Protein Alignment CngA and kcnh1a

DIOPT Version :10

• Sequence 1: NP_001188960.1
• Gene: CngA / 36806
• FlyBaseID: FBgn0261612
• Length: 840
• Species: Drosophila melanogaster
• Sequence 2: XP_073783443.1
• Gene: kcnh1a / 560568
• ZFINID: ZDB-GENE-061226-1
• Length: 979
• Species: Danio rerio
• Alignment Length: 647
• Identity: 166/647 - (25%)
• Similarity: 273/647 - (42%)
• Gaps: 126/647 - (19%)

  Fly   173 DHDTQQK-----QHYQPNASDSSYVENGR-------KLIQEPSKRSKPSALRRTLQALRQRLTKR 225
            |.||.:|     ::|:.|:.:....:..|       |:....:::.|......|.    ..:|..
Zfish    85 DKDTSEKVRLTFENYEMNSFEILMYKKNRTPVWFFVKIAPIRNEQEKVVLFLCTF----SDITAF 145

  Fly   226 NRPKPPD----WFLEKFSNTTNT------------DKIGKGCPAMEDAALSSEIR-GSSVLCNRL 273
            .:|...|    |  .||:..|..            ..:.||....:.:.|:..:: ||.:|....
Zfish   146 KQPIEDDSSKGW--GKFARLTRALTSSRGVLQQLQPTVHKGENVHKHSRLAEVLQLGSDILPQYK 208

  Fly   274 SVDPTLQSH-----------YRWLAIV-----SLAVLYNIIFVVGRAVFWEINKSAPAFWYTLDY 322
            ...|....|           :.|:.::     ::.|.||:.|.         .|.....|..:|.
Zfish   209 QETPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVSFK---------TKQNNVTWLVVDS 264

  Fly   323 LCDFIYLLDTLVHMHEGFL-DQGLLVRDAFRLRRHYFHTKGWY-LDVLSMLPTDLAYIW------ 379
            :.|.|:|:|.:::.|..|: ..|.::.|...:|.:|..|  |: :|:||.||.|:...:
Zfish   265 IVDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMNYLKT--WFVIDLLSCLPYDVINAFENVDEN 327

  Fly   380 W----PPETCSSLYLPCPVIVRLNRLLRINRLWEWFDRTETATGYPNAFRICKVVLAILVLI--- 437
            |    ..:..|||:....|:    ||||:.|:....|         :.......||.:||.:
Zfish   328 WNHRAVTQGISSLFSSLKVV----RLLRLGRVARKLD---------HYIEYGAAVLVLLVCVFGL 379

  Fly   438 --HWNACMYFAI-SYEI------GFSSDSWVY------------NLNGT----RNNTLQRQYIYS 477
              ||.||::::| .||:      ...:|||:|            |.:||    ...|....||.|
Zfish   380 AAHWLACIWYSIGDYEVIDEDRNTVRTDSWLYMLAESIGTPYRFNASGTGRWEGGPTKDTVYITS 444

  Fly   478 FYWSTLTLTTIG-ETPTPENDVEYLFVVADFLAGVLIFATIVGNIGSMISNMNVARVEFQNRMDG 541
            .|::..:||:|| ....|..|.|.:|.||..:.|.|::|||.||:.::...|......:...::.
Zfish   445 LYFTMTSLTSIGFGNIAPTTDGEKIFAVAMMMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLNS 509

  Fly   542 VKQYMAFRRVGHELEARVIRWFAYTWSQSGALDEERVLAALPDKLKAEIAIQVHMDTLKQVRIFH 606
            |:.::...:|...|..||:.:.|.|||.|..:|.|:||...|..::|:|.:.::....|:...|.
Zfish   510 VRDFLKLYQVPKGLSERVMDYIASTWSMSHGIDTEKVLQICPKDMRADICVHLNRKVFKEHPAFR 574

  Fly   607 DTEPGLLEALVLKLKLQVFSPGDYICRKGDVGKEMYIVKRGKLSVVGDDGITVLATLGAGSVFGE 671
            ....|.|.||.::.:....:|||.|...|:....:..|..|.|.|:.||  .|:|.||.|.|||:
Zfish   575 LASDGCLRALAMEFQTIHCAPGDLIYHAGESVDSLCFVVSGSLEVIQDD--EVVAILGKGDVFGD 637

  Fly   672 VSVLEIAGNRTGNRRTANVRSLGYSDLFCLAKRDLWETLSDYPEARSTLTQRGCQL---LRK 730
            |...|:    |..:..||||:|.|.||..: |||..:.:.::..|.|....|...|   |||
Zfish   638 VFWKEV----TLAQACANVRALTYCDLHVI-KRDALQKVLEFYTAFSNHFSRNLLLTYNLRK 694

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CngA	NP_001188960.1	Ion_trans	282..529	CDD:459842	78/303 (26%)
		CAP_ED	604..717	CDD:237999	38/112 (34%)
		CLZ	720..790	CDD:465160	5/14 (36%)
kcnh1a	XP_073783443.1	None