DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4945 and unm_sa1261

DIOPT Version :9

Sequence 1:	NP_788382.1	Gene:	CG4945 / 36850	FlyBaseID:	FBgn0034137	Length:	577	Species:	Drosophila melanogaster
Sequence 2:	XP_684216.2	Gene:	unm_sa1261 / 557524	ZFINID:	ZDB-GENE-120411-10	Length:	409	Species:	Danio rerio

Alignment Length:	417	Identity:	132/417 - (31%)
Similarity:	200/417 - (47%)	Gaps:	54/417 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSKKP---RGNIHKIREFE------LEKIQLVDEFDIIQIVGEGWFGKILLVEHRGSQTEMVLKA 56
            ||..|   |.:...:.|.:      |||:.....:::|:.:|:|.:||:.||.|:...|:|.||.
Zfish     1 MSSSPLVSRSSNDILEELQLITAKNLEKLDFNKYYEVIRELGKGTYGKVDLVVHKIRGTKMALKF 65

  Fly    57 VPKPYVTLRDFYREFHYGLHLGVHRHIVTTYDVAFETAGFYVFTQEYAPLGDLTSNVTDS-GVGE 120
            :.|....|:.|.||:...|:|.....|:..|.:||||..:|:|.|||||.|||...:... |:.|
Zfish    66 LRKKTTKLKSFLREYSISLYLSPCHFIINMYGIAFETDEYYIFAQEYAPAGDLFDIIPPQVGLPE 130

  Fly   121 VYSKRVAKQLASAIDYMHSKDIVHRDIKLDNVLIYRSDFQRIKLCDFGESFPTGSTVERRNEWLP 185
            ..:||...|:|.|:||:|.|.:||||||.:||||:..:.:::||.|||.:...||.|:|.:..:|
Zfish   131 NVAKRCVHQVAIALDYLHCKKLVHRDIKPENVLIFDKECRKVKLSDFGMTRRAGSPVKRVSGTIP 195

  Fly   186 YSPPEVLEIKPEGSYKADPSHDVWQFGIVIFVCLTGCLPWQKAASDDPRYVRYLAWQGGLMMMPL 250
            |:.||:.:...:.....|.|.|||.||:::|..|||..||:||...|..|..::.||     ...
Zfish   196 YTAPELCDPGRQEGLCVDYSTDVWAFGVLLFCMLTGNFPWEKALPSDAFYEEFVRWQ-----QRR 255

  Fly   251 RRT---PRLFKLLTSNAQRMFKRFFARISNRPKSLADVTKFLDDRWLAKTAQKEMAEYETDELCP 312
            ||:   |..::..|..|..||:...:...:|..|:.:|..:.:..|:..|....
Zfish   256 RRSSSVPSQWRRFTEEALCMFRCLLSIEQDRRCSVKEVFSYFNHCWMLDTENGN----------- 309

  Fly   313 SMYSFHSSPDEKNKLLYTLADCGIETNVDRQQKKNRIKDWIESSIITEEDEEENEETNSASPSSS 377
               :.|.|....|.        |...| .||.:       :.||...|:|..:.....|.||...
Zfish   310 ---TTHISSSNGNS--------GTVMN-GRQAE-------LSSSSSEEDDLVDRLNKQSLSPVCG 355

  Fly   378 VSR-----EPLPGHISSLRKPTSPAES 399
            |::     ||:..|.|| ....|||.|
Zfish   356 VTKGGIIMEPVTTHYSS-TSTNSPASS 381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4945	NP_788382.1	SPS1	25..358	CDD:223589	109/336 (32%)
CG4945	NP_788382.1	STKc_SBK1	32..293	CDD:270889	97/264 (37%)
unm_sa1261	XP_684216.2	S_TKc	35..302	CDD:214567	98/271 (36%)
unm_sa1261	XP_684216.2	STKc_SBK1	41..301	CDD:270889	97/264 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590137
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1345
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	186	1.000	Inparanoid score	I3917
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1221624at2759
OrthoFinder	1	1.000	-	-		FOG0002130
OrthoInspector	1	1.000	-	-		mtm6333
orthoMCL	1	0.900	-	-		OOG6_106722
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4887
SonicParanoid	1	1.000	-	-		X768
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.690