Protein Alignment RhoGEF2 and ARHGEF11

DIOPT Version :10

• Sequence 1: NP_477317.1
• Gene: RhoGEF2 / 36915
• FlyBaseID: FBgn0023172
• Length: 2559
• Species: Drosophila melanogaster
• Sequence 2: XP_006711722.1
• Gene: ARHGEF11 / 9826
• HGNCID: 14580
• Length: 1579
• Species: Homo sapiens
• Alignment Length: 2276
• Identity: 505/2276 - (22%)
• Similarity: 778/2276 - (34%)
• Gaps: 836/2276 - (36%)

  Fly   204 QSDNSNPVLQAPGERSSLNLTPLSRDLSGGHTQESTTPATTPSTPSLALPKNFQYLTLTVRKDSN 268
            ||..|:|:.......|||..:...|.....|.|.|....||.......:          ::||.:
Human    17 QSHLSSPIAAWLSSLSSLGDSAPERKSPSHHRQPSDASETTGLVQRCVI----------IQKDQH 71

  Fly   269 GYGMKVSGDNPVFVESVKPGGAAEIAGLVAGDMILRVNGHEVRLEKHPTVVGLIKASTTVELAVK 333
            |:|..||||..|.|:||:|||||..||:..||.|::|||..|....|..||.|||:...|.|.:.
Human    72 GFGFTVSGDRIVLVQSVRPGGAAMKAGVKEGDRIIKVNGTMVTNSSHLEVVKLIKSGAYVALTLL 136

  Fly   334 RSQKLTRPSSVSV-----------------VTPSTPILSGRDRTASITGPQPVDSIKRREMETYK 381
            .|.    |||:.:                 |.||.|..........||||:|   ::..|::.:.
Human   137 GSS----PSSMGISGLQQDPSPAGAPRITSVIPSPPPPPPLPPPQRITGPKP---LQDPEVQKHA 194

  Fly   382 IQTLQKMLEQEKLNLERLKSDQNNPSYKLSEANIRKLREQLHQVGAEDAPTVKLQAAAGNKNTAL 446
            .|.|:.||.||:..|:|:                                     ....::|.|.
Human   195 TQILRNMLRQEEKELQRI-------------------------------------CEVYSRNPAS 222

  Fly   447 LTPNQIQHLSASATHSNQQFHHLHHHHNLHNNNYPPQQQPASTSPAFLSLLPRSLSSLSLGTRKN 511
            |...||:                                                     |.|:.
Human   223 LLEEQIE-----------------------------------------------------GARRR 234

  Fly   512 KTEKDLTTSSPFGLTTDFLQQQRMSHQAESMSQSMHQHTSTPTSQQFFHPHQQQHRFKETGPTSK 576
            .|:..|......|.:.|.|...                                      |.||
Human   235 VTQLQLKIQQETGGSVDILPLY--------------------------------------GDTS- 260

  Fly   577 GKNKFLISRSLIEEDVPPPLPQRNPPRQLNLDLKNGNASPGGSHLVAPVSDLDRATSPQLNRSQQ 641
                                 ||....:|:||.:.|::.
Human   261 ---------------------QRPSEGRLSLDSQEGDSG-------------------------- 278

  Fly   642 QQLPSSTDNSPSNAKSKRSKIKTKALSDPKMSTQMFLQMESASAAGAAGGSIEVDGGPPPLPPRL 706
              |.|.|:..||.::|..:  :...||||.:.:                             ||
Human   279 --LDSGTERFPSLSESLMN--RNSVLSDPGLDS-----------------------------PR- 309

  Fly   707 PGMMTEDMSRGSCQNLAQPNSVGTAFNYPLVSTTTAVQNDNLNIAFPLSQRPNIVQQLQQYQQQQ 771
                                      ..|::....|
Human   310 --------------------------TSPVIMARVA----------------------------- 319

  Fly   772 QHQMSGGQATGALGQTPNLGKNKHRRVGSSPDNMHPRHPDRITKTTSGSWEIVEKDGESSPPGTP 836
            ||                     |||.||.                    ..|...|:.....:|
Human   320 QH---------------------HRRQGSD--------------------AAVPSTGDQGVDQSP 343

  Fly   837 PPPYLSSSHMTVLEDPNENNRGAAAAGPGVFIESHQFTPMAGASSPIPISLHSSHMHAAQSNDTQ 901
            .|         ::..|.|:      ..||.|                               :.:
Human   344 KP---------LIIGPEED------YDPGYF-------------------------------NNE 362

  Fly   902 KEIISMEDENSDLDEPFIDENGPFNNLTRLLEAENVTFLAIFLNYVISNSDPAPLLFYLITELYK 966
            .:||                   |.:|.:|  ......|.:||.|:.|.:||:||||||..|:|:
Human   363 SDII-------------------FQDLEKL--KSRPAHLGVFLRYIFSQADPSPLLFYLCAEVYQ 406

  Fly   967 EGTSKDMRKWAYEIHSTFLVPRAPLSWYRQDESLAREVDNVLQLEYDKVEILRTVFLRSRKRAKD 1031
            :.:.||.|....:|.:.||...|||. .:..|.|..|:|:.|:...|    .|.|...:::.|..
Human   407 QASPKDSRSLGKDIWNIFLEKNAPLR-VKIPEMLQAEIDSRLRNSED----ARGVLCEAQEAAMP 466

  Fly  1032 LISEQLREFQQKRTAGLGTIYGPTDDKLAEAKTDKLRE-QIIDKYL--MPNLHALIEDENGSPPE 1093
            .|.||:.:::.|||.|||::||..|  |.:...|.||| |:.:|.|  :.::.:..|::..:|.:
Human   467 EIQEQIHDYRTKRTLGLGSLYGEND--LLDLDGDPLRERQVAEKQLAALGDILSKYEEDRSAPMD 529

  Fly  1094 DVRKVALCSALSTVIYRIFNTRPPPSSIVERVHHFVSRDKSFKSRIMGKNRKMNVRGHPLVLRQY 1158
                .||.:.:|....|:...|  ||:..|:......:||
Human   530 ----FALNTYMSHAGIRLREAR--PSNTAEKAQSAPDKDK------------------------- 563

  Fly  1159 YEVTHCNHCQTIIWGVSPQGYHCTDCKLNIHRQCSKVVDESCPGPLPQAKRLAHNDKISKFMGKI 1223
                         |                           .|. .|:.|:.:.|.|..|
Human   564 -------------W---------------------------LPF-FPKTKKQSSNSKKEK----- 582

  Fly  1224 RPRTSDVIGNEKRSRQDEELDVELTPDRGQASIVRQPSDRRPDANISIRSNGNTSCNTSGLNTTD 1288
                 |.:.::||                                       |......|...:.
Human   583 -----DALEDKKR---------------------------------------NPILKYIGKPKSS 603

  Fly  1289 LQSSFHGSCANDSINPGGGAGCNMDLSTSVASTTPSTSGSVAAGLSAFAELNALDTVDKEARRER 1353
            .||:||...:...:.||...........:.....|. .|:......:|.|    |.::.::.|
Human   604 SQSTFHIPLSPVEVKPGNVRNIIQHFENNQQYDAPE-PGTQRLSTGSFPE----DLLESDSSR-- 661

  Fly  1354 YSQHPKHKSAPVSVNRSESYKERLSNKRNR---NSRRKTSDPSLSSRPNDEQLDLGLSNATYVGS 1415
                     :.:.:.||||.|.|...||:|   |..|..||..:.:.....:|....|      |
Human   662 ---------SEIRLGRSESLKGREEMKRSRKAENVPRSRSDVDMDAAAEATRLHQSAS------S 711

  Fly  1416 SNSSLSSAGGSESPSTSMEHFAAPGAAGGVQVPPMGL-NQNQHPHLLIQQHAQQYCQQDSFQAGL 1479
            |.||||:. ..|:|:..   |........::.|.:|. .....||||         :.|..|.
Human   712 STSSLSTR-SLENPTPP---FTPKMGRRSIESPSLGFCTDTLLPHLL---------EDDLGQL-- 761

  Fly  1480 AGAAGSSAASNSSFWNAGHPLPVARWTLESEDEDDVNEADWSSMVAAEVLAALTDAEKKRQEIIN 1544
                                         |:.|.:.:..:|...|..:|:|.||..|..|||:||
Human   762 -----------------------------SDLEPEPDAQNWQHTVGKDVVAGLTQREIDRQEVIN 797

  Fly  1545 EIYQTERNHVRTLKLLDRLFFLPLYESGLLSQDHLLLLFP--PALLSLREIHGAFEQSLKQRRIE 1607
            |::.||.:|:|||::||.:|:..:.:..|:.::.|..|||  |.|:   |||.::.:::|:.| |
Human   798 ELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFPNLPELI---EIHNSWCEAMKKLR-E 858

  Fly  1608 HNHVVNTIGDLLADMFDGQSGVVLCEFAAQFCARQQIALEALKEKRNKDEMLQKLLKKSESHKAC 1672
            ...::..|.||:...|||.:...|.:.|||||:.|.||||.:|.|:.|:...|..::::|||..|
Human   859 EGPIIKEISDLMLARFDGPAREELQQVAAQFCSYQSIALELIKTKQRKESRFQLFMQEAESHPQC 923

  Fly  1673 RRLELKDLLPTVLQRLTKYPLLFENLYKVTVRLLPENTTEAEAIQRAVESSKRILVEVNQAVKTA 1737
            |||:|:||:.:.:|||||||||.|::.|.|    ...|:|.|.:.||.:..:.||..||:|||..
Human   924 RRLQLRDLIISEMQRLTKYPLLLESIIKHT----EGGTSEHEKLCRARDQCREILKYVNEAVKQT 984

  Fly  1738 EDAHKLQNIQRKLDRSSYDK------EEFKKLDLTQHHLIHDGNLT--IKKNPSVQLHGLLFENM 1794
            |:.|:|:..|::||.::.::      .|||.||||...:||:|.||  |.|:.::.||.||.|::
Human   985 ENRHRLEGYQKRLDATALERASNPLAAEFKSLDLTTRKMIHEGPLTWRISKDKTLDLHVLLLEDL 1049

  Fly  1795 IVLLTKQDDKYYLKNLHTPLSI----TNKPVSPIMSIDADTLIRQEAADKNSFFLI---KMKTSQ 1852
            :|||.|||:|..|| .|:..::    :.:..||::.::| .|||..|.||.:||:|   |:...|
Human  1050 LVLLQKQDEKLLLK-CHSKTAVGSSDSKQTFSPVLKLNA-VLIRSVATDKRAFFIICTSKLGPPQ 1112

  Fly  1853 MLELRAPSSSECKTWFKHFSDVAARQSKNRSKNASSNHDTSISDPALAAIPHSNTKESLELSTDT 1917
            :.||.|.:||:..||.:...:..        :||:.:       |..|.:|
Human  1113 IYELVALTSSDKNTWMELLEEAV--------RNATRH-------PGAAPMP-------------- 1148

  Fly  1918 VQPLAATATLTTTPLAPMLPIATVTPAPA---TNNSNV-------SSLTG-------------VQ 1959
            |.|         .|..|..| |...|.|:   .::|:|       ..|.|             |.
Human  1149 VHP---------PPPGPREP-AQQGPTPSRVELDDSDVFHGEPEPEELPGGTGSQQRVQGKHQVL 1203

  Fly  1960 LRNPQRDATASESDADYVNTPKPRSSQNEVNRTMSIRS------TGEPIQKYSANGTEANDVTLR 2018
            |.:|:::.:|.|.:...:  |.|.:|.:..||.:..|:      .|....:..|:....:...||
Human  1204 LEDPEQEGSAEEEELGVL--PCPSTSLDGENRGIRTRNPIHLAFPGPLFMEGLADSALEDVENLR 1266

  Fly  2019 HSQSTRESVRPGSTGEERNSTYGMVGGNSKRDSASIVCSNNSNNTRTLLMQSPLVD----PTAIQ 2079
            |  ....|:.||.|.|                              |...|.|..|    |:.|.
Human  1267 H--LILWSLLPGHTME------------------------------TQAAQEPEDDLTPTPSVIS 1299

  Fly  2080 VSISPAHTAEPVLTP--GEKLRRLDASIRNDLLEKQKI-ICDIFRLPVEHYDQIVDIAMMPEAPK 2141
            |:..|.....|...|  ||......|.:..:..|::.: :|.:..||....:.  .|...||..:
Human  1300 VTSHPWDPGSPGQAPPGGEGDNTQLAGLEGERPEQEDMGLCSLEHLPPRTRNS--GIWESPELDR 1362

  Fly  2142 D-----SADIALAAYDQIQTLTKMLNEYMHVTPEQ--------EVSAVSTAVCGHCHEKEKLRKK 2193
            :     |:..|...|..::......::.:...||.        ||.. .|...|:|....  ...
Human  1363 NLAEDASSTEAAGGYKVVRKAEVAGSKVVPALPESGQSEPGPPEVEG-GTKATGNCFYVS--MPS 1424

  Fly  2194 VAPSSSFSSSPPPLPPPNRQ-----HAQAQAQIP--------PSRLMPKLQTLDLDEVAIHEDDD 2245
            ..|.||...|..|:.||...     ..:.|.|:.        |||..|.|...|:..:
Human  1425 GPPDSSTDHSEAPMSPPQPDSLPAGQTEPQPQLQGGNDDPRRPSRSPPSLALRDVGMI------- 1482

  Fly  2246 GYCEIDELRLPAIPSKPHERP---------------TTPLAPFNTEPK--TSQSVIDASKRQSTD 2293
             :..|::|.|.....|..|..               |||:..|:||..  |..|:...:|
Human  1483 -FHTIEQLTLKLNRLKDMELAHRELLKSLGGESSGGTTPVGSFHTEAARWTDGSLSPPAK----- 1541

  Fly  2294 AVPEGLLEQEPLEGDKTETKGEDNEVKTVPSDKLSESCNEERQCVEADITKEVADPTTSKNEAAA 2358
                     |||..|                   |.:.:|...|.|......:.|.|.   :|||
Human  1542 ---------EPLASD-------------------SRNSHELGPCPEDGSDAPLEDSTA---DAAA 1575

  Fly  2359 S 2359
            |
Human  1576 S 1576

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF2	NP_477317.1	PDZ_ARHGEF11-12-like	258..333	CDD:467282	34/74 (46%)
		RGS_GEF_like	934..1055	CDD:188710	44/120 (37%)
		C1_ARHGEF-like	1150..1202	CDD:410382	1/51 (2%)
		RhoGEF	1539..1731	CDD:238091	78/193 (40%)
		PH_16	1756..1876	CDD:436083	50/134 (37%)
ARHGEF11	XP_006711722.1	PDZ_ARHGEF11-12-like	61..136	CDD:467282	34/84 (40%)
		RGS_PDZRhoGEF	346..490	CDD:188707	54/206 (26%)
		RhoGEF	792..978	CDD:238091	78/193 (40%)
		PH_PRG	996..1138	CDD:275426	52/151 (34%)
		PHA03307	1229..>1579	CDD:223039	86/429 (20%)