Protein Alignment CngA and KCNH7

DIOPT Version :10

• Sequence 1: NP_001188960.1
• Gene: CngA / 36806
• FlyBaseID: FBgn0261612
• Length: 840
• Species: Drosophila melanogaster
• Sequence 2: XP_011510411.1
• Gene: KCNH7 / 90134
• HGNCID: 18863
• Length: 1204
• Species: Homo sapiens
• Alignment Length: 837
• Identity: 198/837 - (23%)
• Similarity: 344/837 - (41%)
• Gaps: 182/837 - (21%)

  Fly    84 APFAPTATITVEQAATSIPMA-VDGEVHHLHYPRRSWQRKYRQGIHRQPGGGAEQDEDEEEDDDD 147
            :|.....|..:.|.:...|:. :.|.:.| ..|:|.|.|.|               .|..:....
Human   209 SPSEADDTKALIQPSKCSPLVNISGPLDH-SSPKRQWDRLY---------------PDMLQSSSQ 257

  Fly   148 VDEDDDDEFGASVCEDNPEEAIARAD--HDTQQKQHYQPN------ASDSSYVENGRK------- 197
            :......|   |:|      :|.||.  ||.:....:..|      ||:    :|||.
Human   258 LSHSRSRE---SLC------SIRRASSVHDIEGFGVHPKNIFRDRHASE----DNGRNVKVSRSW 309

  Fly   198 LIQEPSKRSKPSALRRTLQALRQRLTKRNRPKPPDWFLEKFSNTTNTDKIGKGCPAMEDAALSSE 262
            :...|....|.|.|..|..:...:.:..|  |.|...| .||. ..|:|.....|:.:...::.:
Human   310 MAGGPFNHIKSSLLGSTSDSNLNKYSTIN--KIPQLTL-NFSE-VKTEKKNSSPPSSDKTIIAPK 370

  Fly   263 IR----------------GSSVLCNRLSVDPTLQS----HYR-----WLAIVSLAVLYNIIFVVG 302
            ::                |:.||.......|.:..    ||.     |..::.|.|:|..||...
Human   371 VKDRTHNVTEKVTQVLSLGADVLPEYKLQTPRINKFTILHYSPFKAVWDWLILLLVIYTAIFTPY 435

  Fly   303 RAVFW----------EINKSAPAFWYTLDYLCDFIYLLDTLVHMHEGFLDQG-LLVRDAFRLRRH 356
            .|.|.          |...|.... ..:|.:.|.::::|.|::....:::|. .:|.|..::..|
Human   436 SAAFLLNDREEQKRRECGYSCSPL-NVVDLIVDIMFIIDILINFRTTYVNQNEEVVSDPAKIAIH 499

  Fly   357 YFHTKGWYL-DVLSMLPTDLAYIWWPPETCSSLYLPCPVIVRLNRLLRINRLWEWFDRTETATGY 420
            ||  |||:| |:::.:|.||.......:..::|.    .:::..||||:.|:....||   .:.|
Human   500 YF--KGWFLIDMVAAIPFDLLIFGSGSDETTTLI----GLLKTARLLRLVRVARKLDR---YSEY 555

  Fly   421 PNAFRICKVVLAILVLI-HWNACMYFAI-SYEIGFSSD--SWVYNLN---GTRNN--------TL 470
            ..|  :..:::.|..|| ||.||:::|| :.|..:.:|  .|:.:|.   |.|.|        ::
Human   556 GAA--VLMLLMCIFALIAHWLACIWYAIGNVERPYLTDKIGWLDSLGQQIGKRYNDSDSSSGPSI 618

  Fly   471 QRQYIYSFYWSTLTLTTIG-ETPTPENDVEYLFVVADFLAGVLIFATIVGNIGSMISNMNVARVE 534
            :.:|:.:.|::..:||::| ...:|..:.|.:|.:...|.|.|::|:|.||:.::|..:......
Human   619 KDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTAR 683

  Fly   535 FQNRMDGVKQYMAFRRVGHELEARVIRWFAYTWSQSGALDEERVLAALPDKLKAEIAIQVHMDTL 599
            :..:|..||:::.|.::.:.|..|:..:|.:.|:.:..:|...||...|:.|:|:|.:.::...|
Human   684 YHMQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWTYTNGIDMNMVLKGFPECLQADICLHLNQTLL 748

  Fly   600 KQVRIFHDTEPGLLEALVLKLKLQVFSPGDYICRKGDVGKEMYIVKRGKLSVVGDDGITVLATLG 664
            :..:.|.....|.|.||.:|.|.....|||.:...|||...:|.:.||.:.::.||  .|:|.||
Human   749 QNCKAFRGASKGCLRALAMKFKTTHAPPGDTLVHCGDVLTALYFLSRGSIEILKDD--IVVAILG 811

  Fly   665 AGSVFGEVSVLEIAGNRTGNRRTANVRSLGYSDLFCLAKRDLWETLSDYPEARSTLTQRGCQLLR 729
            ...:|||:..|.....::    .|:||:|.|.||..:.:.||.|.|..|||
Human   812 KNDIFGEMVHLYAKPGKS----NADVRALTYCDLHKIQREDLLEVLDMYPE-------------- 858

  Fly   730 KDGLLDEQIFADSQRVHDSIEGGIEKLELSVENLNMRLARLLAEYTASQA---------KIKQRL 785
                     |:|.         .:..|||:   .|:|.....|:...||:         |:::|.
Human   859 ---------FSDH---------FLTNLELT---FNLRHESAKADLLRSQSMNDSEGDNCKLRRRK 902

  Fly   786 AKLEMNGGPGTWRLECE-----PQSRARSGRLYSLQPKRR----PRSRPDATAKSSD 833
            ...|..|       |.|     |:..|.:.|.|  |..:|    .:||..:...|.|
Human   903 LSFESEG-------EKENSTNDPEDSADTIRHY--QSSKRHFEEKKSRSSSFISSID 950

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CngA	NP_001188960.1	Ion_trans	282..529	CDD:459842	72/279 (26%)
		CAP_ED	604..717	CDD:237999	40/112 (36%)
		CLZ	720..790	CDD:465160	12/78 (15%)
KCNH7	XP_011510411.1	PAS_9	38..134	CDD:463873
		Ion_trans	417..679	CDD:459842	70/273 (26%)
		CAP_ED	753..864	CDD:237999	42/148 (28%)