Protein Alignment Amy-d and AMY2A

DIOPT Version :10

• Sequence 1: NP_523768.1
• Gene: Amy-d / 36932
• FlyBaseID: FBgn0000078
• Length: 494
• Species: Drosophila melanogaster
• Sequence 2: NP_000690.1
• Gene: AMY2A / 279
• HGNCID: 477
• Length: 511
• Species: Homo sapiens
• Alignment Length: 512
• Identity: 272/512 - (53%)
• Similarity: 338/512 - (66%)
• Gaps: 24/512 - (4%)

  Fly     5 KSIVCLSLLAVANAQFDTNYASGRSGMVHLFEWKWDDIAAECENFLGPNGYAGVQVSPVNENAV- 68
            |..:.|..:....||:..|...||:.:||||||:|.|||.|||.:|.|.|:.||||||.|||..
Human     2 KFFLLLFTIGFCWAQYSPNTQQGRTSIVHLFEWRWVDIALECERYLAPKGFGGVQVSPPNENVAI 66

  Fly    69 -KDSRPWWERYQPISYKLETRSGNEEQFASMVKRCNAVGVRTYVDVVFNHM---AADGGTYGTGG 129
             ...|||||||||:||||.||||||::|.:||.|||.||||.|||.|.|||   |...||..|.|
Human    67 YNPFRPWWERYQPVSYKLCTRSGNEDEFRNMVTRCNNVGVRIYVDAVINHMCGNAVSAGTSSTCG 131

  Fly   130 STASPSSKSYPGVPYSSLDFNP-TCA-----ISNYNDANEVRNCELVGLRDLNQGNSYVQDKVVE 188
            |..:|.|:.:|.||||..|||. .|.     |.|||||.:||:|.|.||.||.....||:.|:.|
Human   132 SYFNPGSRDFPAVPYSGWDFNDGKCKTGSGDIENYNDATQVRDCRLTGLLDLALEKDYVRSKIAE 196

  Fly   189 FLDHLIDLGVAGFRVDAAKHMWPADLAVIYGRLKNLNTDHGFASGSKAYIVQEVIDMGGEAISKS 253
            :::||||:||||||:||:|||||.|:..|..:|.|||: :.|.:|||.:|.|||||:|||.|..|
Human   197 YMNHLIDIGVAGFRLDASKHMWPGDIKAILDKLHNLNS-NWFPAGSKPFIYQEVIDLGGEPIKSS 260

  Fly   254 EYTGLGAITEFRHSDSIGKVFR--GKDQLQYLTNWGTAWGFAASDRSLVFVDNHDNQRGHGAGGA 316
            :|.|.|.:|||::...:|.|.|  ..:::.||.|||..|||..|||:||||||||||||||||||
Human   261 DYFGNGRVTEFKYGAKLGTVIRKWNGEKMSYLKNWGEGWGFVPSDRALVFVDNHDNQRGHGAGGA 325

  Fly   317 DVLTYKVPKQYKMASAFMLAHPFGTPRVMSSFSFTDTDQ---------GPPTTDGHNIASPIFNS 372
            .:||:...:.||||..||||||:|..|||||:.:....|         |||..:| .|.....|.
Human   326 SILTFWDARLYKMAVGFMLAHPYGFTRVMSSYRWPRQFQNGNDVNDWVGPPNNNG-VIKEVTINP 389

  Fly   373 DNSCSGGWVCEHRWRQIYNMVAFRNAVGLDEIQNWWDSGSNQISFSRGSRGFVAFNNDNYDLNSS 437
            |.:|...||||||||||.|||.|||.|......||:|:||||::|.||:|||:.||||::..:.:
Human   390 DTTCGNDWVCEHRWRQIRNMVIFRNVVDGQPFTNWYDNGSNQVAFGRGNRGFIVFNNDDWSFSLT 454

  Fly   438 LQTGLPAGTYCDVISGSKSGSSCTGKTVTVGSDGRASIYIGSSEDDGVLAIHVNAKL 494
            ||||||||||||||||.|...:|||..:.|..||:|...|.:|.:|..:|||..:||
Human   455 LQTGLPAGTYCDVISGDKINGNCTGIKIYVSDDGKAHFSISNSAEDPFIAIHAESKL 511

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Amy-d	NP_523768.1	AmyAc_bac_euk_AmyA	28..399	CDD:200456	216/392 (55%)
		Aamy_C	405..493	CDD:214749	47/87 (54%)
AMY2A	NP_000690.1	AmyAc_bac_euk_AmyA	25..416	CDD:200456	216/392 (55%)
		Aamy_C	422..510	CDD:214749	47/87 (54%)