Protein Alignment Mov10 and smg-2

DIOPT Version :10

• Sequence 1: NP_611185.3
• Gene: Mov10 / 36922
• FlyBaseID: FBgn0034187
• Length: 764
• Species: Drosophila melanogaster
• Sequence 2: NP_490829.1
• Gene: smg-2 / 171696
• WormBaseID: WBGene00004880
• Length: 1069
• Species: Caenorhabditis elegans
• Alignment Length: 720
• Identity: 189/720 - (26%)
• Similarity: 306/720 - (42%)
• Gaps: 158/720 - (21%)

  Fly   117 KQLVLALLPHPH-----EDLEPGDPM-LRHVASVD-----KVSS-----------TTVHVRFSRK 159
            :|.|||....|.     ..|..||.: |:|..:||     |:.|           ..:.:| ...
 Worm   310 RQSVLAFFHLPQFADGVMKLAKGDELRLKHSQTVDGSEWTKIGSVFKIPDNHGDEVGIEIR-GAV 373

  Fly   160 HKAVLSGQRFYAI-IRSRRLTIRYMYRAL-NLLQESPLVRRYLFPFPSWLTQLVDNSQIKVCCDG 222
            .|:|:..:..:.: :.....|....|:|| .||.:|..:..||:      .:|:.:...::....
 Worm   374 DKSVMESRIMFTVDVVWNATTFERQYKALAALLNDSKAISPYLY------QKLLGHPAEEMMLKF 432

  Fly   223 HLPNWMQ--GRPQEPATPTSLSLLNSTIYSNAEQLEAVQRIVAGPSTQGPYILFGPPGTGKTTTI 285
            .||..:.  |.|:          |||:      |::||::::..|.:    ::.||||||||...
 Worm   433 DLPRRLSVAGLPE----------LNSS------QMQAVKQVLTRPLS----LIQGPPGTGKTVVS 477

  Fly   286 VEAILQLRLQQPQSRILVTAGSNSACDTIALKL----CEYIESNIRLQEHFAQQKLP--EPDHQL 344
            ...:..| :|:.:..:||.:.||.|.|.:|.|:    .:.:....|.:|| ::..:|  ...|||
 Worm   478 ATIVYHL-VQKTEGNVLVCSPSNIAVDHLAEKIHKTGLKVVRLCARSREH-SETTVPYLTLQHQL 540

  Fly   345 IRVYSRSIYEKGFASVPSLL-LKNSNCSKSIYD---HIKASRIVKYGIIVAT---LCTVARLVTD 402
             :|       .|.|.:..|: ||:........|   :::..|:.::.::.|.   .||.:.....
 Worm   541 -KV-------MGGAELQKLIQLKDEAGELEFKDDLRYMQLKRVKEHELLAAADVICCTCSSAADA 597

  Fly   403 TLGRYNFFTHIFIDEAGASTEPEALIGIM-GIKQTADCHVILSGDHKQLGAVIKSNRAASLGLSR 466
            .|.:....| :.|||:..:||||.|:.|| |::|     ::|.|||.|||.|:...:||..|||:
 Worm   598 RLSKIRTRT-VLIDESTQATEPEILVSIMRGVRQ-----LVLVGDHCQLGPVVICKKAAIAGLSQ 656

  Fly   467 SLMERLLQSDCYKSDENGNYDRNRQMRLCRNYRSHPQIVRLFNELYYNGELKAQAPAMDVNLAA- 530
            ||.|||:....            |..||...||.||.:....:.::|:|.|:......|.::..
 Worm   657 SLFERLVLLGI------------RPFRLQVQYRMHPVLSEFPSNVFYDGSLQNGVTENDRHMTGV 709

  Fly   531 --NWSVLTNPQFPIIFQATHGVTNREQNSTSSYNNLEAEVICWYVKRLINDRVVGQEDVGIVAPY 593
              :|   ..|..|..|....|......:.||..|..||..:...|.:||...|...: :|::.||
 Worm   710 DWHW---PKPNKPAFFWHCSGSEELSASGTSFLNRTEAANVEKLVSKLIKAGVQPHQ-IGVITPY 770

  Fly   594 TAQGKLVTKLLQSKG------YPNVEVGSVETYQGREKTIIIASLVKS--FTNMGFMCNPRRVNV 650
            ..|...:...:.::|      |.|||:.||:.:|||||..||.:.|:|  ...:||:.:|||:||
 Worm   771 EGQRSFIVNYMHTQGTLNSKLYENVEIASVDAFQGREKDYIIVTCVRSNDILGIGFLSDPRRLNV 835

  Fly   651 LLSRAKALLILVGNPVTLRHHSDFKFVINECKK--------------------HGTYLLKKRDSG 695
            .::|||..|:||||...|..|..:..:||..|.                    ..|...|...:|
 Worm   836 AITRAKYGLVLVGNAKVLARHDLWHELINHYKSKEMLYEGPINALKPLNLALPKATIRTKNNIAG 900

  Fly   696 QRPHILIKADE--SNEESSSEPEDEDDKLIPSYARMQQHTDAAIHKIKAHPTNENDQLANSFKIS 758
            ......||..:  .||..|::|  ...:|.|:|:..|.                        .:|
 Worm   901 NANRFGIKRMQYTFNEYKSNDP--SQPRLPPTYSNSQN------------------------LLS 939

  Fly   759 MSKLS 763
            ||||:
 Worm   940 MSKLA 944

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mov10	NP_611185.3	DEXXQc_Helz-like	251..499	CDD:350796	75/261 (29%)
		DNA2	<388..684	CDD:440729	100/330 (30%)
smg-2	NP_490829.1	UPF1_Zn_bind	93..243	CDD:401391
		1B_UPF1-like	297..387	CDD:394815	17/77 (22%)
		DEXXQc_UPF1	445..677	CDD:350797	78/279 (28%)
		AAA_12	654..851	CDD:463780	67/212 (32%)