Protein Alignment CngA and Cngb1

DIOPT Version :10

• Sequence 1: NP_001188960.1
• Gene: CngA / 36806
• FlyBaseID: FBgn0261612
• Length: 840
• Species: Drosophila melanogaster
• Sequence 2: NP_113997.2
• Gene: Cngb1 / 83686
• RGDID: 621809
• Length: 1338
• Species: Rattus norvegicus
• Alignment Length: 826
• Identity: 219/826 - (26%)
• Similarity: 370/826 - (44%)
• Gaps: 175/826 - (21%)

  Fly   136 EQDEDEEEDDDDVDEDDDDEFGASV--------------CEDN--------PEEAI--------- 169
            |::|::||:::..:|::.:|.|.:.              .||.        |||.|
  Rat   527 EEEEEKEEEEEKEEEEEKEEEGEATNSTVPATKEHPELQVEDTDAEAGPLIPEETIPPPERPPVS 591

  Fly   170 -ARA------------------DHDTQQKQHYQP-------------------------NASDSS 190
             |::                  |.:.::.:...|                         .||.:|
  Rat   592 PAKSDTLAVPGAATHRKKLPSQDDEAEELKALSPAESPVVAWSDPTTPQEADGEDRAASTASQNS 656

  Fly   191 YVENGRKLIQEPSKRSKPSALRRTLQALRQRL------TKRNRPKPPDWFLEKFSNTTNTDKIGK 249
            .:.|.|  :||..|..|    .|| :.::::|      :....|||           :...|...
  Rat   657 AIINDR--LQELVKMFK----ERT-EKVKEKLIDPDVTSDEESPKP-----------SPAKKAPD 703

  Fly   250 GCPAME--DAALSSEIRGSSVLCNRL------------SVDPTLQSHY-RWLAIVSLAVLYNIIF 299
            ..||.:  :|..:.|.....:||.:.            |:||.....| .||..|.||..:|...
  Rat   704 SAPAQKPAEAEAAEEEHYCDMLCCKFKRRPWKMYQFPQSIDPLTNLMYILWLFFVVLAWNWNCWL 768

  Fly   300 VVGRAVFWEINKSAPAFWYTLDYLCDFIYLLD-TLVHMHEGFLDQGLLVRDAFRLRRHYFHTKGW 363
            :..|..|..........|..:||||||||||| |:..|...|:..|.::.|...:|.:|..::.:
  Rat   769 IPVRWAFPYQRADNIHLWLLMDYLCDFIYLLDITVFQMRLQFVKGGDIITDKKEMRNNYLKSQRF 833

  Fly   364 YLDVLSMLPTDLAYIWWPPETCSSLYLPCPVIVRLNRLLRINRLWEWFDRTETATGYPNAFRICK 428
            .:|:|.:||.|..|          |.|....::||.|.|:....:|:.:|.|........:|:.:
  Rat   834 KMDLLCLLPLDFLY----------LKLGVNPLLRLPRCLKYMAFFEFNNRLEAILSKAYVYRVIR 888

  Fly   429 VVLAILVLIHWNACMYFAISYEIGFSSDSWVYNLNGTRNNTLQRQYIYSFYWSTLTLTTIGETPT 493
            ....:|..:|.|:|:|:..|...|..|..|||  :|..|:     ||..:||:..||.|||..|.
  Rat   889 TTAYLLYSLHLNSCLYYWASAFQGIGSTHWVY--DGVGNS-----YIRCYYWAVKTLITIGGLPD 946

  Fly   494 PENDVEYLFVVADFLAGVLIFATIVGNIGSMISNMNVARVEFQNRMDGVKQYMAFRRVGHELEAR 558
            |:...|.:|.:.::..||..|:.::|.:..::......:..:::.||...:||.|.::...::.|
  Rat   947 PQTLFEIVFQLLNYFTGVFAFSVMIGQMRDVVGAATAGQTYYRSCMDSTVKYMNFYKIPRSVQNR 1011

  Fly   559 VIRWFAYTWSQSGALDEERVLAALPDKLKAEIAIQVHMDTLKQVRIFHDTEPGLLEALVLKLKLQ 623
            |..|:.|||...|.|||..::..||||::.::||.|:.:.:.:|.:|...:..::..::.:|:..
  Rat  1012 VKTWYEYTWHSQGMLDESELMVQLPDKMRLDLAIDVNYNIVSKVALFQGCDRQMIFDMLKRLRSV 1076

  Fly   624 VFSPGDYICRKGDVGKEMYIVKRGKLSVV-GDDGITVLATLGAGSVFGEVSVLEIAGNRTGNRRT 687
            |:.|.||:|:||::|:||||::.|::.|: |.||..||.||.|||||||:|:|.:.|   |||||
  Rat  1077 VYLPNDYVCKKGEIGREMYIIQAGQVQVLGGPDGKAVLVTLKAGSVFGEISLLAVGG---GNRRT 1138

  Fly   688 ANVRSLGYSDLFCLAKRDLWETLSDYPEARSTLTQRGCQLLRKDG-------------------L 733
            |||.:.|:::||.|.|:||.|.|..|||::..|.::..::||.:.                   |
  Rat  1139 ANVVAHGFTNLFILDKKDLNEILVHYPESQKLLRKKARRMLRNNNKPKEEKSVLILPPRAGTPKL 1203

  Fly   734 LDEQIFADSQRVHDSIEGGIEKLELSVENLNMRLARLLAEYTAS--QAKIKQRLAKLEMNGGPGT 796
            .:..:.|..:......:||      .:.:|..||..|.|...|:  |..::|..:..|..|..|:
  Rat  1204 FNAALAAAGKMGPRGAKGG------KLAHLRARLKELAALEAAARQQQLLEQAKSSQEAGGEEGS 1262

  Fly   797 WRLECEPQSRARSGRLYSLQPKR-----RPRSRPDATAKSSDAAKQ 837
            ...: :|..:..|      :||.     .|.|.|.|:||...:.::
  Rat  1263 GATD-QPAPQEPS------EPKEPPEPPAPSSPPPASAKPEGSTEE 1301

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CngA	NP_001188960.1	Ion_trans	282..529	CDD:459842	74/248 (30%)
		CAP_ED	604..717	CDD:237999	53/113 (47%)
		CLZ	720..790	CDD:465160	15/90 (17%)
Cngb1	NP_113997.2	PLN03192	743..>1129	CDD:215625	130/402 (32%)
		CAP_ED	1057..1166	CDD:237999	51/111 (46%)