Protein Alignment cnk and cnksr2

DIOPT Version :10

• Sequence 1: NP_725671.1
• Gene: cnk / 36952
• FlyBaseID: FBgn0286070
• Length: 1557
• Species: Drosophila melanogaster
• Sequence 2: XP_012811699.2
• Gene: cnksr2 / 100101685
• XenbaseID: XB-GENE-490704
• Length: 1068
• Species: Xenopus tropicalis
• Alignment Length: 1255
• Identity: 298/1255 - (23%)
• Similarity: 471/1255 - (37%)
• Gaps: 350/1255 - (27%)

  Fly     6 IAEWTPDQVTDWIKGLDESMKGYLYEFSKQEIGGRALLNIRPYELENLGMLRIGHQEIVLEAVEN 70
            :::|||.||.||:||||:.::.|:..|.:::|.|..||.|...|||.||:.||||||::||||:.
 Frog     8 VSKWTPSQVVDWMKGLDDCLQQYIKNFEREKIAGDQLLRITHQELEELGVTRIGHQELILEAVDL 72

  Fly    71 LRNFHYHLKNDNLQFMALHVATAAKNLHRELA----RNHAE---STKIDTRILHDITRTIATLKP 128
            |...:|.|:.:||:.::..:.::||||...:.    ..|.:   |.|:....|..:...|.:.|.
 Frog    73 LCALNYGLETENLKTLSHKLNSSAKNLQNFITGRRRSGHYDGKSSRKLPNDFLTSVVDLIGSAKS 137

  Fly   129 LVG-----------------------SLERTPFRKQEMYREYCGNVLKCGLELATIAHRDRFALQ 170
            |:.                       .|:::||.....|.....||::..|||.||..::....:
 Frog   138 LLAWLDRYCHADQDDIDNLKKRWIGHKLDKSPFAAVTDYSVTRNNVIQLCLELTTIVQQECTVYE 202

  Fly   171 PVPAIRQSAERLENLANFVIQDISDPMVLQPASLNLVTLK--KRESELGFNIESSYNGIHRVTDI 233
            ....|....:.|..:.:.:|...|||:|.|.|.|.::.|.  |....||..|:|:|:|:|.:|..
 Frog   203 TENKILHVCKTLSGVCDHIISLSSDPLVSQSAHLEVIQLSNIKPSEGLGMYIKSTYDGLHVITGT 267

  Fly   234 KYNSPAHNSGKIEDGDEIVQINYQTVVGWQHRTVLEHLREALPDVVLTVKKRPKHTKMFGQIYMQ 298
            ..||||....||..|||::|:|:|||||||.:.::..|||....|:||:||||:....
 Frog   268 TENSPADRCKKIHAGDEVIQVNHQTVVGWQLKNLVNALREDPSGVILTLKKRPQSMLT------- 325

  Fly   299 PYRLPSKKRNMAARWAAQMPSPRAAFLTLDTEQLATGGTGSAVPDPSKSLSSEKREVLTKANPVS 363
              ..|:..:||  ||..      .|....|.|.              |:.|..:...|...:|.|
 Frog   326 --SAPALLKNM--RWKP------LALQWYDEEM--------------KTYSWTRISPLIPRSPTS 366

  Fly   364 SASDSDSSCSDIPTPTDPKLAAREIRLYYPKPRALLQRRNTICGCEYLSLKNSDLVVPSWHERKP 428
            .|:...|:   |.|||....:|.:                             ||.:|
 Frog   367 GAATPSST---ISTPTKRDSSALQ-----------------------------DLFIP------- 392

  Fly   429 GIGSPTNCDPGSPSIRDKSISFGYGLEMAARPTTCIGIAGDTSTDKARRMFHEARKLKQLTEDSQ 493
                |...:|..|  ||:.                    |:...:...|  |...|......:|.
 Frog   393 ----PPPPEPYIP--RDEK--------------------GNLPCEDMTR--HTVGKPVSKGSESP 429

  Fly   494 REFLVDRYKPGVSKVVRFDAKEDYVMKNEKFICNVENTILETFE--------------------- 537
            ..||...|:.      .|:..|             |:.||..:|
 Frog   430 NSFLDQEYRK------HFNVVE-------------EDAILYCYEYDKGRSGMQGRRESTPTYGKL 475

  Fly   538 -----PIPFADEGD-EDALETLRNCKTENAEELLEAINLATKGQDLPLAEAINMPLLQQGRRGRL 596
                 |:.:...|| ||..:..|:.:.|::  ||..|:     .|..:.|..   :||:|.:...
 Frog   476 RPISMPVEYNWVGDYEDPNKIKRDSRRESS--LLRYIS-----NDKVIQEEY---MLQRGTKKET 530

  Fly   597 DKSHSTPAYDNSGEESDTPPAIEPRKEFLLVTPPAPPPRPRKQREMTPPAVPPPPPKPASMQPAS 661
            .|...     ..||::.:|      ..:.|:                               ||.
 Frog   531 GKKSK-----KKGEKNTSP------SHYALI-------------------------------PAV 553

  Fly   662 SITSISIPVPVPVPAAVDPSEISELHTPSKSRTLTLKKKHSL-----MAKRRNTNLKLLGTGDIQ 721
            .:.|:...|..|     ..|:.:..||..:|......||.:.     .:||| .:.|.||.||.:
 Frog   554 QMDSLCHEVVSP-----SVSDAASYHTFQQSSLQHKSKKRNKGPVPGKSKRR-ISCKDLGRGDCE 612

  Fly   722 GHLYRRKKNHRGVTY----WARIYFVMLDTILYGFRSKQSTSASLVIFLPGFTVSLAKEVHSKPH 782
            |.|:::|.   ..:|    |.:.:|::.||.||.:.:::...|...|.||.|.:..|.|...| .
 Frog   613 GWLWKKKD---AKSYFSQKWKKYWFILKDTSLYWYINEEEEKAEGFISLPEFKIDRASECRKK-F 673

  Fly   783 AFKVYH-TAKSFYFAAESLDALNQWVDFLRQASLKVPPSTGSKGGGDAKDLYSENDSSGEECDAL 846
            |||..| ..|||||||::||.:|:|:..:..|..........|....:.:.:||:|.  ||.|..
 Frog   674 AFKACHPKIKSFYFAADNLDDMNRWLSRVNLAVSSYAERERIKQDQGSINYWSESDQ--EEVDTP 736

  Fly   847 VIQNLSTPSPQGNKESMSMSMTLSGGTPPSSAPIKHERGYLDSFRKFTN--TFKSSAAKPSSDIP 909
            ......:|.|..:......||:.:.   |...| ||.....::.:..::  .|:..||..::|.|
 Frog   737 STPKQDSPPPPYDTYPRPASMSCAS---PFVEP-KHRLSSTETSQSHSSHEEFRQEAAGSTTDSP 797

  Fly   910 V--PTEQYRSYR---KVPGGSFGIQIGANTPGYHDPAMPPTQIPP-------LVGPKL------- 955
            |  ...|.||::   :.|..|.|:......|......:.|..:.|       |..||.
 Frog   798 VRKTASQRRSWQDLIETPLTSSGLHYLQTLPLEDSVFLEPAVVSPDHRRQSTLPAPKCHLLDHYG 862

  Fly   956 ---------SRSSSRS------------------------SVVSGTESAVSLSASILGPPASPAP 987
                     |::.|.|                        |::...||:..|...  |...|..|
 Frog   863 PFSLAECKQSQAQSGSGAKPRSFTLPRDGGLSHCAPLSPVSILEPLESSPKLETQ--GEAKSDQP 925

  Fly   988 TPTPTATPTSLQHQSSEESPSQS----------QSQSP------SSKSSLKKAPFNFLHASNPNL 1036
            .....||.|      .:|.|:.|          .|.||      |:|...||   :|:...:..:
 Frog   926 GKVEDATET------VDEKPADSLQDLYRALEQASLSPLGDRRLSTKVEYKK---SFIKRCSDPV 981

  Fly  1037 VEFDFHTSKTLLPKMSVGNTLDHGHNIQGFVTLKDLMLRKQE---EEAQEMYNNRVHLGVE---K 1095
            |....|..:.|...:...         :|.|.:.|.:|.|.:   ::.||..:..:.|.:|   |
 Frog   982 VNEKLHRLRILKSTLKAK---------EGEVAIIDKLLEKPDFTSKDFQEWKSLYLELFLEICQK 1037

  Fly  1096 HKHARTESTASQQSAMSSSV 1115
            ......||.:|:..|:..|:
 Frog  1038 SNSKDGESVSSEVDALIQSL 1057

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cnk	NP_725671.1	SAM_CNK1,2,3-suppressor	6..74	CDD:188910	34/67 (51%)
		CRIC_ras_sig	82..165	CDD:463138	24/112 (21%)
		PDZ_CNK1_2_3-like	203..283	CDD:467230	35/81 (43%)
		PH_CNK_insect-like	720..810	CDD:270135	33/94 (35%)
cnksr2	XP_012811699.2	SAM_CNK1,2,3-suppressor	8..76	CDD:188910	34/67 (51%)
		CRIC_ras_sig	84..199	CDD:463138	24/114 (21%)
		PDZ_CNK1_2_3-like	237..317	CDD:467230	34/79 (43%)
		CNK2_3_dom	377..>524	CDD:461979	39/239 (16%)
		PH_CNK_mammalian-like	597..710	CDD:269962	42/117 (36%)