DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15617 and Grip2

DIOPT Version :9

Sequence 1:	NP_611151.1	Gene:	CG15617 / 36871	FlyBaseID:	FBgn0034151	Length:	222	Species:	Drosophila melanogaster
Sequence 2:	XP_006506166.1	Gene:	Grip2 / 243547	MGIID:	2681173	Length:	1049	Species:	Mus musculus

Alignment Length:	259	Identity:	52/259 - (20%)
Similarity:	86/259 - (33%)	Gaps:	84/259 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KIRVPKYDSDAFDNVAYELQMTYTLETDCRIMSFYDAMWGMEVTGGIDQFEPLTIVNVSPTGLAK 69
            |:::.| |.|..|.......::||:|     :..|....|:.::|..:.|:|:.|..::..|||:
Mouse   643 KLKIRK-DEDNSDEQESSGAVSYTVE-----LKRYGGPLGITISGTEEPFDPIIISGLTKRGLAE 701

  Fly    70 R-GGMRVGDEITQINDVPALEMTFNEALQMFRKNSRYVRVYVRGDDDAP------GEEDWTCD-- 125
            | |.:.|||.|..||.|.......:||:.:.:.....|.:.::...|.|      |......|
Mouse   702 RTGAIHVGDRILAINSVSLKGRPLSEAIHLLQVAGETVTLKIKKQLDRPLLPRQSGSLSEASDVD 766

  Fly   126 -------------CWFKPRKP--------WR--------------------RDFTPIQWTFPWND 149
                         ..|.|..|        |.                    |..||.:|.
Mouse   767 EDPPEALKGGLLATRFSPAVPSVDSAVESWGSSATDGGFGGTGSYTPQVAVRSVTPQEWR----- 826

  Fly   150 RRKPVYKESNCFMVPSKMEEK---IRARRAATSAVHKKDELAPHTRS-----LTPTPRPKNQPG 205
                          ||:::..   :..||.:.:. ...||..|....     ::|.|.|..:.|
Mouse   827 --------------PSRLKSSPPPLEPRRTSYTP-GPSDESFPEEEGDWEPPMSPAPGPAREEG 875

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15617	NP_611151.1	PDZ_signaling	30..111	CDD:238492	22/81 (27%)
Grip2	XP_006506166.1	PDZ_signaling	58..140	CDD:238492
		PDZ_signaling	160..243	CDD:238492
		PDZ_signaling	258..341	CDD:238492
		PDZ_signaling	463..551	CDD:238492
		PDZ_signaling	564..647	CDD:238492	1/3 (33%)
		PDZ_signaling	664..744	CDD:238492	24/84 (29%)
		PDZ_signaling	947..1026	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810