Protein Alignment RhoGEF2 and Arhgef18

DIOPT Version :10

• Sequence 1: NP_477317.1
• Gene: RhoGEF2 / 36915
• FlyBaseID: FBgn0023172
• Length: 2559
• Species: Drosophila melanogaster
• Sequence 2: XP_063127313.1
• Gene: Arhgef18 / 304193
• RGDID: 1311448
• Length: 1396
• Species: Rattus norvegicus
• Alignment Length: 1475
• Identity: 310/1475 - (21%)
• Similarity: 525/1475 - (35%)
• Gaps: 400/1475 - (27%)

  Fly  1181 CTDCKLNIHRQCSKVVDESCPGPLPQ-----AKRLAHNDKISKFMGKI----RPRTSDVIGN--E 1234
            |::....:....|:|.:.:|   ||:     |..|:.:.:.:...|.:    .|..|...||  |
  Rat   115 CSERGRRLSLDASEVDEGAC---LPRTLASLALNLSGDGQKTWIQGCLPVSGTPAPSSKEGNSPE 176

  Fly  1235 KRSRQD------EEL---------DVELTPDRGQASIVRQPSDR---RPDANISIRSNGNTSCNT 1281
            ||.|..      ||:         ||...|.:|....|.:..::   .||..:.::.
  Rat   177 KRLRSKSVPVSCEEISCLEPASGSDVCAPPVQGLEPPVLECLEKDHVEPDHVLIVQQ-------- 233

  Fly  1282 SGLNTTDLQS--SFHGS--CANDSINPGGGAGCNMDLSTSVASTTPSTSGSVAAGLSAFAELNAL 1342
                  .||.  .:||:  .|..||:|||                |.::      |:.|..|:
  Rat   234 ------VLQELRQYHGARQRARMSISPGG----------------PHSN------LTWFEFLS-- 268

  Fly  1343 DTVDKEARRERYSQHPKHKSAPVSVNRSESYKERLSNKRNRNSRRKTSD-------------PSL 1394
            ::.|...:.|:             .::|...|..||:.|:|.:|:|...             |..
  Rat   269 ESEDGVCKNEK-------------TDKSTRVKRSLSSLRSRVTRQKEKGKNPAHLKDKIQDVPGK 320

  Fly  1395 SSRPNDEQLDLG---------------LSNATYVGSSNSSLSSAGGSESPSTSMEHFAA------ 1438
            ....|..||..|               ||:|:......::|.|.|.|.:||.::....:
  Rat   321 RECVNGHQLVRGTFSGHSSCPLCGKPLLSSASLKEHPRTALLSDGSSPAPSRNVGMTVSQKGGLQ 385

  Fly  1439 --PGAAG-GVQVPPMG--LNQNQHPHLLIQQHAQQYCQQDSFQAGLAGAAGSSAASNSSFWNAGH 1498
              |..|| ||::.|:.  :::.....|.::|.|     .||.         |..:||:.......
  Rat   386 PTPSPAGSGVRLGPIAGDMDEADSVFLKLKQTA-----DDSL---------SLTSSNAESVFIED 436

  Fly  1499 PLPVARWTLESEDEDDVNEAD---WSSMVAAEVLAALTDAEK--KRQEIINEIYQTERNHVRTLK 1558
            |...   :|..|.|.|.:|.:   ||  ::.:|..|....::  |||:::.|:.|||.:||||||
  Rat   437 PYTA---SLRCEIESDAHEFEAESWS--LSVDVAYAKKQKKEVVKRQDVLYELMQTEAHHVRTLK 496

  Fly  1559 LLDRLFFLPLYESGLLSQDHLLLLFPPALLSLREIHGAFEQSLKQRRIE-------HNHVVNTIG 1616
            ::.:::...|.|....|...:..|||.| ..|.::|..|...||:||.|       .|:|:..||
  Rat   497 IMLKVYSRALQEELQFSVQAVSRLFPCA-DDLLDMHSHFLARLKERRQEFLEEDSDRNYVIQKIG 560

  Fly  1617 DLLADMFDGQSGVVLCEFAAQFCARQQIALEALKEKRNKDEMLQKLLKKSESHKACRRLELKDLL 1681
            |:|...|.|::|..:.|....||:..:.|:...|....:.:..|.|:||..:....|||.:::.:
  Rat   561 DVLVQQFSGETGERMKEKYGVFCSGHKDAVGHYKLLLQQSKKFQNLIKKIGNFSIVRRLGVQECI 625

  Fly  1682 PTVLQRLTKYPLLFENLYKVTVRLLPENTTEAEAIQRAVESSKRILVEVNQAVKTAEDAHKLQNI 1746
            ..|.||:||||:|.|.:.:.|    ...|.:.:.:.:|:...|.|:.:|:..|...|...:|:.|
  Rat   626 LLVTQRITKYPVLVERIIQNT----EAGTEDYKDLSQALNLIKDIISQVDAKVSECEKDQRLKEI 686

  Fly  1747 QRKLDRSSYDK----EEFKKLDLTQHHLIHDGNLTIKKNPS--VQLHGLLFENMIVLLTKQDDKY 1805
            ..|:|..|..|    ..|:|.|:.|..|..|..|..|....  ..:..:|..::::||.::|.||
  Rat   687 VAKMDSKSSGKLKNGRTFRKEDMLQRQLHLDSTLCWKSTSGRLKDVLAVLLTDVLLLLQEKDQKY 751

  Fly  1806 YLKNLHTPLSITNKPVSPIMSIDADTLIRQEAADKNSFFLI--KMKTSQMLELRAPSSSECKTWF 1868
            ..      .|:.:||  |::|:. ..::|:.|.::.:.|||  .|:..:|.|:...|..:...|.
  Rat   752 VF------ASVDSKP--PVISLQ-KLIVREVANEEKAMFLISASMQGPEMYEIYTSSKEDRNIWM 807

  Fly  1869 KHFSDVAARQSKNRSKNASSNHDTSISDPALAAIPHSNTKESLELSTDTVQPLAATATLTTTPLA 1933
            .|.         .|:..:..:.:..|       ...:..:...|..|..::......:|....:|
  Rat   808 AHI---------RRAVESCPDEEEGI-------FLEAEERRMAEARTMKLRDFQERLSLKDQLIA 856

  Fly  1934 PMLPIATVTPAPATNNSNVSSLTGVQLRNPQRDATASESDADYVNTPKPRSSQNEVNRTMSIRST 1998
            ..|                  |...|:.......:..:..|......:.....:|..|
  Rat   857 QSL------------------LEKQQIYLEMAQLSGLDESAQCRGLFRGGGDPSETLR------- 896

  Fly  1999 GEPIQKYSANGTEA-NDVTLRHSQSTRESVRPG--STGEERNST----YGMVGGNSKRDSASIVC 2056
            ||.|.:.:.:..|. ..:..||..||...|..|  |.|..|.:.    |..||..:|..|.....
  Rat   897 GEQILRSAMSEIEGIQSLICRHVGSTSSQVEEGGVSAGLPRRAETFGGYDSVGSPNKGGSFKRKV 961

  Fly  2057 SNNSNNTRTLLMQSPLVDPTAIQVSISPAHTAEPVLTPGEKLRRLDASIRNDLLEKQKIICDIFR 2121
            .|  ::.|....|.|...|.::     |..|..|                       ...|
  Rat   962 YN--SDPRPQDWQGPASSPDSM-----PCDTTTP-----------------------SGCC---- 992

  Fly  2122 LPVEHYDQIVDIAMMPEAPKDSADIALAAYDQIQTLTKMLNEYMHVTPEQEVSAVSTAVCGHCHE 2186
               |...|.|::.....:|.....:......::|||:::|.....|..:|:.......:.....|
  Rat   993 ---EESPQAVEMPSAESSPCLPTVLESELVHRVQTLSQLLLSLQAVIAQQDSYVEMQRMAIQERE 1054

  Fly  2187 K---------------------EKLRKKVAPSSSFSS---SPPPLPPPNRQHAQAQAQIPPSRLM 2227
            |                     ||.|::.|......:   .........|...|.:.::..:||.
  Rat  1055 KQFRLQSTRGNLLLEQERQRNFEKQREERAGVEKLQNQLRQEQQRWERERARQQQELELAGARLQ 1119

  Fly  2228 PK-------LQTLDLDEVAIHEDDDGY-CEIDELRLPAIPSKPHERPTTPLAPFNTEPKTSQSVI 2284
            .:       .|.||.:...:......| .:::.|| .|..:...||....|             :
  Rat  1120 EREGEARQLRQRLDQERTELERQRQAYQHDLERLR-EAQRAVDRERERLEL-------------L 1170

  Fly  2285 DASKRQST---DAVPEGLLEQEP-----------LEGDKTETK----------------GEDNEV 2319
            ...|:|:|   ...||.|.|.:|           |||.....|                ||..||
  Rat  1171 RRFKKQNTVPGALPPEVLAEAQPASHPLNFNGDGLEGHLAPAKAPGTQGSMLHGTGPEYGERAEV 1235

  Fly  2320 --------------KTVPSDKLSESCNEERQ-CVEADITKEVADPT------TSKN------EAA 2357
                          ..||...||.:...:|| .|:..|..::|..|      .||:      |::
  Rat  1236 ARWDSAPAESRPAKSDVPIQLLSATNQIQRQTAVQQQIPTKLAASTKGGKDKNSKSRGSQRWESS 1300

  Fly  2358 ASVD--ELPSQSREIKTAENASKSVADKKEDNEETIE------EGVASTVD---SSTQTSPTESP 2411
            ||.|  :.|..::.:...||||:        |..::.      .|.|...|   .:....|..:.
  Rat  1301 ASFDLKQQPLFNKLMGKDENASR--------NRRSLSPVLPAAHGSAPAPDPCFPAPSPVPAATA 1357

  Fly  2412 KETDKLTGGSSSTCGPNRIQHASVLEPSVPCHALSSIVTILNEQI 2456
            .|..| :||:|             |.|:.|..:|.:....:.:::
  Rat  1358 PEAFK-SGGTS-------------LPPASPAPSLPTTPPTITDEV 1388

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF2	NP_477317.1	PDZ_ARHGEF11-12-like	258..333	CDD:467282
		RGS_GEF_like	934..1055	CDD:188710
		C1_ARHGEF-like	1150..1202	CDD:410382	4/20 (20%)
		RhoGEF	1539..1731	CDD:238091	62/198 (31%)
		PH_16	1756..1876	CDD:436083	31/127 (24%)
Arhgef18	XP_063127313.1	None