Protein Alignment Mov10 and HCS1

DIOPT Version :10

• Sequence 1: NP_611185.3
• Gene: Mov10 / 36922
• FlyBaseID: FBgn0034187
• Length: 764
• Species: Drosophila melanogaster
• Sequence 2: NP_012908.1
• Gene: HCS1 / 853852
• SGDID: S000001500
• Length: 683
• Species: Saccharomyces cerevisiae
• Alignment Length: 739
• Identity: 171/739 - (23%)
• Similarity: 301/739 - (40%)
• Gaps: 184/739 - (24%)

  Fly    19 NQDLSANNSVFGDFMKTKRLEFYNVCSVMQTLLTIDDLSNMELYAQLIQSDVPVQRV------SK 77
            |::|:   |.|...:|.:|.:.....|.:.|.|:|.         ||:|:.:.:..:      |.
Yeast     2 NKELA---SKFLSSIKHEREQDIQTTSRLLTTLSIQ---------QLVQNGLAINNIHLENIRSG 54

  Fly    78 LTYKITFKSTPVNAEDFVAPNL-------------DQVVLVPKASLLASPLPKQLVLALLPHPHE 129
            |..|:..:         :.|||             ..:|||..|....:...|
Yeast    55 LIGKLYME---------LGPNLAVNDKIQRGDIKVGDIVLVRPAKTKVNTKTK------------ 98

  Fly   130 DLEPGDPMLRHVAS------------VDKVSSTTVHVRFSRKHKAV----LSGQRFYAIIRSRRL 178
                  |.::.|:.            |.|:|.|.:.:........:    .|..:.|.:..:..:
Yeast    99 ------PKVKKVSEDSNGEQAECSGVVYKMSDTQITIALEESQDVIATTFYSYSKLYILKTTNVV 157

  Fly   179 TIRYMYRALNLLQE--SPL---VRRYLFPFPSWLTQLVDNSQIKVCCDGHLPNWMQGRPQEPAT- 237
            |...|...:..|.|  ||:   :.:||                           :..||..|.|
Yeast   158 TYNRMESTMRKLSEISSPIQDKIIQYL---------------------------VNERPFIPNTN 195

  Fly   238 --PTSLSLLNSTIYSNAEQLEAVQRIVAGPSTQGPYILFGPPGTGKTTTIVEAILQLRLQQPQSR 300
              ....|.||..:  |..|..|:...:....|    |:.||||||||.|::|.|.||.::.|:.|
Yeast   196 SFQNIKSFLNPNL--NDSQKTAINFAINNDLT----IIHGPPGTGKTFTLIELIQQLLIKNPEER 254

  Fly   301 ILVTAGSNSACDTIALKLCEYIESNIRLQ-EHFAQQKLPEPDHQLIRVYSRSIYEKGFA-SVPSL 363
            ||:...||.:.|||..:|...:.:|:.|: .|.|:.......|.|..:..::...|..: .:..|
Yeast   255 ILICGPSNISVDTILERLTPLVPNNLLLRIGHPARLLDSNKRHSLDILSKKNTIVKDISQEIDKL 319

  Fly   364 L-----LKNSNCSKSIYDHIKASR--------------IVKYGIIVAT--------LCTVARLVT 401
            :     |||....|..::.||..|              |::..|:|.|        ||::.|  .
Yeast   320 IQENKKLKNYKQRKENWNEIKLLRKDLKKREFKTIKDLIIQSRIVVTTLHGSSSRELCSLYR--D 382

  Fly   402 DTLGRYNFFTHIFIDEAGASTEPEALIGIMGIKQTADCHVILSGDHKQLGAVIKSNRAASL--GL 464
            |.  .:..|..:.|||...:.||:..|.::. .|.....::|:||:|||...||:....::  .|
Yeast   383 DP--NFQLFDTLIIDEVSQAMEPQCWIPLIA-HQNQFHKLVLAGDNKQLPPTIKTEDDKNVIHNL 444

  Fly   465 SRSLMERLLQSDCYKSDENGNYDRNRQMRLCR-NYRSHPQIVRLFNELYYNGELKAQA------- 521
            ..:|.:|:::.          :.:...::... .||.:.:|:...:...|||:|.|.|
Yeast   445 ETTLFDRIIKI----------FPKRDMVKFLNVQYRMNQKIMEFPSHSMYNGKLLADATVANRLL 499

  Fly   522 ---PAMDVNLAANWSVLTNPQFPIIFQATHGVTNRE--QNST---SSYNNLEAEVICWYVKRLIN 578
               |.:|...:.:..   :.:.|:|:..|.|...:|  ..:|   |.||..|..::..:::.|.:
Yeast   500 IDLPTVDATPSEDDD---DTKIPLIWYDTQGDEFQETADEATILGSKYNEGEIAIVKEHIENLRS 561

  Fly   579 DRVVGQEDVGIVAPYTAQGKLVTKLLQSK-GYPNVEVGSVETYQGREKTIIIASLVKSFT--NMG 640
            .. |.:..:|:::||.||...:.||:..: ...::|:.:|:.:|||||.:||.|||:|..  .:|
Yeast   562 FN-VPENSIGVISPYNAQVSHLKKLIHDELKLTDIEISTVDGFQGREKDVIILSLVRSNEKFEVG 625

  Fly   641 FMCNPRRVNVLLSRAKALLILVGN 664
            |:...||:||.::|.:..|::|||
Yeast   626 FLKEERRLNVAMTRPRRQLVVVGN 649

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mov10	NP_611185.3	DEXXQc_Helz-like	251..499	CDD:350796	70/279 (25%)
		DNA2	<388..684	CDD:440729	80/306 (26%)
HCS1	NP_012908.1	TIGR00376	15..679	CDD:273041	166/723 (23%)