Protein Alignment RhoGEF2 and Arhgef3

DIOPT Version :10

• Sequence 1: NP_477317.1
• Gene: RhoGEF2 / 36915
• FlyBaseID: FBgn0023172
• Length: 2559
• Species: Drosophila melanogaster
• Sequence 2: NP_001423677.1
• Gene: Arhgef3 / 290541
• RGDID: 1310672
• Length: 551
• Species: Rattus norvegicus
• Alignment Length: 520
• Identity: 116/520 - (22%)
• Similarity: 191/520 - (36%)
• Gaps: 135/520 - (25%)

  Fly  1492 SFWNAGHP--LPVARWTLESEDEDDVNEAD---WSSMVAAEVLAALTDAEKKRQEIINEIYQTER 1551
            ||.|...|  |....|: .:.........|   ||......|...||..|.||||.|.|:.|.|.
  Rat    98 SFRNESRPDILAPRAWS-RNATSSSTKRRDSKLWSETFDVCVSQVLTAKEIKRQEAIFELSQGEE 161

  Fly  1552 NHVRTLKLLDRLFFLPLYESGLLSQDHLLLLFPPALLSLREIHGAFEQSLKQRR--------IEH 1608
            :.:..|||..:.:..|:.:..::::..|..:| ..|.||..:|   |..|.|.|        .||
  Rat   162 DLIEDLKLAKKAYHDPMLKLSIMTEQELNQIF-GTLDSLIPLH---EDLLSQLRDVRKPDGSTEH 222

  Fly  1609 NHVVNTIGDLLADMFDGQSGVVLCEFAAQFCARQQIALEALKEKRNKDEMLQKLLKKSESHKACR 1673
                  :|.:|.       |.:.|..:.......|:|.:||.:.:.:|..:|..|::.......|
  Rat   223 ------VGPILV-------GWLPCLSSYDSYCSNQVAAKALLDHKKQDHRVQDFLQRCLESPFSR 274

  Fly  1674 RLELKDLLPTVLQRLTKYPLLFENLYKVTVRLLPENTTEAEAIQRAVESSKRILVEVNQAVKTAE 1738
            :|:|.:.|.....||.|||||...:.:.|    |.:..:.:.::.|:...:.|:.|:|  .||.|
  Rat   275 KLDLWNFLDIPRSRLVKYPLLLREILRHT----PNDNPDQQHLEEAINIIQGIVAEIN--TKTGE 333

  Fly  1739 DAHKLQNIQRKLDRSSYDKEEFKKLDLTQHHLIHDGNLT------IKKNPSVQLHGLLFENMIVL 1797
                        ....|.||....|:..|...:.|.:..      :|.|..|:||..||:.::|:
  Rat   334 ------------SECRYYKERLLYLEEGQKDSLIDSSRVLCCHGELKNNRGVKLHVFLFQEVLVI 386

  Fly  1798 ---LTKQDDKYYLKNLHTPLSITNKPVSPIMSIDADTLIRQE---------AADKN----SFFLI 1846
               :|..:...|        .:..:|: |:..:..:.|...|         |...|    :||.:
  Rat   387 TRAVTHNEQLCY--------QLYRQPI-PVKDLTLEDLQDGEVRLGGSLRGAFSNNERIKNFFRV 442

  Fly  1847 KMKT---SQMLELRAPSSSECKTWFKHFSDVAARQSKNRSKNASSNHDTSISDPALAAIPHSNTK 1908
            ..|.   ||...|:|..:...:.|..     ..||:|
  Rat   443 SFKNGSQSQTHSLQANDTFNKQQWLN-----CIRQAK---------------------------- 474

  Fly  1909 ESLELSTDTVQPLAATATLTTTPLAPMLPIATVTPAPATNNSNVSSLTGVQLRNPQRDATASESD 1973
                   :||        |:....|.:|...:::.:|.|.|..:...|.::    |.|.:.||||
  Rat   475 -------ETV--------LSAAGQAGLLDSESLSQSPGTENRELRGETKLE----QMDQSDSESD 520

  Fly  1974  1973
              Rat   521  520

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF2	NP_477317.1	PDZ_ARHGEF11-12-like	258..333	CDD:467282
		RGS_GEF_like	934..1055	CDD:188710
		C1_ARHGEF-like	1150..1202	CDD:410382
		RhoGEF	1539..1731	CDD:238091	50/199 (25%)
		PH_16	1756..1876	CDD:436083	29/144 (20%)
Arhgef3	NP_001423677.1	RhoGEF	152..328	CDD:459876	47/196 (24%)
		PH_RhoGEF3_XPLN	342..474	CDD:269976	29/145 (20%)