Protein Alignment Syn2 and SNTG1

DIOPT Version :10

• Sequence 1: NP_788381.1
• Gene: Syn2 / 36848
• FlyBaseID: FBgn0034135
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: NP_061840.1
• Gene: SNTG1 / 54212
• HGNCID: 13740
• Length: 517
• Species: Homo sapiens
• Alignment Length: 496
• Identity: 197/496 - (39%)
• Similarity: 294/496 - (59%)
• Gaps: 12/496 - (2%)

  Fly    25 KVRTGMVHVSDGKSRPEPLRLNLTMELLSLQKLEVVTPSSCHPNGPPMESKERMVQITRQKQGGL 89
            :.:||:..:.||...|..:||:|..::|.:|:.:|:..|     |.|..|.||.|.|.||..||.
Human     9 ETKTGICLLQDGNQEPFKVRLHLAKDILMIQEQDVICVS-----GEPFYSGERTVTIRRQTVGGF 68

  Fly    90 GLSIKGGAEHKLPILISRIYKDQAADITGQLFVGDAIIKVNGEYITACPHDDAVNILRNAGDIVV 154
            ||||||||||.:|:::|:|.|:|.|:::|.||:||||:::||..:..|.|::.|.:|||||:.|.
Human    69 GLSIKGGAEHNIPVVVSKISKEQRAELSGLLFIGDAILQINGINVRKCRHEEVVQVLRNAGEEVT 133

  Fly   155 LTVKHYRAATPFLQKQLTKD---TPDSDNDVTCAELKADEGYKSSVN-SGTISRSCSR-PMSICS 214
            |||...:.|..||:..|.:|   .|...:..|.:.| .|.|...:.: :.|.:.|||. |.|...
Human   134 LTVSFLKRAPAFLKLPLNEDCACAPSDQSSGTSSPL-CDSGLHLNYHPNNTDTLSCSSWPTSPGL 197

  Fly   215 EPEKRWTDVVAVPLMMAYVTRYIYGTDKLRQNAFEVRGLNGISTGVIHCDELAILSQWLKLITDN 279
            ..||||.|:..:||:.:..::|:.|||..|||||:|..::|:.||:|.|........||:.|..|
Human   198 RWEKRWCDLRLIPLLHSRFSQYVPGTDLSRQNAFQVIAVDGVCTGIIQCLSAEDCVDWLQAIATN 262

  Fly   280 VVGLTHLQMKLYNRNFAVGERIEYMGWVNEGVINNNISWQSYKPRFLLLKGTEVMLFETPPLNVA 344
            :..||...:|..||||.|.::|.||||. |....:.:..:.|.|.||.|:|:.:..|..||:...
Human   263 ISNLTKHNIKKINRNFPVNQQIVYMGWC-EAREQDPLQDRVYSPTFLALRGSCLYKFLAPPVTTW 326

  Fly   345 GISKALVVYKVYQTMFRIVKESETVDSRQHCFLLQSSGHEPRYLSVETRQELLRIENSWNAAIVT 409
            ..::|...:.||:.|.:|:|:|:.:|.|:.||.:||...|..|.|||...:|.:.|.::..|...
Human   327 DWTRAEKTFSVYEIMCKILKDSDLLDRRKQCFTVQSESGEDLYFSVELESDLAQWERAFQTATFL 391

  Fly   410 SVIKLGRKTFAVSHHGKSGGLTLDWQAGFSLTEGAESATVWQYKFSQLRGSSDDGKSKLKLHFQD 474
            .|.::..||:|........|||:|:..||...:.|..|.:|:||||||:|||||||||:|..||:
Human   392 EVERIQCKTYACVLESHLMGLTIDFSTGFICFDAATKAVLWRYKFSQLKGSSDDGKSKIKFLFQN 456

  Fly   475 HDSRAIETKELECQVLQSLLFCMHAFLTAKVASVDPAFLSS 515
            .|::.||.||||...|.::|.|:|:|..||||.:||.||.:
Human   457 PDTKQIEAKELEFSNLFAVLHCIHSFFAAKVACLDPLFLGN 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syn2	NP_788381.1	PDZ_syntrophin-like	77..159	CDD:467262	44/81 (54%)
		PH	301..407	CDD:214574	35/105 (33%)
SNTG1	NP_061840.1	PDZ_syntrophin-like	56..138	CDD:467262	44/81 (54%)
		PH	191..259	CDD:275388	26/67 (39%)
		PH	284..389	CDD:214574	35/105 (33%)