Protein Alignment RhoGEF2 and Plekhg6

DIOPT Version :10

• Sequence 1: NP_477317.1
• Gene: RhoGEF2 / 36915
• FlyBaseID: FBgn0023172
• Length: 2559
• Species: Drosophila melanogaster
• Sequence 2: NP_941006.2
• Gene: Plekhg6 / 213522
• MGIID: 2682298
• Length: 787
• Species: Mus musculus
• Alignment Length: 869
• Identity: 187/869 - (21%)
• Similarity: 298/869 - (34%)
• Gaps: 250/869 - (28%)

  Fly  1398 PNDEQLDLGLSNA---TYVGSSNSSLSSAGGSESPSTSMEHFAAPGAAGGVQVPPMGLNQNQHPH 1459
            ||:..|. ||..:   ||.|...:|..|..|:..|            .||..|.|.
Mouse     7 PNEGPLQ-GLVASRIETYGGRHQTSAHSTAGNLFP------------RGGPGVDPS--------- 49

  Fly  1460 LLIQQHAQQYCQQDSFQAGLAGAAGSS---------AASNSSFWNAGHP---------------- 1499
               ::..|.|.   .|..|.....|.|         ...:.|::..|.|
Mouse    50 ---RRRLQHYV---PFAKGSGQTRGMSPLVLREPDPEKRHGSYFGVGPPHSPKLKEVTRAHELEI 108

  Fly  1500 ------------LPV---ARWTL-ESEDEDDVNEADWSSMVAAEVLAALTDAEKKR-----QEII 1543
                        ||.   ..|.: |..|.....|..|..:|       |...|..|     ||.:
Mouse   109 RLHTFSMFGMPRLPPEDRRHWEIGEGGDSALTMEKSWKELV-------LEHKEMNRQLCHQQEAL 166

  Fly  1544 NEIYQTERNHVRTLKLLDRLF---FLPLYESGLLSQDHLLLLF--PPALLSLREIHGAFEQSLKQ 1603
            .|:..||..::|.||::..|.   .|.|...|||::.....||  .|.|:   ..|..|.:.:.|
Mouse   167 WELLTTELIYLRKLKIMTDLLAAGLLNLQRVGLLTEVSAETLFGNVPNLI---RAHRRFWEEVLQ 228

  Fly  1604 RRIEHNHVVNTIGDLLADMFDGQSGVVLCEFA------AQFCARQQIALEALKEKRNKDEMLQKL 1662
            ..:|.   ..|.|..| |....|:|.:  .|.      .|:|.|.:..:...:|:::.:.:....
Mouse   229 PILED---TRTSGQPL-DPVSLQNGFL--TFGQRFQPYVQYCLRVKQTMAYAREQQDTNPLFHTF 287

  Fly  1663 LKKSESHKACRRLELKDLLPTVLQRLTKYPLLFENLYKVTVRLLPENTTEAEAIQRAVESSKRIL 1727
            ::..|.||...|..|.|||....||:||||||.:.:.|.:    ||...: ||:...:|:.:..|
Mouse   288 VQWCEKHKRSGRQTLGDLLIKPHQRITKYPLLLQAVRKRS----PEPRAQ-EALNAMIEAVESFL 347

  Fly  1728 VEVNQAVKTAEDAHKLQNIQRK------LDRSSYDKEE----FKKLDLT----------QHHLIH 1772
            ..:|..|:..|:...|..:.::      |:.||.:.|:    |..|||.          ...|:.
Mouse   348 RHINGQVRQGEEQESLMAVAQRIGPYEVLEPSSEEVEKNLRPFSTLDLMTPVLGVAPEYTRQLLL 412

  Fly  1773 DGNLTIK--KNPSVQLHGLLFENMIVLLTKQDDKYYLKNLHTPLSITNKPVSPIMSIDADTLIRQ 1835
            :|.:.:|  :...:.::..||.:::::...|......|.:..||.:             :.|:.:
Mouse   413 EGPVRVKEGREGKMDVYLFLFSDVLLVTKPQRKADRAKVIRPPLML-------------EKLVCR 464

  Fly  1836 EAADKNSFFLIKMK----TSQMLELRAPSSSECKTWFKHFSDVAARQSKNRSKNASSNHDTSISD 1896
            ...|.|||.||.:.    .|..|.:..|||:|...|.:..........|.:.:...
Mouse   465 PLRDPNSFLLIHLTEFQCVSSALTVHCPSSTERARWLEKTQHAQTTLQKLKGEQYI--------- 520

  Fly  1897 PALAAIPHSNTKESLELSTDTVQPLAATATLTTTPLAPMLPIATVTPAPATNNSNVSSLTGVQLR 1961
                    ...:|.|.|..:     ..|.:.:|.|..|       :|:|..:.|:....| ::..
Mouse   521 --------QQKRELLALYRN-----QGTESPSTRPSTP-------SPSPEDSQSSAEGRT-LEFA 564

  Fly  1962 NPQRDATASESDADYVNTP--------------KPRSSQNEVNRTMSIRSTGEPIQKYSANGTEA 2012
            ...|.....::|.|..:.|              .|:.|.:.:||..|.....:|...:|.  .|.
Mouse   565 IIPRLVVTEDTDEDTPSMPDDASDSGYGTLIPSSPKDSHSPLNRLRSKALRRDPRLTFST--LEL 627

  Fly  2013 NDVTLRHSQSTRESVRPGSTGEERNST----YGMVGGNSKRDSASIVCSNNSNNT--------RT 2065
            .||.||...       |.....:|.|.    .|::.|.|....|..:.|...:.|        .|
Mouse   628 RDVPLRPQP-------PDPQAPQRRSAPELPEGILRGGSLPRRAPPIWSEEEDETLASGNVVVET 685

  Fly  2066 L---LMQSPLVDPTAIQVSISPAHT-------------AEPVLTPGEKLRRLDASIRNDLLEKQK 2114
            |   ..:|||..        ||.||             .|.:|:|..:.|    |:|.|:|.:
Mouse   686 LHRAQRRSPLPH--------SPTHTDSAGESPWESSDEDEGLLSPELRPR----SLREDMLRE-- 736

  Fly  2115 IICDIFRLPVEHYDQIVDIAMMPE 2138
                   :..|..:|.:|.|..||
Mouse   737 -------IREELANQRIDGASEPE 753

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF2	NP_477317.1	PDZ_ARHGEF11-12-like	258..333	CDD:467282
		RGS_GEF_like	934..1055	CDD:188710
		C1_ARHGEF-like	1150..1202	CDD:410382
		RhoGEF	1539..1731	CDD:238091	57/207 (28%)
		PH_16	1756..1876	CDD:436083	28/139 (20%)
Plekhg6	NP_941006.2	RhoGEF	165..351	CDD:459876	54/199 (27%)
		PH_PLEKHG5_G6	408..505	CDD:270064	23/109 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	533..762		56/259 (22%)