Protein Alignment RhoGEF2 and rgf1

DIOPT Version :10

• Sequence 1: NP_477317.1
• Gene: RhoGEF2 / 36915
• FlyBaseID: FBgn0023172
• Length: 2559
• Species: Drosophila melanogaster
• Sequence 2: NP_588116.1
• Gene: rgf1 / 2539580
• PomBaseID: SPCC645.07
• Length: 1334
• Species: Schizosaccharomyces pombe
• Alignment Length: 1080
• Identity: 210/1080 - (19%)
• Similarity: 351/1080 - (32%)
• Gaps: 323/1080 - (29%)

  Fly  1109 YRIFNTRPPPS------------SIVERVHHFVSRDKSFKSRIMGKNRKMNVRGHPLVLR----- 1156
            :|..:.:||.|            |.|:.:.|    .:||.|.....|....|   ||.|:
pombe    64 FRSTSLQPPSSQPPAPPTHQREASPVKNIEH----SESFPSVFGTSNNHQIV---PLTLKDGNDF 121

  Fly  1157 -----------QYYEVTHCNHC------QTIIWGVSPQGYHCTDCKLNIHRQ-------CSKVVD 1197
                       .:.:|:  ||.      .::.|..| .|.........:.||       .|..||
pombe   122 GALYASLNTTPHFPQVS--NHAPNNSNSPSLTWHTS-SGDDSNQNPFFVRRQSQSSTSPVSDSVD 183

  Fly  1198 ESCPGPLPQAKRLA----HNDKISKFMGKIRPRTSDVIGNEKRSRQDEE---------------- 1242
            |:....:.......    |.|:...:...:|...:..:.:..|...|:.
pombe   184 ENLLSAVSSVTESVETNLHLDQNYPYGSPVRSSKNPFLSSNSRLPTDDSSHTVGSHSFTSGTHPP 248

  Fly  1243 ---------LDVELTPDRGQASIVRQ----PSDRRPDANISIRSNGNTSCNTSGLNTTDLQSSFH 1294
                     |...:|| ..||.::|.    |::..|.|. |::...:||
pombe   249 IVSSNSAFTLPNAVTP-AAQAPLIRSVSEYPANVSPPAQ-SLQLPKSTS---------------- 295

  Fly  1295 GSCANDSINPGGGAGCNMDLSTSVASTTPSTSGSVAAGLSAFAEL-NALDTV--DKE-------- 1348
                    ||.       ||..|:||.  |:..::.:||..|:.: :...|.  |:|
pombe   296 --------NPA-------DLHLSIASA--SSHKNIFSGLDVFSNVFHGPSTTLRDREHDMRNRSF 343

  Fly  1349 ----------ARRERYSQHPKHKSAPVSVNRSESYKERLSNKRNRNSRRKTSDP----------- 1392
                      .:::|....|..:|..:|     |||.|.|.....|.|..|:.|
pombe   344 DHSTLAHYEAVKQQRLGVEPTARSFTLS-----SYKSRASGNSLINDRSSTTTPTFVNSEASSPV 403

  Fly  1393 -----------SLSSRPNDEQLD-LGLSNATYVGSSNSSLSSAGGSESPSTSMEHFAAPGAA--- 1442
                       :|.||...|.|| |.|.:.|..|...|:..:...:.:....:.|.:....|
pombe   404 HKNKRRRRIYAALLSRVASELLDRLQLGDITKDGLIYSNAFTGDHAVTVLMGIIHTSDRNLALLV 468

  Fly  1443 GGVQVPPMGLNQNQHPHLLIQQHAQQYCQQDSFQAGLAGAAGSSAASN----------------- 1490
            |........::...:.|.|...|.:.|..|.:.......|..:::.:|
pombe   469 GRSLDAQKFIHDVTYDHRLRDSHREIYQLQGTGYRPFLRANDNASINNKNHHKELEDNESGTRIS 533

  Fly  1491 ------SSFWNA---------------GHP-----LP---------VARWTLESEDE-----DDV 1515
                  :||.|.               .||     .|         .|:....:|..     ||.
pombe   534 PSTLGDTSFPNGIFTLLTHCYSPTCAKDHPCYSISCPRRLEQQHRLFAKMRANTEQSSSLAFDDK 598

  Fly  1516 NEADWSSMVAAEVLAALTDAEKKRQEIINEIYQTERNHVRTLKLLDRLFFLPLYESGLL----SQ 1576
            .:..|...|..|:..:::|.|:||||:|.|:..|||:.|:.|:.|...:..||:.|..:    .:
pombe   599 EQKLWIHSVPQEIAYSVSDRERKRQEVICEVIYTERDFVKDLEYLRDYWIKPLWASSCIPERKKE 663

  Fly  1577 DHLLLLFPPALLSLREIHGAFEQSLKQRRIEHNHVVNTIGDLLADMFDGQSGVVLCEFAAQFCAR 1641
            ..:..:|..| |.::.::....::|.:|: .:..:|:.|.|:..:      .|...|...::.|.
pombe   664 KFIRTVFLNA-LEVQAVNSKLAEALTKRQ-NYKPIVDNIADIFLE------HVPKFEPFIRYGAG 720

  Fly  1642 QQIALEALKEKRNKDEMLQKLLKKSESHKACRRLELKDLLPTVLQRLTKYPLLFENLYKVTVRLL 1706
            |.......:::::.:....|.:...|..|..|:|||...|.....||.:||||.|.:.|.|
pombe   721 QLYGKYEFEKEKSSNPAFAKFVSDVERLKESRKLELNGYLTKPTTRLARYPLLLEAVLKYT---- 781

  Fly  1707 PENTTEAEAIQRAVESSKRILVEVNQAVKTAEDAHKLQNIQRKL---------------DRSSYD 1756
            .|...:.:.|.:.:...:..|..:|.....||:...|.::.::|               :|....
pombe   782 DEGNPDKQDIPKVINIVRGFLSRLNVESGKAENKFNLFHLNQQLVFKPGEHYDLHLLDANRQLIF 846

  Fly  1757 KEEFKK-----------LDLTQHHLIHDGNLTIKKNPSVQLHGLL--FENMIVLLTKQ----DDK 1804
            |...||           .|:|.  .:.|..|.|.|..::....||  |:..|.||..|    ||
pombe   847 KGPLKKRSAGSTSSESASDVTL--FLFDHALLIVKPKTINKRELLKVFQRPIPLLLLQLFLVDD- 908

  Fly  1805 YYLKNLHTPLS-----------ITNKPVSPIMSIDADTLIRQEAADKNSFFLIKMKTSQMLELRA 1858
               ..|..|.|           ...||.|.........|.|:               ...:.|.|
pombe   909 ---NGLRIPYSSKQQLAAVSKAANGKPPSRFYPFSLQLLGRR---------------GYEITLYA 955

  Fly  1859 PSSSECKTWFKHF-SDVAARQSKNR---SKNASSNHDTSISDPALAAIPHSNTKESLELSTDTVQ 1919
            .:......|.:|. :.....|.:|:   |....||.  .:.|..:.||...::...|...|||
pombe   956 TTEVSRDKWLEHIDNQQTLLQHRNQWFESVTICSNF--FVGDNKVNAIGVYDSGRRLLYGTDT-- 1016

  Fly  1920 PLAATATLTTTPLAPMLPIATVTPAPATNNSNVSSLTGVQ 1959
            .:..:.....:||       ...|..|.|..|:|.|..::
pombe  1017 GVYVSLRKANSPL-------QFKPVRALNIPNISQLEVIE 1049

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF2	NP_477317.1	PDZ_ARHGEF11-12-like	258..333	CDD:467282
		RGS_GEF_like	934..1055	CDD:188710
		C1_ARHGEF-like	1150..1202	CDD:410382	15/80 (19%)
		RhoGEF	1539..1731	CDD:238091	46/195 (24%)
		PH_16	1756..1876	CDD:436083	30/148 (20%)
rgf1	NP_588116.1	ROM1	6..1320	CDD:227709	210/1080 (19%)