Protein Alignment CngA and kcnh2a

DIOPT Version :10

• Sequence 1: NP_001188960.1
• Gene: CngA / 36806
• FlyBaseID: FBgn0261612
• Length: 840
• Species: Drosophila melanogaster
• Sequence 2: XP_073775577.1
• Gene: kcnh2a / 563802
• ZFINID: ZDB-GENE-070912-699
• Length: 1254
• Species: Danio rerio
• Alignment Length: 838
• Identity: 182/838 - (21%)
• Similarity: 331/838 - (39%)
• Gaps: 185/838 - (22%)

  Fly    12 DRVNTMMSNRRRPETESP--KYGYNLSNRPMYRTTRLVGPASSAPAQLQLPCGSHQATLGVAP-P 73
            |:..|...:..||...||  ..|::.|:..::..|....|:|.:.|..:    |.::..|:.| |
Zfish   225 DKAQTESESELRPSEVSPPLPQGFSQSSPRLHNLTSEASPSSCSMAHSR----SCESLCGMRPSP 285

  Fly    74 PLEEISGGLFAPFAPTATITVEQAATSIPMAVDGEVHHLHYPRRSWQRKYRQGIHRQPGGGAEQD 138
            ...:.:.....|..|::|..:.:.|:......|.::..|                |..|.|.
Zfish   286 STNDFNWDRKLPVRPSSTGAMHRKASLQNATSDSDLIRL----------------RSSGRGT--- 331

  Fly   139 EDEEEDDDDVDEDDDDEFGASVCEDNPEEAIARADHDTQQKQHYQPNASDSSYVENGRKLIQEPS 203
                            :...::.:..|:..||                     |..|...|..|.
Zfish   332 ----------------QISHNLIDMKPDALIA---------------------VPTGEIDIIAPC 359

  Fly   204 KRSKPSALRRTLQALRQRLTKRNRPKPPDWFLEKFSNTTN--TDKIGKGCPAMEDAALSS-EIRG 265
            |                             .:::..|.|.  |..:..|...:.:..|.: .|..
Zfish   360 K-----------------------------LIDRTHNVTEKVTQVLSLGADVLPEYKLQAPRIHK 395

  Fly   266 SSVLCNRLSVDPTLQSHYR-----WLAIVSLAVLYNIIFVVGRAVFW------EINKSAPAFWYT 319
            .::|            ||.     |..::.|.|:|..||....|.|.      |:.:.......|
Zfish   396 WTIL------------HYSPFKAVWDWVILLLVIYTAIFTPYSAAFLLSDEEEEVIQRCGYSCST 448

  Fly   320 L---DYLCDFIYLLDTLVHMHEGFLDQG-LLVRDAFRLRRHYFHTKGWYL-DVLSMLPTDLAYIW 379
            |   |.:.|.::::|.:::....:::.. .:|....|:..|||  |||:| |:::.:|.||....
Zfish   449 LNVVDLIVDIMFVVDIVINFRTTYVNSNDEVVSQPGRIAVHYF--KGWFLIDMVAAIPFDLLIYR 511

  Fly   380 WPPETCSSLYLPCPVIVRLNRLLRINRLWEWFDRTETATGYPNAFRICKVVLAILVLIHWNACMY 444
            ...||.:|..|  ..:::..||||:.|:....||............:|...|    :.||.||::
Zfish   512 SEEETTTSTTL--IGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFAL----IAHWLACIW 570

  Fly   445 FAIS--YEIGFSSDSWVYNL---------NGTRNN--TLQRQYIYSFYWSTLTLTTIG-ETPTPE 495
            :||.  ...|.|...|:.:|         :..|.:  :::.:|:.:.|::..:||::| ...:|.
Zfish   571 YAIGNVERSGPSRIGWLNSLGDQLGKPYNSSVRGSGPSIKDKYVTALYFTFSSLTSVGFGNVSPN 635

  Fly   496 NDVEYLFVVADFLAGVLIFATIVGNIGSMISNMNVARVEFQNRMDGVKQYMAFRRVGHELEARVI 560
            .:.|.:|.:...|.|.|::|:|.||:.::|..:......:..:|..|::::.|.::.:.|..|:.
Zfish   636 TNSEKIFSICVMLIGALMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLE 700

  Fly   561 RWFAYTWSQSGALDEERVLAALPDKLKAEIAIQVHMDTLKQVRIFHDTEPGLLEALVLKLKLQVF 625
            .:|.:.||.:..:|...||...|:.|:|:|.:.::...|:..:.|..:..|.|.||.:|.|....
Zfish   701 EYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRTLLQSCKAFKGSSKGCLRALAMKFKTTHA 765

  Fly   626 SPGDYICRKGDVGKEMYIVKRGKLSVVGDDGITVLATLGAGSVFGEVSVLEIAGNRTGNRRTANV 690
            .|||.:...|||...:|.:.||.:.::..|  .|:|.||...:|||    .|.......:.:|:|
Zfish   766 PPGDTLVHAGDVISALYFISRGSIEILKGD--VVVAILGKNDIFGE----PINSYARPGKSSADV 824

  Fly   691 RSLGYSDLFCLAKRDLWETLSDYPE--------------ARSTLTQRGCQLLRKD----GLLDE- 736
            |:|.|.||..:.:.|:.|.|..|||              .|.|.|:.|......|    |.||.
Zfish   825 RALTYCDLHKIHRDDVLEVLEMYPEFSDYFWSNLEITFNLRDTNTKAGSMSSDPDDSDNGGLDHH 889

  Fly   737 ----QIF----------ADSQRVHDSIEGGIEKLELS-VENLNMRLARLLAEYTASQA 779
                ::|          ||::|..|.:.....:.:.| .::.|.:.|...::..|||:
Zfish   890 TRRAKLFFQSKRNSISRADTERTEDRLNRMTFRTQTSGKQHENRQTAHRSSDIFASQS 947

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CngA	NP_001188960.1	Ion_trans	282..529	CDD:459842	69/276 (25%)
		CAP_ED	604..717	CDD:237999	38/126 (30%)
		CLZ	720..790	CDD:465160	17/80 (21%)
kcnh2a	XP_073775577.1	None