Protein Alignment Syn2 and Sntg2

DIOPT Version :10

• Sequence 1: NP_788381.1
• Gene: Syn2 / 36848
• FlyBaseID: FBgn0034135
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: NP_001401843.1
• Gene: Sntg2 / 298936
• RGDID: 1311276
• Length: 540
• Species: Rattus norvegicus
• Alignment Length: 516
• Identity: 198/516 - (38%)
• Similarity: 301/516 - (58%)
• Gaps: 35/516 - (6%)

  Fly    25 KVRTGMVHVSD-GKSRPEPLRLNLTMELLSLQKLEVVTPSSCHPNGPPMESKERMVQITRQKQGG 88
            :.:|.:..:.| |......:||.||.|:|::||.:||    |....|| .:..|.|.:.||..||
  Rat    24 RTKTALALLYDEGLENAYDVRLKLTKEVLTIQKQDVV----CIGGAPP-GANHRTVTLRRQPVGG 83

  Fly    89 LGLSIKGGAEHKLPILISRIYKDQAADITGQLFVGDAIIKVNGEYITACPHDDAVNILRNAGDIV 153
            |||||||||||.:|::||:|:||||||.|..||:|||:::|||..:....|::.|::||||||:|
  Rat    84 LGLSIKGGAEHGVPVVISKIFKDQAADQTEMLFIGDAVLQVNGINVENATHEEVVHLLRNAGDVV 148

  Fly   154 VLTVKHYRAATPFLQKQLTKDTPDSDNDVTCAELKADEG-YKSSVNSGTISRSCSRPMSICSEP- 216
            .:||::.|.|..||:..|....|.||:....:....|.| :.:...|.|...|.|.|  |.:||
  Rat   149 TITVEYLREAPSFLKLPLGSPGPSSDHSSRASSPLFDSGLHLNGHCSHTAPSSPSSP--IANEPK 211

  Fly   217 -EKRWTDVVAVPLMMAYVTRYIYGTDKLRQNAFEVRGLNGISTGVIHCDELAILSQWLKLITDNV 280
             ||||.|.::|||.||.::||..||:|||.:|.||..|:|.|||.:........:.||:.|:.|:
  Rat   212 YEKRWLDTLSVPLSMARISRYKAGTEKLRSSALEVLALDGASTGALQFSTAQDCADWLRAISTNI 276

  Fly   281 VGLTHLQMKLYNRNFAVGERIEYMGWVNE---GVINNNISWQSYKPRFLLLKGTEVMLFETPPLN 342
            ..||...||:.|:..:..:::.:||||||   |..||.   |:::.:||.|:|:...:|..||::
  Rat   277 NELTLQHMKMANKCCSPCDQVVHMGWVNERLQGADNNP---QNFRSKFLALRGSSFYIFSAPPVS 338

  Fly   343 VAGISKALVVYKVYQTMFRI------------------VKESETVDSRQHCFLLQSSGHEPRYLS 389
            .....:|...|.:.:.:|::                  :::.:..|.|.:||.:.:|..:....|
  Rat   339 TLDWGRAERAYNLCEVLFKVHKFWLSDNYWLQANLYLGLQDLDCEDPRSYCFSVLASHGKSHIFS 403

  Fly   390 VETRQELLRIENSWNAAIVTSVIKLGRKTFAVSHHGKSGGLTLDWQAGFSLTEGAESATVWQYKF 454
            ||...||...|.::..|....|.:.|.||:..|..|:....|:|:..||:..:......:|::||
  Rat   404 VELGNELAVWEKAFQRATFMEVQRTGSKTYLCSWQGEMLCFTVDFALGFTCFDSKTKNVLWRFKF 468

  Fly   455 SQLRGSSDDGKSKLKLHFQDHDSRAIETKELECQVLQSLLFCMHAFLTAKVASVDPAFLSS 515
            |||:|||||||:::||.||:.|::.|||||||.|.|.::|.|:|:|:.|||||:||||:.|
  Rat   469 SQLKGSSDDGKTRVKLLFQNPDTKQIETKELEFQDLTAVLHCIHSFIAAKVASLDPAFMDS 529

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syn2	NP_788381.1	PDZ_syntrophin-like	77..159	CDD:467262	47/81 (58%)
		PH	301..407	CDD:214574	31/126 (25%)
Sntg2	NP_001401843.1	PDZ_syntrophin-like	72..154	CDD:467262	47/81 (58%)