Protein Alignment CG4945 and ikke-1

DIOPT Version :10

• Sequence 1: NP_788382.1
• Gene: CG4945 / 36850
• FlyBaseID: FBgn0034137
• Length: 577
• Species: Drosophila melanogaster
• Sequence 2: NP_871627.1
• Gene: ikke-1 / 176278
• WormBaseID: WBGene00011299
• Length: 820
• Species: Caenorhabditis elegans
• Alignment Length: 595
• Identity: 115/595 - (19%)
• Similarity: 177/595 - (29%)
• Gaps: 234/595 - (39%)

  Fly   133 AIDYMHSKDIVHRDIKLDNVLIY-------RSDFQRIKLCDFG--ESFPTGSTVERR------NE 182
            |:..:...:|.|||||..|:|::       |......||||.|  :|....|:.|.|      |.
 Worm   136 ALSALREHNIAHRDIKHMNILLFPGTPTRGRRSTHLFKLCDMGCSKSLSENSSHEMRTLVGTPNL 200

  Fly   183 WLPYSPPEVLE---------IKPEGSYKADPSHDVWQFGIVIFVCLTGCLPWQK----------- 227
            ..|:...|:::         .|.:.:|.::.. |:|..|..::.|.||..|::.
 Worm   201 LHPFLAHEMVDPLMAQNRHNWKTKSAYTSEQC-DLWALGCTLYFCATGKFPFEHERNNKSLYHKA 264

  Fly   228 --AASDDPRYVRYLAWQGG---------LMMMPLRRTPRLF----KLLTSNAQRMFKRFFARISN 277
              |.:.:|..:..:..|.|         ....|:...|..|    |.|.|....:.:.||    :
 Worm   265 VVALTQNPDAIAMVLVQKGRDPGRRTDIFEFQPVTELPAKFTRYPKWLVSTMTCLLRSFF----H 325

  Fly   278 RPK-----SLADVTKFLDDRWLAKTAQKEMAEYE------------------------TDELCPS 313
            .|.     .:||..:....|..:...|..:.|:.                        ||.|..|
 Worm   326 EPSIEYYAKVADAMRNSKRRTFSSVDQMSIVEHTDMSNVPHLGFSIPSISKCLGYPEGTDILLLS 390

  Fly   314 MYSFHSSPDEKNKLLYTLAD-------------------CGIETN-----VDRQQKKNRIKDWIE 354
            ..|.|.. |.|.|.:..|.|                   ..||.:     .||:..:.|||...|
 Worm   391 NTSTHYL-DSKQKSVDGLPDDLYLVVPQTSHVDMRKILARNIEFHEFDDMTDRKLSEIRIKKCYE 454

  Fly   355 S-SIITEEDE--------------------------------------------------EENEE 368
            . |::||.||                                                  |.|.|
 Worm   455 GLSMLTEIDEYLALFDRVSTILSTQFSLLVQELSQFERVQTASRFAVYVDMASVPLMLFDEANPE 519

  Fly   369 TNSAS----PSSSVSREPLPGHISSLRKPTSPAES-AKEINSTLKDATQKHFDPRTGALQQGPSE 428
            |...|    ..:..:||.|..|    .|.:...|: ||:::...:|...:..|      ..|..|
 Worm   520 TKMISDQCIQQAKRAREELERH----AKVSMDIEACAKQLSKDAEDLRLEDMD------LPGICE 574

  Fly   429 MGQVAMAYSKSA----------------------------SP-ASNYSTTASTLNNADSLMTLGS 464
            ..:..:.|.|.|                            || ..|.|.....:|.|.||..|.|
 Worm   575 EIESYVFYDKQAILSTQKYSQELVELCLKRRNNIMEQIFNSPDRINKSKLNKAMNLAASLSQLRS 639

  Fly   465 R----QDLLA--------------------------SNLTMYTSMETELNRLGEADPRLNQRTQS 499
            .    ||:::                          |..||..||........|:..|:.:.|:|
 Worm   640 NYRKLQDMISECVDLLEKPFQEMKDTVNRYLQAQGCSRNTMQKSMHLLRPEFHESQIRIKKTTKS 704

  Fly   500 NNPLLTTFDV 509
            ...|:...::
 Worm   705 CRKLIDQLNI 714

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4945	NP_788382.1	STKc_SBK1	32..293	CDD:270889	46/214 (21%)
ikke-1	NP_871627.1	Protein Kinases, catalytic domain	25..263	CDD:473864	31/127 (24%)