Protein Alignment Mov10 and dbl8

DIOPT Version :10

• Sequence 1: NP_611185.3
• Gene: Mov10 / 36922
• FlyBaseID: FBgn0034187
• Length: 764
• Species: Drosophila melanogaster
• Sequence 2: NP_596055.1
• Gene: dbl8 / 2540523
• PomBaseID: SPBC29A10.10C
• Length: 1944
• Species: Schizosaccharomyces pombe
• Alignment Length: 937
• Identity: 215/937 - (22%)
• Similarity: 352/937 - (37%)
• Gaps: 270/937 - (28%)

  Fly    15 EANT--NQDLSANNSV-FGDF--MKTKRLEFYNVCSVMQTLLTIDDLSNMELYAQLIQSDVPVQR 74
            |||:  ::.|.....: |.||  :|||.:       |..|.|..:...:.:|....:..||
pombe  1006 EANSHASKSLPQRRQIQFLDFDSLKTKNV-------VHPTQLRRNTQQSAQLARLRLNPDV---- 1059

  Fly    75 VSKLTYKITFKSTPVNAEDFVAPNLDQVVLVPKASLLASPLPKQLVLALLPH----------PHE 129
              :..||:.....|: |:.|.|.|::...:..|.:...|...:::...:|.|          ..:
pombe  1060 --QEFYKVILGWNPL-ADSFSASNVEMQCVQAKFTYNDSNAYEKVFKPMLFHECWAQVKSAVEEK 1121

  Fly   130 DLEPGDPMLRHVASVDK------VSSTTVHVRFSRK------HKAVLSGQ----------RFYAI 172
            ...|.|.:|...::||.      .|.:...|.|...      .|:..||.          :..:|
pombe  1122 QYPPIDLILNTRSTVDNFVDIYFTSCSPTEVSFLSDTDICLLSKSQSSGDTNNPKSFQLCKIQSI 1186

  Fly   173 IR---SRRLTIRYMYRALNLLQESPLVR---RYLFPFPSWLTQLVDNSQIKVCCDGHLP------ 225
            .|   |..|.:|....:::|.:.:|.:|   :.||...:.|.:......::     |||
pombe  1187 SRKKESLELCLRMNIESIDLQEYAPNIRFTAQKLFNATTSLREFAALKSLR-----HLPLSQRIL 1246

  Fly   226 ---------NWMQGRPQEPATPTSLSLLNSTIYSNAEQLEAVQRIVAGPSTQGPYILFGPPGTGK 281
                     |:...:.|:         :..:...|..|..|   |.|.....|..::.|||||||
pombe  1247 DANVTRLPSNFTDDKKQK---------IMKSYGVNEPQAYA---IYASSVNDGFTLIQGPPGTGK 1299

  Fly   282 TTTI---VEAILQ-----LRLQQP-------QSRILVTAGSNSACDTIALKLCEYIESNIRLQEH 331
            |.||   :.|:|.     |:...|       :::||:.|.||:|.|.|.|::
pombe  1300 TKTILGMIGAVLTSSSQGLQFNVPGQTRKTSKNKILICAPSNAAIDEILLRI------------- 1351

  Fly   332 FAQQKLPEPDHQLIRVY----------SRSIYEKGFASVPSLL-------LK------NSNCSKS 373
                |....||:.|:.:          |.|::.|.|.....::       ||      ||:.::.
pombe  1352 ----KAGVYDHEGIKFFPKVIRVGFGDSISVHAKEFTLEEQMIKQMELTNLKKDQEANNSSDTRK 1412

  Fly   374 IYDHIKASR------IVKY-------GIIVATLCTV----------------------------- 396
            .||.|...|      :.|:       .|:.|.|..:
pombe  1413 KYDSIIKKRDSLREDLEKFRSTGKNSSILEAQLREITKQKNMLEQSLDDMRERQRSTNRNLDVLK 1477

  Fly   397 ----------ARLVTDTLGRYNF---------FTHIFIDEAGASTEPEALIGIMGIKQTADCHVI 442
                      |.:|..||.....         |..:.||||..:.|   |..|:.:|...:..|:
pombe  1478 KQIQNQLLQEADIVCATLSASGHELLLNAGLTFRTVIIDEAAQAVE---LSSIIPLKYGCESCVM 1539

  Fly   443 LSGDHKQLGAVIKSNRAASLGLSRSLMERLL----QSDCYKSDENGNYDRNRQMRLCRNYRSHPQ 503
            : ||..||...:.|..:|..|.|:||..|:.    :|.|..|.:               ||.:|:
pombe  1540 V-GDPNQLPPTVLSKTSAKFGYSQSLYVRMFKQHNESACLLSIQ---------------YRMNPE 1588

  Fly   504 IVRLFNELYYNGELKAQAPAMDVNLAANWSVLTNPQFPII-FQATHGVTNREQNSTSSYNNLEAE 567
            |.|..::.:||.:| ...|.|....:..|.  .:||..|. |...|| |....||.|.||..||.
pombe  1589 ISRFPSKFFYNSKL-LDGPNMSAVTSRPWH--EDPQLGIYRFFNVHG-TEAFSNSKSLYNVEEAS 1649

  Fly   568 VICWYVKRLI----NDRVVGQEDVGIVAPYTAQGKLVTKLLQSKG----YPNVEVGSVETYQGRE 624
            .|....:|||    |....|:  :|:|.||.:|.:.:....|.|.    :.::::.:|:.:||:|
pombe  1650 FILLLYERLIQCYLNIDFEGK--IGVVTPYRSQVQQLRSQFQRKYGSIIFKHLDIHTVDGFQGQE 1712

  Fly   625 KTIIIASLVKSFTN--MGFMCNPRRVNVLLSRAKALLILVGNPVTLRHHSDFKFVINECKKHGTY 687
            |.|||.|.|:|..:  :||:.:.||:||.|:|||:.|.:|||...|.....|..:|.:.|..|.:
pombe  1713 KDIIIFSCVRSSMSGGIGFLQDLRRLNVALTRAKSSLYIVGNSKPLMQEDIFYSLIEDAKTRGVW 1777

  Fly   688 ------LLKKRDSGQRPHILIKADESNEESSSEPEDEDDKLIPSYARMQQHTDAAIHKIK----- 741
                  ..|...|.......:.::..|..|...|...     ||....::..:|  ||:|
pombe  1778 RDLSANQFKNSKSISNVSTHLASNNLNLASRDTPIKS-----PSVGICEEKQEA--HKVKKRHNI 1835

  Fly   742 -----AHPTNENDQLANSFKISMSKLS 763
                 :..|..::.:.|  |.:.:|:|
pombe  1836 DSANLSRGTERDEDIPN--KRAKNKVS 1860

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mov10	NP_611185.3	DEXXQc_Helz-like	251..499	CDD:350796	77/350 (22%)
		DNA2	<388..684	CDD:440729	98/358 (27%)
dbl8	NP_596055.1	SEN1_N	75..784	CDD:432746
		TIGR00376	1219..1780	CDD:273041	153/619 (25%)
		AAA_12	1560..1756	CDD:463780	70/216 (32%)