Protein Alignment RhoGEF2 and Arhgef1

DIOPT Version :10

• Sequence 1: NP_477317.1
• Gene: RhoGEF2 / 36915
• FlyBaseID: FBgn0023172
• Length: 2559
• Species: Drosophila melanogaster
• Sequence 2: NP_001427061.1
• Gene: Arhgef1 / 60323
• RGDID: 620951
• Length: 975
• Species: Rattus norvegicus
• Alignment Length: 1255
• Identity: 306/1255 - (24%)
• Similarity: 485/1255 - (38%)
• Gaps: 356/1255 - (28%)

  Fly   858 GAAAAGPGVFIESHQFTPMAGASSPIPISLHSSHMHAAQSNDTQKEIISMEDEN--SDLDEPFID 920
            |.||.||          |.:|.     :|:                ||..|||:  ::|:....|
  Rat     6 GGAAPGP----------PRSGL-----VSI----------------IIGAEDEDFENELEANPED 39

  Fly   921 ENGPFNNLTRLLEAENVTFLAIFLNYVISNSDPAPLLFYLITELYKEGTSKDMRKWAYEIHSTFL 985
            :|..|.:|.::  ......|...|.:|....:|.|||..|..::......|:.:|...:.:.:||
  Rat    40 QNSQFQSLEQV--KRRPAHLMALLQHVALQFEPGPLLCCLHADMLSSLGPKEAKKAFLDFYHSFL 102

  Fly   986 ----VPRAPLSWYRQDESLAREVDNV---LQLEYDKVEILRTVFLRSRKRAKDLISEQLREFQQK 1043
                |.|.|:     ..|:|.|:|..   |..|..:...::.| ::|::.|   ::.||.:|:.|
  Rat   103 EKTAVLRVPV-----PPSVAFELDRTRPDLISEDVQRRFIQEV-VQSQQAA---VTRQLEDFRSK 158

  Fly  1044 RTAGLGTIYGPTDDKLA-------------EAKTDKLREQIIDKYLMPNLHALIEDENGSPPEDV 1095
            |..|:    .|.:.:|:             ||:...:.|::: .:|....|.:..||.
  Rat   159 RLMGM----TPWEQELSLLEPWIGKDRGNYEARERHVAERLL-SHLEEMQHTISTDEE------- 211

  Fly  1096 RKVALCSALSTVIYRIFNTRPPPSSIVERVHHFVSRDKS---------FKSRIMGKNRKMNVRGH 1151
            :..|:.:|:|  :|               :.|...|.||         |:.::||..|.
  Rat   212 KSAAVVTAIS--LY---------------MRHLGVRTKSGDKKSGRNFFRKKVMGNRRS------ 253

  Fly  1152 PLVLRQYYEVTHCNHCQTIIWGVSPQGYHCTDCKLNIHRQCSKVVDESCPGPLPQAKRLAHNDKI 1216
                                                         ||.     |:.|:     .:
  Rat   254 ---------------------------------------------DEP-----PKTKK-----GL 263

  Fly  1217 SKFMGKIR-----PRTSDVIGNEKRSRQDEELDVELTPDRGQASIVRQPSDRRPDANISIRSNGN 1276
            |..:...|     |...|.          ..|.||:....|       |:||:....||.|   :
  Rat   264 SSILDPARWNRGEPSAPDC----------RHLKVEVDEKPG-------PADRKGSLGISSR---D 308

  Fly  1277 TSCNTSGLNTTDLQSSFHGSCAN--DSINPGGGAGCNMDLSTSVASTTPSTSGSVAAGLSAFAEL 1339
            .:..|.|.:...:  |.|....:  ||..||      :|.......|.|.       |.::...|
  Rat   309 RTVGTPGQDNPGV--SLHPLSVDSLDSREPG------VDTPQEPGDTPPQ-------GPTSLEPL 358

  Fly  1340 NALDTVDKEARRERYSQHPKHKSAPVSVNRSESYKERLSNKRNRNSRRKTSDPSLSSRPNDEQLD 1404
                                   ||..........||||.:..|:...:.||....||
  Rat   359 -----------------------APPESTEDNGETERLSGRLGRSESLRVSDRRRPSR------- 393

  Fly  1405 LGLSNATYVGSSNSSLSSAGGSESPSTSMEHFAAPGAAGGVQVPPMGLNQNQHPHLLIQQHAQQY 1469
                      .|..:....||.......|:    ||:|..|    :|..:...|
  Rat   394 ----------GSLGAKGRGGGRSRSDVDMD----PGSATAV----LGPTRRATP----------- 429

  Fly  1470 CQQDSFQAGLAGAAGSSAASNSSFWNAGHPLPVARWTLESEDEDDVNEADWSSMVAAEVLAALTD 1534
                  :.|..|..|.|.                   ||.|.|:   ...|..:|.::.|..|..
  Rat   430 ------EPGDDGEPGRSG-------------------LEQEPEE---PPGWRELVPSDTLLGLPK 466

  Fly  1535 AEKKRQEIINEIYQTERNHVRTLKLLDRLFFLPLYESGLLSQDHLLLLFPPALLSLREIHGAFEQ 1599
            .:.||||:|:|:..||..|||.|::|..||:.|:.|.|....:.|..:| |:|..|.|:|..|..
  Rat   467 NQVKRQEVISELLVTEAAHVRMLRVLHDLFYQPMAEGGFFPLEELQNIF-PSLDELIEVHSLFLD 530

  Fly  1600 SLKQRRIEHNHVVNTIGDLLADMFDGQSGVVLCEFAAQFCARQQIALEALKEKRNKDEMLQKLLK 1664
            .|.:||.|..:::..|||:|...|||..|....:.:::||:||..|||.||.|:.|:......::
  Rat   531 RLMKRRQESGYLIEEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALEQLKAKQRKEPRFCAFVQ 595

  Fly  1665 KSESHKACRRLELKDLLPTVLQRLTKYPLLFENLYKVTVRLLPENTTEAEAIQRAVESSKRILVE 1729
            ::||...||||:|||::||.:|||||||||.:::.:.|     |...|...::.|.|..:.||..
  Rat   596 EAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNT-----EEPAERAKVELAAECCREILHH 655

  Fly  1730 VNQAVKTAEDAHKLQNIQRKLD----RSSYDK--EEFKKLDLTQHHLIHDGNLT--IKKNPSVQL 1786
            |||||:..||..:|::.||:||    |.|.|.  .|||.||:|:..|:|:|.||  :.|:.:|::
  Rat   656 VNQAVRDMEDLLRLKDYQRRLDLTHLRQSNDPMLSEFKNLDITKKKLVHEGPLTWRLTKDKAVEV 720

  Fly  1787 HGLLFENMIVLLTKQDDKYYLKNLH----TPLSITNKPVSPIMSIDADTLIRQEAADKNSFFLIK 1847
            |.||.:::::||.:||::..||: |    ||.......:.|::.: ...:.|:.|.|..:|::|.
  Rat   721 HVLLLDDLLLLLQRQDERLLLKS-HSRTLTPTPDGKTMLRPVLRL-TSAMTREVATDHKAFYVIF 783

  Fly  1848 M--KTSQMLELRAPSSSECKTWFKHFSDVAARQSKNRSKNASSNHDTSISDPALAAIPH-----S 1905
            .  :.:|:.||.|.:|||.|:|....::.|.                |:..||.|:.|.     |
  Rat   784 TWDQEAQIYELVAQTSSERKSWCALITETAG----------------SLKVPAPASRPKPRPSPS 832

  Fly  1906 NTKESL----ELSTDTVQPLAATATLTTTPLAPMLPIATVTPAP-----ATNNSNVSSLTGVQLR 1961
            :|:|.|    |..|...:...|.|. |...|..:||..  .|.|     ||....|.||..:.|.
  Rat   833 STREPLLSSSENGTGGTEAAPADAR-TERILNDLLPFC--RPGPEGQLAATALQKVLSLKQILLS 894

  Fly  1962 NPQRDATASESDADYV---NTPKPRSSQNEVNRTMSIRSTGEPIQKYSANGTEANDVTLRHSQS- 2022
            ..:........|.|.|   ..|.|..:|......:|:....:.:::     .|.....||...|
  Rat   895 TEEDSGAGPPRDGDGVPGGGAPGPTHTQEVEENLLSLEVVIKQLEE-----LEEEFCRLRPFLSQ 954

  Fly  2023 TRESVRPGSTGEERNSTYGM 2042
            ..|.:.|.....||::..|:
  Rat   955 LGEILSPNLAAPERSAQTGL 974

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF2	NP_477317.1	PDZ_ARHGEF11-12-like	258..333	CDD:467282
		RGS_GEF_like	934..1055	CDD:188710	30/127 (24%)
		C1_ARHGEF-like	1150..1202	CDD:410382	2/51 (4%)
		RhoGEF	1539..1731	CDD:238091	75/191 (39%)
		PH_16	1756..1876	CDD:436083	41/129 (32%)
Arhgef1	NP_001427061.1	None