Protein Alignment Mov10 and Helz2

DIOPT Version :10

• Sequence 1: NP_611185.3
• Gene: Mov10 / 36922
• FlyBaseID: FBgn0034187
• Length: 764
• Species: Drosophila melanogaster
• Sequence 2: XP_006500664.1
• Gene: Helz2 / 229003
• MGIID: 2385169
• Length: 2970
• Species: Mus musculus
• Alignment Length: 741
• Identity: 174/741 - (23%)
• Similarity: 280/741 - (37%)
• Gaps: 181/741 - (24%)

  Fly    67 QSDVPVQRVSKLTYKITFKSTPVNAEDFVAPNLDQVVLVPKASL-------------LASPL--- 115
            :.:.|.| |..|.:.:|.:..|   |:.:.|:....|.|....|             .||||
Mouse  2296 RQEAPKQ-VYFLIHHMTMEKVP---EEVLRPSARFTVEVLSKQLPDLRKEEAVRQLKTASPLVIS 2356

  Fly   116 ----------------PKQLVLAL---LPHPHEDL-EPGDPMLRHVASVDKVSSTTVH------V 154
                            |::||..|   :|.|...: ||..||......:.:...:...      .
Mouse  2357 IALGLPIPEIRWPISGPRRLVSELRWPIPGPRRPVSEPHRPMSGPCGPISEPCRSIPEPCRGNWP 2421

  Fly   155 RFSRKHKAVLSGQRFYAIIRSRRLTIRYMYRALNLLQESPLVRRYLFPFPSWLTQLVDNSQIKVC 219
            |....|||  |..||   :..:...|...:..||..|:. .||..|            ..|..|
Mouse  2422 RQHSFHKA--STSRF---LERQNYNIPAGHHKLNQSQDR-AVRSAL------------QKQFTV- 2467

  Fly   220 CDGHLPNWMQGRPQEPATPTSLSLLNSTIYSNAEQLEAVQRIVAGPSTQ----GPYILF-GPPGT 279
                    :||.|....|.....::.....||.||:..    .:.||.:    ||.:|: ||  :
Mouse  2468 --------IQGPPGTGKTVVGFHIVYWFHRSNQEQMPT----DSSPSGEEQLGGPCVLYCGP--S 2518

  Fly   280 GKTTTIVEAILQLRLQQPQSRILVTAGSNSACDTIAL----------KLCEYIESNIRLQE---H 331
            .|:..::..:|..|  :.:.:.|...|..:......|          |..:....|..|:.   |
Mouse  2519 NKSVDVLGGLLLRR--KTEMKPLRVYGEQAEATEFPLPGVSNRSLFGKTSQEGRPNQSLRSITLH 2581

  Fly   332 FAQQKLPEPDHQLIRVYSRSIYEKGFASVPSLLLKNSNCSKSIYDHIKASRIVKYGIIVATLCTV 396
            ...::.|.|....||.:...:.|....|...|.:......|:     :...:.::.:|   |||.
Mouse  2582 HRIRQAPNPYAAEIRKFDAQLREGKIFSKEDLRVYRRVLGKA-----RKHELERHSVI---LCTC 2638

  Fly   397 ARLVTDTLGRYNFFTHIFIDEAGASTEPEALIGIMGIKQTADCHVILSGDHKQLGAVIKSNRAAS 461
            :...:.:|...| ...|.|||||.:||||.||.::...:|.: .|:|.||||||..|:||.:..|
Mouse  2639 SCAASKSLKILN-VRQILIDEAGMATEPETLIPLVCFSKTVE-KVVLLGDHKQLRPVVKSEQLQS 2701

  Fly   462 LGLSRSLMERLLQSDCYKSDENGNYDRNRQMRLCRNYRSHPQIVRLFNELYYNGELKAQAPAMDV 526
            ||:.|||.||              |.|:..| |...||.|..|....:..:|.|:||
Mouse  2702 LGMDRSLFER--------------YHRDAIM-LDTQYRMHKDICSFPSVEFYGGKLK-------- 2743

  Fly   527 NLAANWSVLT----------NPQFPIIFQATHG------VTNREQNSTSSYNNLEAEVICWYVKR 575
                .||.|.          .|...:||.:..|      |:..:.|..|..|..|...:...:|:
Mouse  2744 ----TWSDLRRLPSILGHTGKPSCSVIFGSVQGHEQKLLVSTEDGNENSRANPEEVTQVVRIIKQ 2804

  Fly   576 LINDRVVGQEDVGIVAPYTAQGKLVTKLLQSKGYPNVEVGSVETYQGREKTIIIASLVKSFTN-- 638
            |..||.|..:|:.::.||.||...:::.|..:|...|.|.|:...||.|...:|.|.|::...
Mouse  2805 LTLDRTVDPKDIAVLTPYNAQAAAISRGLMQRGVTGVTVTSITKSQGSEWRYVIVSTVRTCPRSD 2869

  Fly   639 -------------MGFMCNPRRVNVLLSRAKALLILVGNPVTLRHHSDFKFVINECKKHGTYLLK 690
                         :||:.:|.:|||.::||:..|.::|:.:.||....:..:::.|
Mouse  2870 VDQRPTKSWLKKFLGFVVDPHQVNVAITRAQEALCIIGDHLLLRCCPLWHRLLDFC--------- 2925

  Fly   691 KRDSGQRPHILIKADESNEESSSEPE 716
                 :..|.|:.|::.:..:.:..|
Mouse  2926 -----EAQHSLVSAEKCDNPTPNPAE 2946

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mov10	NP_611185.3	DEXXQc_Helz-like	251..499	CDD:350796	70/265 (26%)
		DNA2	<388..684	CDD:440729	96/326 (29%)
Helz2	XP_006500664.1	DEAD-like_helicase_N	760..990	CDD:475120
		AAA_12	961..1161	CDD:463780
		RNB	1567..1924	CDD:214935
		DEXXc_HELZ2-C	2448..2724	CDD:350798	83/330 (25%)
		AAA_12	2704..2909	CDD:463780	60/231 (26%)