DRSC/TRiP Functional Genomics Resources

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Protein Alignment RhoGEF2 and RhoGEF2

DIOPT Version :10

Sequence 1:NP_477317.1 Gene:RhoGEF2 / 36915 FlyBaseID:FBgn0023172 Length:2559 Species:Drosophila melanogaster
Sequence 2:XP_061516046.1 Gene:RhoGEF2 / 1278895 VectorBaseID:AGAMI1_006778 Length:2405 Species:Anopheles gambiae


Alignment Length:2687 Identity:1033/2687 - (38%)
Similarity:1332/2687 - (49%) Gaps:648/2687 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   203 NQSDNSNPVLQAPGERSSLNLTPLSRDLSGG------HTQESTTPATTPSTPSLALPKN----FQ 257
            |.|.|:.|..::|....:..: |.:::.|.|      ..|::..|.....||:...|.|    .|
Mosquito     4 NLSSNAGPPERSPIHNQTSRI-PTNQNGSAGSPRQQQQQQQTQQPRPQTLTPTRESPANGSMAMQ 67

  Fly   258 YLTLTVRKDSNGYGMKVSGDNPVFVESVKPGGAAEIAGLVAGDMILRVNGHEVRLEKHPTVVGLI 322
            .|.:||.||:.|||||||||.|||||||||||||..|||:..||||:|||..||...|..||.||
Mosquito    68 TLVVTVNKDATGYGMKVSGDKPVFVESVKPGGAARRAGLMPDDMILKVNGTSVRALTHTHVVELI 132

  Fly   323 K-ASTTVELAVKR-SQKLTRPS-SVSVVTPSTPILSGRDRTASITGPQPVDSIKRREMETYKIQT 384
            | ||..|||.|:| |.::.||| |.:.:.|.||:.    :..|||.|||||..|:||||.:|:.|
Mosquito   133 KAASDVVELTVQRGSNRMQRPSPSTNSIAPMTPVA----QRNSITAPQPVDCAKQREMEVHKMNT 193

  Fly   385 LQKMLEQEKLNLERLKSDQNNPSYKLS--EANIRKLREQLHQVGAEDAPTVKLQAAAGNKNTALL 447
            ||.||:|.|.:.:.|.: .|.|..:::  :|.|:||.::|.|:..|                   
Mosquito   194 LQLMLDQVKKSRDTLIA-TNKPPVEVARVDATIQKLEKELQQMLGE------------------- 238

  Fly   448 TPNQIQHLSASATHSNQQFHHLHHHHNLHNNNYPPQQQPASTSPAFLSLLPRSLSSLSLGTRKNK 512
             |......|.||..|...|         .....|...|..||:|||||..|||||||||||:|..
Mosquito   239 -PGTYPAFSPSALSSPPLF---------PQPQLPNSAQTTSTTPAFLSRFPRSLSSLSLGTKKKS 293

  Fly   513 TE-KDLTTSS------------------PFGLTTDFLQQQRMSHQAESMSQSMHQHTSTPTSQQF 558
            .: |::::.|                  |||..|......:...:..:.|.:.|.|         
Mosquito   294 IDSKEISSPSAATLFGSPECLSPTDGGGPFGGLTSSGTPTKSGKKYSASSAADHHH--------- 349

  Fly   559 FHPH------------QQQHRFKETGPTSKGKNKFLISRSLIEEDVPPPLPQRN--PPR---QLN 606
             |.|            ...|....:| ...||.:...|     .|:||||||||  |.|   .::
Mosquito   350 -HHHLHGSGGGGGGGNHHGHHLNRSG-NFGGKQQQQQS-----ADIPPPLPQRNNIPKRADDTVD 407

  Fly   607 LDLKNGNASPGGSHLVAPVSDLDR--ATSPQLNRSQQQQLPSSTDNSPSNA------KSKRSKIK 663
            :.|.       ||.....|||||.  ..||....:.......||.::.|.|      ||.|.|.|
Mosquito   408 MMLV-------GSRRNILVSDLDHQLVLSPAAQETASLHSAGSTGSASSKASGGGSGKSSRGKKK 465

  Fly   664 --------TKALSDPKMSTQMFLQMESASAAGAAGGSIE----VDGG--------------PPPL 702
                    :.::|....:..   ...|:|..|.|..|::    :||.              ||||
Mosquito   466 NGSSAAAHSNSVSSSNNNNN---NNHSSSKGGNANSSVDTTTLLDGNVLATATATTELQAEPPPL 527

  Fly   703 PPRLPGMM------------------------------------TEDMSRGSCQNLAQPNSVGTA 731
            |||.|||:                                    .....|||.:....|||:.|.
Mosquito   528 PPRQPGMLEVVNQNLILNSDNNAGSSSSNGANSTTAASTPNGNNNHSSGRGSLEMRPPPNSINTL 592

  Fly   732 FNYPLVSTTTAVQNDNLNIAFPLSQRPNIVQQLQQYQQQQQHQMSGGQATGALGQTPNLGKNKHR 796
            .||||::|.|:|: ||:..|||||.|||||.|:||:||..  .|:...|.|| |...::.| |||
Mosquito   593 MNYPLITTCTSVR-DNMAAAFPLSYRPNIVHQMQQHQQST--AMNQSAAAGA-GVNQSISK-KHR 652

  Fly   797 RVGSSPDNM-------------HPRHPD--RITKTTSGSWEIVEKDGESSPPGTPPPPYLSSS-- 844
            |:.|||:|:             |..|..  |..||:|.||   :|..|.:|||||||||||:|  
Mosquito   653 RIVSSPENIGAKDFGMVAGADHHHHHSGGYRHHKTSSDSW---DKRSEITPPGTPPPPYLSTSMT 714

  Fly   845 --------------------------------HMTV--------LEDPNEN-----------NRG 858
                                            |.|.        |...|.|           |.|
Mosquito   715 TGSPAGGGGHPQQQHHPHHHHHHGGHHPHHHEHTTAGDLAIANPLSSINNNHHHHHQQQHHGNNG 779

  Fly   859 AA---AAGP---------------GVFIESHQFTPMAGASSPIPI-------------SLHSSHM 892
            .|   |.||               .....:|...|..|..||:..             :...|.:
Mosquito   780 TATHPATGPNNINSINNNNGASHMSASYHAHHHHPSHGQQSPVGATNAGGPAGGVGGGTAPGSSI 844

  Fly   893 HAAQSNDTQKEIISMEDENSDLDEPFIDENGPFNNLTRLLEAENVTFLAIFLNYVISNSDPAPLL 957
            .|||:|..||.||||||::....|.||:||.||.:||:||||:...:||:|||:|::||||:.||
Mosquito   845 VAAQANVAQKPIISMEDDDISDQESFIEENSPFRSLTQLLEADKSVYLAVFLNFVLTNSDPSALL 909

  Fly   958 FYLITELYKEGTSKDMRKWAYEIHSTFLVPRAPLSWYRQDESLAREVDNVLQLEYDKVEILRTVF 1022
            ||:||.||||||.|||||||||||||||||.|||.....||:|||::|:|||.|.||.||||.||
Mosquito   910 FYMITMLYKEGTVKDMRKWAYEIHSTFLVPGAPLLCANVDEALARDIDDVLQKENDKAEILRMVF 974

  Fly  1023 LRSRKRAKDLISEQLREFQQKRTAGLGTIYGPTDDKLAEAKTDKLREQ-IIDKYLMPNLHALIED 1086
            .|||.:||::|::||::||.||||||||:|||.|.:|..||.||::|| |||:.|:|.|...:::
Mosquito   975 WRSRLKAKEMINQQLQQFQTKRTAGLGTMYGPNDQQLQMAKGDKVKEQRIIDETLLPKLQQYLDE 1039

  Fly  1087 -ENGSPPEDVRKVALCSALSTVIYRIFNTRPPPSSIVERVHHFVSRDKSFKSRIMGKNRKMNVRG 1150
             |..||.||.:|.|||||||||:.|||.||..|...:::|||||||:||||||:|.||||..:.|
Mosquito  1040 LERESPKEDPKKSALCSALSTVLMRIFVTRCNPGGPIDKVHHFVSREKSFKSRLMAKNRKQTILG 1104

  Fly  1151 HPLVLRQYYEVTHCNHCQTIIWGVSPQGYHCTDCKLNIHRQCSKVVDESCPGPLPQAKRLAHNDK 1215
            |.|.|:.|||||.|||||.|:|||||||||||:|:|||||.|:|.:.|.||||..|    .::.|
Mosquito  1105 HNLHLQPYYEVTRCNHCQNILWGVSPQGYHCTNCELNIHRACAKDLVECCPGPAIQ----KNDSK 1165

  Fly  1216 ISKFMGKIRPRTSDVIGNEKRSRQDEELDVELT--PDRG-QASIVRQPSDRRPDANISIRSNGNT 1277
            |:|.|.||..|...   .:|..|.|::...:.|  .:|| ..|:.|||||||.|.:..:      
Mosquito  1166 ITKLMEKISSRNHH---QDKSRRHDDDATADDTTISERGANTSLARQPSDRRQDLSGQL------ 1221

  Fly  1278 SCNTSGLNTTDLQSSFHGSCANDSINPGGGAGCNMDLSTSVASTTPSTSGSVAAGLSAFAELNAL 1342
             .||||              |:|.:|                     .|.|.|.|..        
Mosquito  1222 -ANTSG--------------ASDHLN---------------------NSSSDAYGYK-------- 1242

  Fly  1343 DTVDKEARRERYSQHPKHKSAPVSVNRSESYKERLSNKRNRNSRRKTSDPSLSSRPNDEQLDLGL 1407
                :.|..:::.::.|.|||||||||||||||| |.|:.|.:|||||||||:...:::.....|
Mosquito  1243 ----QSADDDQFRENVKSKSAPVSVNRSESYKER-SQKKTRTTRRKTSDPSLTKTADEQNEASSL 1302

  Fly  1408 SNATYVGSSNSSLSSAGGSESPSTSME--------HFAAPGAAGGVQVPPMGLNQNQHPHLLIQQ 1464
            :|..|..||.|||..|  .:|.|.|||        ..::.|.||.|.    |:|...        
Mosquito  1303 ANNNYSSSSTSSLPLA--LDSRSASMEAVGGGATTAVSSAGPAGTVS----GINPTH-------- 1353

  Fly  1465 HAQQYCQQDSFQAGL--------------AGAAGSSAASNSSFWNAGHPLPVARWTLESEDEDDV 1515
                     |...|:              .|..|....|..|....|..:|.||..::|:||..|
Mosquito  1354 ---------SSPGGVGLPSSASTTSGGTGGGLHGGPVGSGGSGGPGGLNVPTAREWIDSDDEGTV 1409

  Fly  1516 N-EADWSSMVAAEVLAALTDAEKKRQEIINEIYQTERNHVRTLKLLDRLFFLPLYESGLLSQDHL 1579
            . ||||||.:|.|:|:::.|.||||||:|||||||||||||||:||:.:|..||.|||.|..|.|
Mosquito  1410 EPEADWSSNIAPEILSSIGDLEKKRQEVINEIYQTERNHVRTLRLLEGIFMRPLQESGALPHDLL 1474

  Fly  1580 LLLFPPALLSLREIHGAFEQSLKQRRIEHNHVVNTIGDLLADMFDGQSGVVLCEFAAQFCARQQI 1644
            .||||.:|:.|:::|.|||..|||||.||.::|..|||||..|||||:|..|.|.||.|||||||
Mosquito  1475 NLLFPHSLIHLKDLHTAFELKLKQRRSEHGNIVREIGDLLLTMFDGQTGEELKEHAAHFCARQQI 1539

  Fly  1645 ALEALKEKRNKDEMLQKLLKKSESHKACRRLELKDLLPTVLQRLTKYPLLFENLYKVTVRLLPEN 1709
            |||||||:|.|||.||::|.|:|||||||||:|||||||.|||||||||||:|||..|||..|:|
Mosquito  1540 ALEALKERRKKDEQLQRILTKAESHKACRRLQLKDLLPTALQRLTKYPLLFDNLYNFTVRSTPKN 1604

  Fly  1710 TTEAEAIQRAVESSKRILVEVNQAVKTAEDAHKLQNIQRKLDRSSYDKE---EFKKLDLTQHHLI 1771
            ..||.||:::.||:||||..|||||:|.||.|||..||||||:|..|||   |||.:|||...||
Mosquito  1605 EGEALAIRKSHESAKRILDHVNQAVRTEEDMHKLATIQRKLDKSGLDKEAAVEFKNIDLTVRKLI 1669

  Fly  1772 HDGNLTIKKNPSVQLHGLLFENMIVLLTKQDDKYYLKNLHTP------LSITNKPVSPIMSIDAD 1830
            |||.||:||||.|||||||||:::|||.||||||.:|...:|      ........:||..|.. 
Mosquito  1670 HDGPLTMKKNPGVQLHGLLFEDIMVLLQKQDDKYLVKYHSSPGLGGSESKYAEGRFNPITKIHL- 1733

  Fly  1831 TLIRQEAADKNSFFLIKMKTSQMLELRAPSSSECKTWFKHFSDVAARQSKNRSKNASSNHDTSIS 1895
            .|:||.|.|||:||||....||||||.||||:||||||||.|| ||...|:|:|......:.|..
Mosquito  1734 ILVRQSAVDKNTFFLINTNVSQMLELTAPSSTECKTWFKHISD-AAEAYKSRTKGTHEYGEDSAG 1797

  Fly  1896 DPALAAIPHSNTKESLELSTDTVQPLAATATLTTTPLAPMLPIATVTPAPATNNSNVSSLTG--- 1957
            ..|     ....|:|.|..|:| |.:..|:|          ||..: ....|....|||..|   
Mosquito  1798 GGA-----GQPPKDSFETVTET-QKIEQTST----------PIERL-ERKDTQCRAVSSSAGHHH 1845

  Fly  1958 -----VQLRNP---QRDATASESDA----DYVNTPKPRSSQNEVNRTMSIRSTGEPIQKYSANGT 2010
                 .|..:|   |:.:.||:..|    .:.:.|:....:::.:|..|:  .|.| ....||.|
Mosquito  1846 HHHHPAQPHHPHQQQQQSPASQQAAGQPHHHHHHPQSGGGRSDDSRLPSV--PGAP-DSSGANET 1907

  Fly  2011 EANDVTLRHSQSTRESVRPGS---------TGEERNSTYGM---------VGGNSKRDSASIVCS 2057
            |.|.......:..|.|.|.||         :.:|.....|.         ..|.|.|       .
Mosquito  1908 EDNLENEEKEKFKRSSRRHGSREECNGGGRSSDEEEEENGQQDDEDDERYTRGQSGR-------Q 1965

  Fly  2058 NNSNNTRTLLMQSPLVDPTAIQVSISPAHTAEPVLTPGEKLRRLDASIRNDLLEKQKIICDIFRL 2122
            .:||||||:..|..||.|:.|.||:|...||||:|||.|:|||.|..|:..|..||:::||:|::
Mosquito  1966 GSSNNTRTITQQCSLVAPSEIHVSVSATLTAEPILTPAEQLRRYDQLIQKTLASKQRVVCDMFKV 2030

  Fly  2123 PVEHYDQIVDIAMMPEAPKDSADIALAAYDQIQTLTKMLNEYMHVTPEQEVSAVSTAVCGHC--- 2184
            |.||:..|.|||..|||||:..|:.|||:...|||.::::|.|.|:..|:|||||||||..|   
Mosquito  2031 PDEHFQAIADIAAQPEAPKEPTDLVLAAFAYGQTLMEIVSECMRVSESQQVSAVSTAVCDDCSVL 2095

  Fly  2185 -------------HE----------KEKLRKKVAP----------------------SSSFSSSP 2204
                         |.          ||.|.:...|                      ::.::|:|
Mosquito  2096 AAAADRTKQSNHHHHIPSPTTTTTTKEPLSEPTVPTIGGGPVPSATAASATISTATTATFYNSAP 2160

  Fly  2205 PPLPPPNRQHAQAQAQIPPSRLMPKLQTLDLDEVAIHEDDDGYCEIDELRLPAIPSKPHERPTTP 2269
            .|:..     ..||.|                .|:|.||:||||||||:|..|:....:|:    
Mosquito  2161 APIGV-----VAAQDQ----------------NVSITEDEDGYCEIDEVRAAAVLLAENEK---- 2200

  Fly  2270 LAPFNTEPKTSQSVIDASKRQSTDAVPEGLLEQEPLEGDKTETKGEDNEVKTVPSDKLSESCNEE 2334
                                                                  :.||:|:.   
Mosquito  2201 ------------------------------------------------------ARKLTEAA--- 2208

  Fly  2335 RQCVEADITKEVADPTTSKNEAAASVDELPSQSREIKTAENASKSVADKKEDNEETIEEGVASTV 2399
                           ..:....|:.||.|....    ....||:|.....|.||         ..
Mosquito  2209 ---------------AAAGGGVASGVDTLDDGG----DVGRASQSPESHIEINE---------NY 2245

  Fly  2400 DSSTQTSPTESPKETDKLTGGS--SSTCGPNRIQHASVLEPSVPCHALSSIVTILNEQISMLLPK 2462
            ||      |:||..|.|.:|.:  ...||.||:.|||.|.|:||||.::|.||.||.|||.||.|
Mosquito  2246 DS------TQSPSMTQKYSGTALGPEQCGKNRLLHASNLAPTVPCHLIASYVTGLNSQISQLLHK 2304

  Fly  2463 INERDMERERLRKENQHLRELLSALHDRQRVDEVKETPFDLKKLMHAEDVEFDDDIDAISNSSLT 2527
            |:|:|||||.||:|||||||||:|:| ::||.|.:||..|.::....::......:.||......
Mosquito  2305 ISEKDMEREHLRRENQHLRELLNAMH-QERVLESQETNQDQQQNAPGDEQTTSSSLSAIGPEVAA 2368

  Fly  2528 PTPTPI------PTASPSASGQ 2543
            ..|.|.      || ||| ||:
Mosquito  2369 TQPPPSQQQQQQPT-SPS-SGE 2388

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGEF2NP_477317.1 PDZ_ARHGEF11-12-like 258..333 CDD:467282 50/75 (67%)
RGS_GEF_like 934..1055 CDD:188710 81/120 (68%)
C1_ARHGEF-like 1150..1202 CDD:410382 36/51 (71%)
RhoGEF 1539..1731 CDD:238091 129/191 (68%)
PH_16 1756..1876 CDD:436083 74/128 (58%)
RhoGEF2XP_061516046.1 None

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