IPVPVPVPAAVDPSEISE 685
                                            |:.|:..:.::.   :..|||........:.|.
Mouse   510 --------------------------------SLLPSLQMDALRQDIMGTPVPETTLYHTFQQSS 542

  Fly   686 LHTPSKSRTLTLKKKHSLMAK-RRNTNLKLLGTGDIQGHLYRRKKNHRGVTY----WARIYFVML 745
            |...||.     |.|.::..| :|..:.|.||.||.:|.|:::|.   ..:|    |.:.:||:.
Mouse   543 LQHKSKK-----KNKGAISGKSKRRISCKDLGRGDCEGWLWKKKD---AKSYFSQKWKKYWFVLK 599

  Fly   746 DTILYGFRSKQSTSASLVIFLPGFTVSLAKEVHSKPHAFKVYH-TAKSFYFAAESLDALNQWVDF 809
            |..||.:.:::...|...|.||.|.:..|.|...| :|||..| ..||||||||.||.:|:|::.
Mouse   600 DASLYWYINEEDEKAEGFISLPEFKIDRASECRKK-YAFKACHPKIKSFYFAAEHLDDMNRWLNR 663

  Fly   810 LRQASLKVPPSTGSKGGGDAKDLYSENDSSGEECDALVIQNLSTPSPQGNKESMSMSMTLS---- 870
            :...:.........|   ..:|.:||:|.  ||.|........:|.|..:......||:.:
Mouse   664 INMLTAGYAERERIK---QEQDYWSESDK--EEADTPSTPKQDSPPPPYDTYPRPPSMSCASPYV 723

  Fly   871 -------GGTPPSSAPIKHERGYLDSFRKFTNTFKSSAAKPSSDIPVPTEQYRSYR---KVPGGS 925
                   ..|..|.:...||     .||:  ....|||..|   |.....|.||::   :.|..|
Mouse   724 EAKHSRLSSTETSQSQSSHE-----EFRQ--EVTGSSAVSP---IRKTASQRRSWQDLIETPLTS 778

  Fly   926 FGIQI--------------GANTPGYHDPAMPPTQ---IPPLVGPKLSRSSSRSSVVSGTESA-- 971
            .|:..              .|.:|.:...:..|||   :....||.....|.|..|::|....
Mouse   779 SGLHYLQTLPLEDSVFSDSAAISPEHRRQSTLPTQKCHLQDHYGPYPLAESERMQVLNGNGGKPR 843

  Fly   972 -------VSLSASILGPPASPAPTPTPTATPTSLQHQSSEESPS--------------------- 1008
                   ...:...|..|.| |..|.....|..::.:..||...
Mouse   844 SFTLPRDSGFNHCCLNTPVS-ACDPQDDIQPPEVEEEEEEEEEEAAGENVGEKNENREEKLGDSL 907

  Fly  1009 -------QSQSQSP------SSKSSLKKAPFNFLHASNPNLVEFDFHTSKTLLPKMSVGNTLDHG 1060
                   :..|.||      |:|...|   .:|:...|..::....|..:.|...:...
Mouse   908 QDLYRALEEASLSPLGEHRISTKMEYK---LSFIKRCNDPVMNEKLHRLRILKSTLKAR------ 963

  Fly  1061 HNIQGFVTLKDLML------RKQEEEAQEMYNNRVHLGVEKHKHARTE-STASQQSAMSSSVT 1116
               :|.|.:.|.:|      .|:.::.::||.: :.|.:.:...:... |.:|:...::||:|
Mouse   964 ---EGEVAIIDKVLDNPDLTSKEFQQWKQMYLD-LFLDICQSTTSNDPLSISSEVDVLTSSLT 1022

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cnk	NP_001286524.1	SAM_CNK1,2,3-suppressor	6..74	CDD:188910	33/68 (49%)
		SAM	7..74	CDD:197735	33/67 (49%)
		CRIC_ras_sig	82..165	CDD:287501	25/90 (28%)
		PDZ_signaling	206..283	CDD:238492	34/79 (43%)
		PH	720..814	CDD:278594	34/99 (34%)
		PH_CNK_insect-like	720..810	CDD:270135	34/95 (36%)
Cnksr2	NP_808419.1	SAM_CNK1,2,3-suppressor	8..76	CDD:188910	33/68 (49%)
		SAM	8..73	CDD:197735	32/65 (49%)
		CRIC_ras_sig	84..176	CDD:287501	26/92 (28%)
		Peptidase_C98	139..>218	CDD:292138	23/79 (29%)
		PDZ_signaling	222..294	CDD:238492	33/72 (46%)
		DUF1170	341..561	CDD:284152	55/366 (15%)
		PH_CNK_mammalian-like	559..672	CDD:269962	40/117 (34%)
		PH	573..669	CDD:278594	34/100 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930				C61946217
eggNOG	1	0.900				E1_KOG1738
Hieranoid	1	1.000
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3002
Isobase	1	0.950		0	Normalized mean entropy	S6579
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010				D1121556at2759
OrthoFinder	1	1.000				FOG0000782
OrthoInspector	1	1.000				T616056
orthoMCL	1	0.900				OOG5_130611
Panther	1	1.100			O	PTHR12844
Phylome	1	0.910		0.667	Consistency score
RoundUp	1	1.030		avgDist	Average_Evolutionary_Distance	R3250
TreeFam	1	0.960
	13	12.740