Protein Alignment CngA and kcnh4b

DIOPT Version :10

• Sequence 1: NP_001188960.1
• Gene: CngA / 36806
• FlyBaseID: FBgn0261612
• Length: 840
• Species: Drosophila melanogaster
• Sequence 2: XP_073774395.1
• Gene: kcnh4b / 567442
• ZFINID: ZDB-GENE-121214-54
• Length: 1193
• Species: Danio rerio
• Alignment Length: 720
• Identity: 178/720 - (24%)
• Similarity: 313/720 - (43%)
• Gaps: 137/720 - (19%)

  Fly   175 DTQQKQHYQPNASDSSYVENGRKLIQEPSKRSKPSALRRTLQALRQRLTKRNRPKPPDWFLEKFS 239
            :|.:|.|:.....|.:   |.|     .:::|..|..||...|:..:||            .:|:
Zfish   135 ETHEKSHHSSKTDDKA---NSR-----TTEKSHISKARRRGHAMIYQLT------------SQFT 179

  Fly   240 NTTNTD-KIGKGC---PAMEDAALSSEIRGSSVLCNRLSVDPTLQSHYRWLAI-----VSLAVLY 295
            ..:..| |:.:..   |::.:..::: ::.|..:....||...|   :.|:.:     |::.|.|
Zfish   180 RDSKNDVKLSRDMFEKPSLPEYKVAA-VQKSRFILLHYSVSKAL---WDWMILLATFYVAVTVPY 240

  Fly   296 NIIFVVGRAVFWEINKSAPAFWYTLDYLCDFIYLLDTLVHMHEGFLDQ-GLLVRDAFRLRRHYFH 359
            |:.|.....|     ::|.......|...:.:::||.:::....::.| |.:|.:...:..||..
Zfish   241 NVCFTAYSDV-----ETAGRSTIVSDIAVEMLFILDIILNFRTTYVSQSGQVVYEPRSICLHYAT 300

  Fly   360 TKGW-YLDVLSMLPTDLAYIWWPPETCSSLYLPCPVIVRLNRLLRINRLWEWFDRTETATGYPNA 423
            |  | ::|:::.||.||.|.:  ..|.:||.    .:::..||||:.||.:..||..
Zfish   301 T--WFFVDLVAALPFDLLYAF--NITVTSLV----HLLKTVRLLRLLRLLQKLDRYS-------- 349

  Fly   424 FRICKVVLAIL-----VLIHWNACMYFAI-----------SYEIGFSSDSWVYNLNGTR------ 466
             :...:||.:|     :|.||.||:::.|           :::||     |::.| |.|
Zfish   350 -QYSAMVLTLLMSMFALLAHWMACIWYIIGRKEMETNASGAWDIG-----WLHEL-GKRLDKPYM 407

  Fly   467 NNT-----LQRQYIYSFYWSTLTLTTIGETPTPEN-DVEYLFVVADFLAGVLIFATIVGNIGSMI 525
            |:|     ::..||.|.|::..:||::|......| |.|.:|.|...|.|.|:.|.:.||:.::|
Zfish   408 NSTFGGPSVRSAYIASLYFTLSSLTSVGFGNVCANTDAEKIFSVCTMLIGALMHAVVFGNVTAII 472

  Fly   526 SNMNVARVEFQNRMDGVKQYMAFRRVGHELEARVIRWFAYTWSQSGALDEERVLAALPDKLKAEI 590
            ..|...|..:..||..:|.::...|:..:|:.|::.:|..|||.:..:|...:|...||:|:|:|
Zfish   473 QRMYSRRSLYHTRMKDLKDFIRVHRLPQQLKQRMLEYFQTTWSVNNGIDVNELLHDFPDELRADI 537

  Fly   591 AIQVHMDTLKQVRIFHDTEPGLLEALVLKLKLQVFSPGDYICRKGDVGKEMYIVKRGKLSVVGDD 655
            |:.::.|.| |:.:|.....|.|.:|.|.:|....:||:|:.|:||..:..|.|..|.|.|:.|:
Zfish   538 AMHLNKDIL-QLPVFEAASRGCLRSLSLHIKTSFCTPGEYLIRQGDALQANYFVCSGSLEVLKDN 601

  Fly   656 GITVLATLGAGSVFGEVSVLEIAGNRTGNRRTANVRSLGYSDLFCLAKRDLWETLSDYPEARSTL 720
              .|||.||.|.:.|.    ::.|.....:..|:|::|.|.||..:..:.|.:.|..|||..:..
Zfish   602 --MVLAILGRGDLIGS----DLPGQNHVIKTNADVKALTYCDLQYIGVKGLSDVLELYPEYANIF 660

  Fly   721 T---QRGCQLLRKDGLLDEQIFADSQRVHDSIEGGIEKLELSVENLNMRLARLLAE----YTASQ 778
            |   .|......::|...||.:.|              ..:|.||....:.....:    :..|.
Zfish   661 TIDIHRNLTYNLREGSETEQNYPD--------------FSVSTENKRPSVVEKADDPDKYFHVSS 711

  Fly   779 AKIKQRLAKLEMNGGP----------GTWRLECEPQSRARSG-RLYSLQPKRRPRSR-------P 825
            |....|...|...|.|          |...::.......||. |.:|..|..:|.|:       |
Zfish   712 ASSTCRNLLLPNLGSPVRRTSLGNLLGEELMQFNALRHCRSPVRGWSPNPSPKPPSKVQKQTQQP 776

  Fly   826 DATAK 830
            .:|.|
Zfish   777 SSTPK 781

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CngA	NP_001188960.1	Ion_trans	282..529	CDD:459842	71/281 (25%)
		CAP_ED	604..717	CDD:237999	37/112 (33%)
		CLZ	720..790	CDD:465160	13/76 (17%)
kcnh4b	XP_073774395.1	None